Capacitive sensor array for localization of bioparticles in CMOS lab-on-a-chip

Romani, Annalisa; Manaresi, Nicolò; Marzocchi, L.; Medoro, Gianni; Leonardi, A.; Altomare, Luigi; Tartagni, Marco; Guerrieri, R.

doi:10.1109/isscc.2004.1332675

Cited by 67 publications

(41 citation statements)

References 4 publications

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“…The contact of cells with the passivation layers on top of single electrodes as well as created dipole moment are significantly detected by a capacitance change (e.g., 1 fF capacitance variation on 400 lm 2 electrode [19]). In another effort, a cell detection method has been reported for cell localization using an array of parallel electrodes-one common electrode covering the microfluidic structure, and an array of addressable electrodes on top of CMOS chip [8].…”

Section: Cellular Activity Monitoringmentioning

confidence: 99%

“…As already mentioned, for a biological or chemical detection, a different interface circuit should be designed and implemented. Such an interface circuit often features an array of capacitive sensors with addressable sensing electrodes to detect sub femto Farad capacitance changes DC (e.g., DC = 0.2 fF [8]) corresponding to each sensing site. For this, a low complexity and small area interface circuit are required for high spatial resolution sensor arrays.…”

Section: Capacitive Readout Circuits For Locsmentioning

confidence: 99%

“…For this, a capacitive sensor for LoC applications can be implemented through a simple architecture. This simplicity is an important issue for the design and implementation of a large capacitive sensor array [8] which is not the case of a MBCS application with only one single sensing capacitor.…”

Section: Introductionmentioning

confidence: 99%

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CMOS based capacitive sensor laboratory-on-chip: a multidisciplinary approach

Ghafar-Zadeh¹,

Sawan²,

Therriault

2008

Analog Integr Circ Sig Process

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In this paper, we review the recent advances of CMOS-based capacitive sensors for Lab-on-chip (LoC) applications. LoC design is a multidisciplinary approach of adapting classical biochemical assays to a miniaturized platform by exploiting advances in microelectronic and microfluidic technologies. By offering low cost and integrated devices, CMOS based LoCs could be amenable to a large number of biological and biochemical assays for disease diagnostics and biotechnology in the near future. While an exhaustive, all-encompassing review of CMOSbased LoCs is beyond the scope of this review, we have focused on the design and implementation of CMOS-based capacitive sensor LoCs for the most important biochemical applications. For each application, the corresponding biochemical sensing layer, interface circuit and microfluidic packaging technique are discussed based on the recent literature studies.

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Section: Cellular Activity Monitoringmentioning

confidence: 99%

Section: Capacitive Readout Circuits For Locsmentioning

confidence: 99%

See 1 more Smart Citation

CMOS based capacitive sensor laboratory-on-chip: a multidisciplinary approach

Ghafar-Zadeh¹,

Sawan²,

Therriault

2008

Analog Integr Circ Sig Process

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“…Romani et al developed a CMOS Lab-on-a-chip incorporating a capacitance sensor array and dielectrophoretic cages for localization of bioparticles, wherein the sensors detect variations in the dielectric permittivity due to the presence of bioparticles in between the on-chip electrodes and an external conducting lid [2].…”

Section: Introductionmentioning

confidence: 99%

A CMOS Capacitance Sensor for Cell Adhesion Characterization

Prakash

Abshire

Urdaneta³

et al.

2005 IEEE International Symposium on Circuits and Systems

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Abstract-We describe a CMOS capacitance sensor for measuring the capacitive coupling between living cells and the underlying substrate, a quantity that can be used to characterize cell adhesion strength and cell health. The capacitance sensor operates on the charge sharing principle, mapping sensed capacitance values to voltages. The sensor has been fabricated in a commercially available 0.5 µm, 2-poly 3-metal CMOS technology. Experimental results are presented for bench tests using a micropositioned electrode and in vitro tests with cells cultured directly on the chip surface. The sensor achieves an empirical distance resolution of 3 nm and capacitance resolution of 135 aF. The sensors have been successfully used for long term monitoring of cell viability in vitro.

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“…Many optical assays are being migrated to LoC systems since optical sensors technology has proven itself as reliable in the microelectronic technology. This can serve the large number of optical assays being carried out on biomedical labs [4][5][6][7].…”

mentioning

confidence: 99%

Towards Bio-impedance Based Labs: A Review

Pérez¹,

Maldonado²,

Yufera³

et al. 2016

JEE

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Abstract:In this article, some of the main contributions to BI (Bio-Impedance) parameter-based systems for medical, biological and industrial fields, oriented to develop micro laboratory systems are summarized. These small systems are enabled by the development of new measurement techniques and systems (labs), based on the impedance as biomarker. The electrical properties of the life mater allow the straightforward, low cost and usually non-invasive measurement methods to define its status or value, with the possibility to know its time evolution. This work proposes a review of bio-impedance based methods being employed to develop new LoC (Lab-on-a-Chips) systems, and some open problems identified as main research challenges, such as, the accuracy limits of measurements techniques, the role of the microelectrode-biological impedance modeling in measurements and system portability specifications demanded for many applications.

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Capacitive sensor array for localization of bioparticles in CMOS lab-on-a-chip

Cited by 67 publications

References 4 publications

CMOS based capacitive sensor laboratory-on-chip: a multidisciplinary approach

CMOS based capacitive sensor laboratory-on-chip: a multidisciplinary approach

A CMOS Capacitance Sensor for Cell Adhesion Characterization

Towards Bio-impedance Based Labs: A Review

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