Capillaroscopy shows an active pattern of scleroderma in coeliac disease

Thonhofer, Renè; Trummer, Markus; Siegel, Cornelia

doi:10.3109/03009742.2010.489230

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…These findings are similar to NVC findings seen in scleroderma. In a single-case publication presented by R.Thonhofer et al, it was found that an active scleroderma pattern was detected in the capillaroscopy measurement performed in a patient diagnosed with GE, and NVC measurements were found to improve with the removal of gluten from the diet (15). This single case presentation on this subject, which can be found in the literature review, supports the results of our study.…”

Section: Discussionsupporting

confidence: 91%

“…This inflammatory response may also be causing damage at the capillary level. It is known that the level of serum a-TTG is related to the degree of villous atrophy (15). In the evaluation of these patients, it was determined that all 21 patients with capillary disorders were in the active AGE group, and antibody positivity was shown in all active patients.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Gluten Enteropathy and Nail Capileroscopy Findings and Disease Activation

Okyar

Yıldırım

Barutçu

2022

Clinical and Experimental Health Sciences

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Objective: Nailfold Videocapilloroscopy (NVC) is an examination method that is used as an aid in the diagnosis, follow-up, and treatment strategy of rheumatic diseases such as systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and gives an idea about microcirculation by examining the vascular bed. It is a cheap, easily applicable, and quickly accessible method. Because of these features, we aimed to use the NVC method in patients with Gluten Enteropathy (GE) to determine whether this method will be a helpful technique in the diagnosis, activation decision, remission follow-up, and treatment strategy in patients with GE. Methods: In this study, 67 patients diagnosed with GE (n=35 disease-active group (AGE), n=32 disease-related remission group (RGE), and control group (CG)-27 healthy people whose diagnosis of GE was ruled out were included in this study. Group and CG were divided into ten parameters in capillary pathologies (capillary density loss, dilated capillary, giant capillary, microhemorrhage, avascular area, tortuosity, branched capillary, disorganization, extravasation, angiogenesis). They were divided into two groups as RGE and compared with the results obtained from NVC measurements Results: When patients diagnosed with GE and CG were evaluated in terms of capillary disorder with NVC, While all of the patients with capillary disorders were in the GE group, no capillary disorders were found in the control group (p

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gluten Enteropathy and Nail Capileroscopy Findings and Disease Activation

Okyar

Yıldırım

Barutçu

2022

Clinical and Experimental Health Sciences

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“…In our previous study, the endomysial antibody was more frequently positive in patients with SLE than in controls, particularly those with discoid lesions (31) . Raynaud phenomenon was observed in two patients; both showed the classic tricolor phenomenon and symmetrical bilateral involvement of hands and feet (32) . No other autoimmune rheumatic disease was detected.…”

Section: Discussionmentioning

confidence: 93%

Immune Mediated Diseases in Patients With Celiac Disease and Their Relatives: A Comparative Study of Age and Sex

Kotze

Moreno

et al. 2018

Arq. Gastroenterol.

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BACKGROUND: Up to 15% of other immune-mediated diseases (IMDs) can occur in patients with CD throughout their lives and are associated with multiple factors, including sex and sex hormone levels. Moreover, sex is associated with differences in clinical presentation, onset, progression, and outcomes of disorders. OBJECTIVE: To investigate the prevalence of IMDs at diagnosis in patients with celiac disease (CD) and their first-degree relatives and to compare the findings between female and male patients of different age. METHODS: A retrospective study including Brazilian patients with CD who visited the same doctor during January 2012 to January 2017 was performed. Demographic and medical history data were collected through self-administered questionnaires and medical charts of the patients. In total, 213 patients were examined at diagnosis: 52 males (mean age, 40.0 years) and 161 females (mean age, 41.4 years). The patients were divided into two groups according to sex and age. RESULTS: IMDs were observed in 60.2% of the female (97/161) and 42.3% of the male patients (22/52; P=0.22). However, the frequency of IMDs was significantly higher in females aged 51-60 years than in males with same age (P=0.0002). Dermatitis herpetiformis (DH) was significantly more prevalent in males (P=0.02), whereas atopy was more prevalent in females (P=0.02). IMDs observed in first-degree relatives were similar to those observed in patients (70.9%; P<0.001), with a higher number observed in female relatives. CONCLUSION: The frequency of IMDs in CD patients was similar in all age groups and both sexes, except women diagnosed with CD after 51 years of age presented with an increased frequency of IMDs compared with males. Dermatitis herpetiformis was more prevalent in males, whereas atopy was more prevalent in females. No difference was observed in the type of IMDs between the first-degree relatives of both sexes.

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“…Moreover, the strong immunoinflammatory activation observed in active CD that triggers the chronic release of several cytokines endowed with vasoactive properties (interferon-gamma and interleukin-2, -4, -10) might affect arterial regulation in predisposed patients (8). There are reports indicating a reduction in Raynaud's phenomenon after the introduction of a GFD and vitamin reposition (9,10).…”

Section: Discussionmentioning

confidence: 99%

Rare association of celiac disease with myasthenia gravis in a patient with other immune disorders: A case report

Menezes¹,

Cabral²,

Lorena³

et al. 2016

Rev Esp Enferm Dig

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Background: Celiac disease is described in association with several autoimmune diseases, but rarely with myasthenia gravis.Case report: We describe the case of a 31-year-old white woman with celiac disease who presented manifestations related to a hyperactive immune system, including macroamylasemia, falsepositive anti-HCV, positive antinuclear antibody, and Raynaud's phenomenon. The introduction of a gluten-free diet (GFD) resolved these features, but myasthenia gravis (MG) symptoms unexpectedly occurred on that occasion.Discussion: The role of a GFD in the course of autoimmune diseases has been studied and improvement has been reported in many diseases. However, there is no consensus in the literature regarding the course of neurological disorders associated with celiac disease. In the present case, a GFD did not prevent the appearance of symptoms related to myasthenia gravis. There are few reports on the association of celiac disease with myasthenia gravis and therefore little is known about the course and time of onset of myasthenia in celiac patients. The present case increases the knowledge about this unusual autoimmune neurological disease associated with celiac disease.

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Capillaroscopy shows an active pattern of scleroderma in coeliac disease

Cited by 4 publications

References 9 publications

The Relationship Between Gluten Enteropathy and Nail Capileroscopy Findings and Disease Activation

The Relationship Between Gluten Enteropathy and Nail Capileroscopy Findings and Disease Activation

Immune Mediated Diseases in Patients With Celiac Disease and Their Relatives: A Comparative Study of Age and Sex

Rare association of celiac disease with myasthenia gravis in a patient with other immune disorders: A case report

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