CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Lee, Eun Soo; Uhm, Kyung Ok; Lee, Yun Mi; Han, Myoung Sook; Lee, Myung Sik; Park, Ji‐Man; Suh, Pann Ghill; Park, Sun Hwa; Kim, Hyeon Soo

doi:10.1016/j.bbrc.2007.07.068

Cited by 70 publications

(52 citation statements)

References 17 publications

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“…Indeed, we have previously demonstrated that NCRAE has the ability in vitro to enhance glucose uptake in L6 muscle cell line and does not act on hepatic glucagon-induced glycogenolysis via hepatic glucose 6 phosphatase activity (Azay-Milhau et al, 2013). The results on L6 muscular cells are in agreement with the report of Lee et al (2007) on the same in vitro model. Here, we have shown that SCCAM possess a similar capacity that NCRAE to enhance the glucose uptake on the L6 cells, indicating the value of the mixture of chicoric acid and chlorogenic acid on insulin sensitivity.…”

Section: Discussionsupporting

confidence: 89%

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Ferrare

Bidel

Awwad

et al. 2018

Journal of Ethnopharmacology

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Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect, Journal of Ethnopharmacology, https://doi.org/10. 1016/j.jep.2017.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACT Ethnopharmacological relevance Chicory (Cichorium intybus L.) is an indigenous vegetable widely cultivated in Europe,America and Asia. In ancient times, the leaves, flowers, seeds, and roots have been used as a wealth of health benefits including its tonic effects, the ability to ease digestive problems and to detoxify liver. In Indian traditional therapy, chicory was known to possess antidiabetic effect. In the traditional medicine of Bulgaria and Italy, chicory was used as hypoglycemic decoctions. Aims of the studiesWe wanted to obtain the complete chemical composition of the natural chicoric acid extract (NCRAE), a chicory root extract rich in chicoric acid, which previously showed its glucose tolerance effect in normal rats. To investigate if the whole NCRAE is required to be effective, we performed a comparative in vivo experiment on STZ diabetic rats treated either with NCRAE or a mixture composed of the two major compounds of NCRAE. Materials and Methods1 K. Ferrare and L.P.R. Bidel contributed equally to this study. ResultsThe LC-MS analysis confirmed the high abundance of chicoric acid (64.2%) in NCRAE and a second part of NCRAE is composed of caffeoylquinic acids (CQAs) at 19.6% with among them the chlorogenic acid. This result has permitted us to prepare a mixture of synthetic Lchicoric acid (70%) and synthetic chlorogenic acid (30%): the solution is designated SCCAM.Our results showed that both NCRAE and SCCAM are able to improve a glucose tolerance in STZ diabetic rats after a subchronic administration of seven days. Alone NCRAE allows to significantly decrease the basal hyperglycemia after six days of treatment. In vivo experiments on streptozotocin Chicoric acid 72.4 % Caffeoyl-quinic acids 19.6 % NCRAE contained a mixture of CRA, CGA and others caffeoyl derivatives that confer this antidiabetic -NCRAE induced a antidiabetic effect, -SCCAM induced an glucose

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Section: Discussionsupporting

confidence: 89%

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Ferrare

Bidel

Awwad

et al. 2018

Journal of Ethnopharmacology

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“…Although the role of AMPK in cardiovascular disorders, including obesity and diabetes, is well understood, its role in inflammatory and demyelinating disease including EAE is yet to be established. Several pharma- cological compounds, including 5-aminoimidazole-4-carboxamide ribonucleotide (14), resveratrol (34), caffeic acid phenethyl ester (35), lipoic acid (36), curcumin (37), and metformin (12), activate AMPK and also attenuate EAE disease progression (11,(38)(39)(40)(41). These pharmacological agents may modulate immune response through both AMPK-dependent and -independent pathways.…”

Section: Discussionmentioning

confidence: 99%

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis

Mangalam

Rattan

Salehiniya

et al. 2016

The Journal of Immunology

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The AMP-activated protein kinase, AMPK, is an energy-sensing, metabolic switch implicated in various metabolic disorders; however, its role in inflammation is not well defined. We have previously shown that loss of AMPK exacerbates experimental autoimmune encephalomyelitis (EAE) disease severity. In this study, we investigated the mechanism through which AMPK modulates inflammatory disease like EAE. AMPKα1 knockout (α1KO) mice with EAE showed severe demyelination and inflammation in the brain and spinal cord compared with wild-type due to higher expression of proinflammatory Th17 cytokines, including IL-17, IL-23, and IL-1β, impaired blood–brain barrier integrity, and increased infiltration of inflammatory cells in the CNS. Infiltrated CD4 cells in the brains and spinal cords of α1KO with EAE were significantly higher compared with wild-type EAE and were characterized as IL-17 (IL-17 and GM-CSF double-positive) CD4 cells. Increased inflammatory response in α1KO mice was due to polarization of macrophages (Mϕ) to proinflammatory M1 type phenotype (IL-10lowIL-23/IL-1β/IL-6high), and these M1 Mϕ showed stronger capacity to induce allogenic as well as Ag-specific (myelin oligodendrocyte glycoprotein [MOG]35–55) T cell response. Mϕ from α1KO mice also enhanced the encephalitogenic property of MOG35–55–primed CD4 T cells in B6 mice. The increased encephalitogenic MOG-restricted CD4+ T cells were due to an autocrine effect of IL-1β/IL-23–mediated induction of IL-6 production in α1KO Mϕ, which in turn induce IL-17 and GM-CSF production in CD4 cells. Collectively, our data indicate that AMPK controls the inflammatory disease by regulating the M1 phenotype–Th17 axis in an animal model of multiple sclerosis.

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“…Cabe destacar la importancia de realizar una identificación y cuantificación de los componentes del propóleos ya que la actividad biológica de los polifenoles varía dependiendo de su configuración estructural, como lo plantean Zang et al (2006) al demostrar diferencias en la actividad biológi-ca de distintos compuestos polifenólicos sobre un mismo blanco. Recientemente Lee et al (2007) han descrito que el ácido cafeico fenil éster (CAPE) tiene la capacidad de inducir la captación de glucosa en cultivos celulares de músculo estriado, mediante la vía de AMPK; este hecho tiene especial relevancia, ya que CAPE es el segundo compuesto en abundancia identificado en la muestra de propóleos en estudio.…”

Section: Discussionunclassified

Efecto del Propóleos Chileno sobre el Metabolismo de Glucosa en Ratones Diabéticos

Pacheco

Daleprane²,

Freitas³

et al. 2011

Int. J. Morphol.

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RESUMEN:En el presente estudio se evaluó el efecto del propóleos sobre el metabolismo de la glucosa en ratones C57/BL-6 con diabetes mellitus tipo 2 inducida por dieta alta en grasa. Se midieron los cambios en las concentraciones séricas de lípidos, glucosa e insulina, y el efecto sobre la captación de 2-deoxi-[2,6- 14 C]-D-glucosa inducida por insulina en músculo sóleo de ratones tratados con propóleos fue significativamente superior al grupo control (P<0.05). En resumen, nuestros datos confirman que el propóleos es capaz de modular el metabolismo de glucosa en ratones C57/BL-6 con diabetes mellitus tipo 2 inducida por dieta alta en grasa. Los datos obtenidos constituyen un importante antecedente que avala el posible uso del propóleos como fuente de polifenoles con actividad antidiabetogénica.

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CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Cited by 70 publications

References 17 publications

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage–Th17 Axis

Efecto del Propóleos Chileno sobre el Metabolismo de Glucosa en Ratones Diabéticos

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