Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections

Oliveira, Ludmila Fernandes; Souza, Márcia María de; Andrade, Zilton A.

doi:10.1590/s0037-86822004000200001

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Similar lines of evidences have been produced for the septal fibrosis as- sociated with C. hepatica infection of rats (Lemos et al 2003), but the immunology of C. hepatica infection itself is still poorly understood. Repeated experimental infections have resulted in considerable modifications in the constitution of the focal parasitic lesions, while the dynamics and structure of the septal fibrosis were not much altered (Oliveira et al 2004). During this latter study, the levels of anti-parasite circulating antibodies progressively increased with repeated infections, but that did not prevent the worms to live longer and to produce more eggs, while the process of septal fibrosis maintained its usual course.…”

mentioning

confidence: 70%

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Gomes

Cunha

Bastos

et al. 2006

Mem. Inst. Oswaldo Cruz

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mentioning

confidence: 70%

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Gomes

Cunha

Bastos

et al. 2006

Mem. Inst. Oswaldo Cruz

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“…Laboratory findings in hepatic capillariasis in man are associated with raised levels of alanine aminotransferase and aspartate aminotransferase, and abnormal liver function tests; eosinophilia and leukocytosis in the peripheral blood has also been recorded (Spratt and Singleton 2001;Sun 1999). It is of interest in this context to note the insignificant amount of injury caused by C. hepatica in the liver; in a series of recent reports, hepatic capillariasis in the rat has been proposed as a rodent model for studies on hepatic fibrosis in man (Gomes et al 2006;Oliveira et al 2004;Souza et al 2006aSouza et al , 2006b.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Histopathological Features of Capillaria hepatica Infection in Laboratory Rabbits

Mowat¹,

Turton²,

Stewart³

et al. 2009

Toxicol Pathol

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The above manuscript has been retracted from publication. The following reason was stated:The paper described the pathology associated with what was thought to be a nematode parasite, Capillaria hepatica. The figures that appear in the manuscript show another parasite, Eimeria spp and do not show the nematode. While some of the hepatic pathology described might have been attributed to infection with the Capillaria, the absence of definitive proof meant that the possibility of misleading readers was high and it was, with the agreement of the authors, decided to withdraw the manuscript to avoid this possibility. ABSTRACT Capillaria hepatica is a nematode parasite of wild rodents and other mammals. Adult worms inhabit the liver. Recently, during the necropsy examination of a group of 160 rabbits from a commercial supplier, firm pale or cystic areas (1-5 mm) were noted on the liver in thirteen animals. On further investigation, these animals were found to be infected with C. hepatica. The histopathological features of the infection in the rabbit are described for the first time and diagnostic features recorded. Lesions were identified predominantly in portal tracts consisting of dilated bile ducts with luminal debris, peribiliary inflammatory cell infiltrates, and fibrosis. Large granulomas (macrogranulomas) were evident in portal areas and involved the bile ducts. Macrogranulomas contained collections of characteristic C. hepatica eggs, macrophages, eosinophils, and lymphocytes. Small granulomas (microgranulomas), characterized by epithelioid macrophages surrounded by lymphocytes and eosinophils, were also identified. C. hepatica eggs were also observed in the lumina of the bile ducts and gall bladder. No adult C. hepatica worms were identified. Oocysts of Eimeria stiedae were also evident in the biliary epithelium in some animals. The unique characteristics of the C. hepatica life cycle are described, and the differential diagnosis of hepatic capillariasis is discussed.

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“…Uma vez no ambiente, os ovos não embrionados necessitam de cerca de 28 dias, sob condições adequadas de temperatura e umidade, para se tornarem infectantes 11,12 (embrionados) .…”

Section: Introductionunclassified

Capillaria hepatica (Bancroft, 1893) (Nematoda) entre populações indígenas e mamíferos silvestres no noroeste do Estado do Mato Grosso, Brasil, 2000

et al. 2011

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Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections

Abstract: Multiple exposures to parasitic agents are considered an important factor in the genesis

Cited by 12 publications

References 14 publications

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

RETRACTED: Histopathological Features of Capillaria hepatica Infection in Laboratory Rabbits

Capillaria hepatica (Bancroft, 1893) (Nematoda) entre populações indígenas e mamíferos silvestres no noroeste do Estado do Mato Grosso, Brasil, 2000

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