Capillaroscopy

Trautinger, Franz

doi:10.1111/ddg.12137

Cited by 17 publications

(23 citation statements)

References 20 publications

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“…For this the nailfolds of the fingers, where the capillaries run parallel to the skin surface and can be evaluated in their entire architecture, are particularly suitable. 3 Capillaroscopy may be performed with a lens with low (e.g., 20) and with high magnification (e.g., 200). The instruments with low magnification allow a global and a panoramic evaluation of the entire nailfold area (wide-field capillaroscopy).…”

Section: Techniquementioning

confidence: 99%

Nailfold videocapillaroscopy in internal medicine

et al. 2015

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Capillaroscopy is an actual inexpensive imaging technique, used to examine, non-invasively and safely, the morphology of nailfold dermal papillary capillaries. Many studies agree in the statement that the capillaroscopy is one of the gold standard methods for non-invasive examination of the microcirculation and it plays an important role in screening in Raynaud’s phenomenon and in monitoring of systemic sclerosis and other rheumatologic diseases. There are also many reports on the possible use of nailfold capillaroscopy in the diagnosis and monitoring of many other diseases in internal medicine.

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Section: Techniquementioning

confidence: 99%

Nailfold videocapillaroscopy in internal medicine

et al. 2015

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“…NCM has signifi cantly improved the identifi cation of clinical diff erences (84), and that is why diagnostic sensitivity of ACR criteria may be markedly improved by addition of simple clinical variables, including NCM abnormalities and ACA positivity, as novel minor criteria (83). Capillary patterns may correlate with visceral involvement and capillaroscopy thus has the potential as a screening tool to enable early diagnosis of organ involvement in systemic sclerosis, as well as early therapy and prevention of disease progression (85). Th is method allows: early diagnosis of systemic sclerosis without skin involvement, diff erentiation of primary RPh from secondary RPh and follow up of disease progression (86).…”

Section: Th E Diagnosis Of Systemic Sclerosis Is Based On the Followimentioning

confidence: 99%

CREST Syndrome - a Limited Form of Systemic Scleroderma: a Case Report and Literature Review

Paravina

Stanojević

Spalević

et al. 2015

Serbian Journal of Dermatology and Venereology

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Systemic scleroderma (SSc) is a multisystem disease with microvascular abnormalities, autoimmune disorders, excessive collagen production and deposition, and fibrosis of the skin and internal organs. According to the simplest, though incomplete classification, there are two forms of SSc: diffuse and limited (formerly acrosclerosis). CREST syndrome is a subtype of limited SSc, characterized by: calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. We present a patient with all the features of the CREST syndrome, which appeared at the age of 43 and lasted for 23 years. The patient presented with a gradual development of symptoms during the first ten years, from Raynaud’s phenomenon, skin sclerosis, calcinosis, telangiectasia, and esophageal dysmotility. The diagnosis was based on clinical findings and relevant diagnostic procedures. The article presents a literature review on the epidemiology, etiology, pathophysiology, clinical manifestations, various attempts at classification, diagnostic criteria, and therapeutic modalities. When classifying systemic scleroderma into two main types — diffuse and limited, with CREST syndrome as a variant of the latter, it should be pointed out that both types represent clinical forms of systemic sclerosis, share similar visceral involvement, laboratory abnormalities and course which is variable, as was the case in our patient.

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“…Capillaroscopy, the microscopic evaluation of capillary organization and microvascular blood flow, is a century old technique that has shown value in a variety of clinical fields. The evaluation of nailfold capillary morphology to assess Raynaud's disease and systemic sclerosis is an established clinical technique, capillary tortuosity and blood velocity are significantly correlated with diabetic retinopathy severity, and capillary plexus visibility has been shown to correlate even with seemingly distant disease processes such as schizophrenia [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy

McKay¹,

Mohan²,

Butterworth³

et al. 2020

Biomed. Opt. Express

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Quantification of optical absorption gaps in nailfold capillaries has recently shown promise as a non-invasive technique for neutropenia screening. Here we demonstrate a low-cost, portable attachment to a mobile phone that can resolve optical absorption gaps in nailfold capillaries using a reverse lens technique and oblique 520nm illumination. Resolution <4µm within a 1mm 2 on-axis region is demonstrated, and wide field of view (3.5mm × 4.8mm) imaging is achieved with resolution <6µm in the periphery. Optical absorption gaps (OAGs) are visible in superficial capillary loops of a healthy human participant by an ∼8-fold difference in contrast-to-noise ratio with respect to red blood cell absorption contrast. High speed video capillaroscopy up to 240 frames per second (fps) is possible, though 60fps is sufficient to resolve an average frequency of 37 OAGs/minute passing through nailfold capillaries. The simplicity and portability of this technique may enable the development of an effective non-invasive tool for white blood cell screening in point-of-care and global health settings.

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Capillaroscopy

Cited by 17 publications

References 20 publications

Nailfold videocapillaroscopy in internal medicine

Nailfold videocapillaroscopy in internal medicine

CREST Syndrome - a Limited Form of Systemic Scleroderma: a Case Report and Literature Review

Visualization of blood cell contrast in nailfold capillaries with high-speed reverse lens mobile phone microscopy

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