Capecitabine-loaded bacterial membrane vesicles derived from Enterococcus faecalis promotes apoptosis in HT-29 colon cancer cells

Erdoğan, Kübra; Isik, Melis; Barut, Dilan; Sengel-Türk, Ceyda Tuba; Amasya, Gülin; Derkuş, Burak; Çabuk, Ahmet; Çelik, Pınar Aytar

doi:10.1016/j.bej.2022.108722

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Another study demonstrated that daily intranasal administration of curcumin-loaded EVs reduced the severity of experimental autoimmune encephalomyelitis, potentially by promoting apoptosis in microglial cells [132]. Enterococcus faecalis Capacitabine Anti-cancer therapy [151] Pseudomonas aeruginosa Gentamicin Cepacia syndrome treatment [152] Acinetobacter baumannii Levofloxacin Intestinal bacterial infection treatment [153] E. coli Paclitaxel Anti-cancer therapy [154] Emerging evidence indicates the potential of EVs and their contents as biomarkers for monitoring the response to antidepressant treatment in individuals with MDD. Those findings include significant changes in EVs and their contents, before and after antidepressant treatment in patients with MDD, including mitochondrial-related proteins, BDNF/pro-BDNF levels, and certain miRNAs.…”

Section: Evs and Antidepressant Treatmentmentioning

confidence: 99%

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

Louka,

Koumandou

2024

CIMB

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In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human health nd disease and set the underpinnings for the development of novel chemical compounds and pharmaceuticals. In this review, we examine the link between bacteria-derived exosomes in the gastrointestinal tract and mental disorders, such as depression and anxiety disorders. Crucially, we focus on whether changes in the gut environment affect the human mental state or the other way around. Furthermore, the possibility of handling bacteria-derived exosomes as vectors of chemicals to treat such conditions is examined.

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Section: Evs and Antidepressant Treatmentmentioning

confidence: 99%

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

Louka,

Koumandou

2024

CIMB

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“…OMVs were collected from the supernatant of the bacterial culture as described in ref. 2. The cultures (1000 mL each) grown for 24 hours at 37 1C were centrifuged at 10 000 Â g for 15 minutes at 4 1C to collect bacterial cells.…”

Section: Omv Isolationmentioning

confidence: 99%

“…By studying the structure of protein channels, we have gained a more detailed understanding of how porins, specific channels, TonB-linked receptors, and other proteins function. 1,2 It is now known that cells can form blebs with the outer membrane as coating and release them into the environment. Those produced by Gram-negative bacteria are known as outer membrane vesicles (OMVs).…”

Section: Introductionmentioning

confidence: 99%

“…Three mechanisms have been proposed to explain the process: (1) vesiculation may be caused by loss of interaction between the outer membrane caused by different speeds and the underlying peptidoglycan layer, and thus vesicles may be released. (2) Vesicles can be released with turgor pressure of the outer membrane caused by the accumulation of periplasmic proteins or peptidoglycan parts in the periplasmic cavity. (3) As seen in studies with Pseudomonas aeruginosa, the accumulation of negative charges of the quinolone (PQS) signal of the outer membrane in lipopolysaccharides and therefore the formation of external membrane curvature can lead to the release of vesicles.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between bacterial outer membrane vesicles and halophilic adaptation

et al. 2023

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Bacterial Membrane Vesicles as Smart Drug Delivery and Carrier Systems: A New Nanosystems Tool for Current Anticancer and Antimicrobial Therapy

et al. 2023

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Bacterial membrane vesicles (BMVs) are known to be critical communication tools in several pathophysiological processes between bacteria and host cells. Given this situation, BMVs for transporting and delivering exogenous therapeutic cargoes have been inspiring as promising platforms for developing smart drug delivery systems (SDDSs). In the first section of this review paper, starting with an introduction to pharmaceutical technology and nanotechnology, we delve into the design and classification of SDDSs. We discuss the characteristics of BMVs including their size, shape, charge, effective production and purification techniques, and the different methods used for cargo loading and drug encapsulation. We also shed light on the drug release mechanism, the design of BMVs as smart carriers, and recent remarkable findings on the potential of BMVs for anticancer and antimicrobial therapy. Furthermore, this review covers the safety of BMVs and the challenges that need to be overcome for clinical use. Finally, we discuss the recent advancements and prospects for BMVs as SDDSs and highlight their potential in revolutionizing the fields of nanomedicine and drug delivery. In conclusion, this review paper aims to provide a comprehensive overview of the state-of-the-art field of BMVs as SDDSs, encompassing their design, composition, fabrication, purification, and characterization, as well as the various strategies used for targeted delivery. Considering this information, the aim of this review is to provide researchers in the field with a comprehensive understanding of the current state of BMVs as SDDSs, enabling them to identify critical gaps and formulate new hypotheses to accelerate the progress of the field.

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Capecitabine-loaded bacterial membrane vesicles derived from Enterococcus faecalis promotes apoptosis in HT-29 colon cancer cells

Cited by 3 publications

References 46 publications

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals

The relationship between bacterial outer membrane vesicles and halophilic adaptation

Bacterial Membrane Vesicles as Smart Drug Delivery and Carrier Systems: A New Nanosystems Tool for Current Anticancer and Antimicrobial Therapy

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