Capillary Electrochromatography

Yan, Chao; Xue, Yifeng; Wang, Yan

doi:10.1016/b978-0-12-809375-7.00009-5

Cited by 6 publications

(3 citation statements)

References 137 publications

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“…Except for employing a detector with high sensitivity, other approaches to achieve good detection sensitivity, as well as resolution and separation efficiency, include bubble or Z-type cells to extend the optical path, and obviously sample preconcentration techniques. For instance, FASS and in-column detection [ 131 , 132 ]. CEC was reported for the fast separation and quantification of coumarins in Angelica dahurica extract.…”

Section: Resultsmentioning

confidence: 99%

Recent Applications of Capillary Electrophoresis in the Determination of Active Compounds in Medicinal Plants and Pharmaceutical Formulations

et al. 2021

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The present review summarizes scientific reports from between 2010 and 2019 on the use of capillary electrophoresis to quantify active constituents (i.e., phenolic compounds, coumarins, protoberberines, curcuminoids, iridoid glycosides, alkaloids, triterpene acids) in medicinal plants and herbal formulations. The present literature review is founded on PRISMA guidelines and selection criteria were formulated on the basis of PICOS (Population, Intervention, Comparison, Outcome, Study type). The scrutiny reveals capillary electrophoresis with ultraviolet detection as the most frequently used capillary electromigration technique for the selective separation and quantification of bioactive compounds. For the purpose of improvement of resolution and sensitivity, other detection methods are used (including mass spectrometry), modifiers to the background electrolyte are introduced and different extraction as well as pre-concentration techniques are employed. In conclusion, capillary electrophoresis is a powerful tool and for given applications it is comparable to high performance liquid chromatography. Short time of execution, high efficiency, versatility in separation modes and low consumption of solvents and sample make capillary electrophoresis an attractive and eco-friendly alternative to more expensive methods for the quality control of drugs or raw plant material without any relevant decrease in sensitivity.

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Section: Resultsmentioning

confidence: 99%

Recent Applications of Capillary Electrophoresis in the Determination of Active Compounds in Medicinal Plants and Pharmaceutical Formulations

et al. 2021

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“…As a practical application of CE on NIE-modified capillaries, the determination of a number of catecholamines and amino acids [ 33 ] or a few inorganic anions [ 28 ] in human urine was demonstrated. In another report by the same research group [ 29 ], a similar but positively charged NIE was proven as a feasible pseudostationary phase for CEC, another powerful electromigration technique for the separation of a variety of analytes [ 70 ]. To cope with the modest durability of NIE coatings, a layer-by-layer approach was recently proposed [ 34 ] in which the capillary inner wall is sequentially coated with two layers of oppositely charged NIEs.…”

Section: Applicationsmentioning

confidence: 99%

Nanoscale Ion-Exchange Materials: From Analytical Chemistry to Industrial and Biomedical Applications

Matczuk,

Ruzik,

Keppler

et al. 2023

Molecules

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Nano-sized ion exchangers (NIEs) combine the properties of common bulk ion-exchange polymers with the unique advantages of downsizing into nanoparticulate matter. In particular, being by nature milti-charged ions exchangers, NIEs possess high reactivity and stability in suspensions. This brief review provides an introduction to the emerging landscape of various NIE materials and summarizes their actual and potential applications. Special attention is paid to the different methods of NIE fabrication and studying their ion-exchange behavior. Critically discussed are different examples of using NIEs in chemical analysis, e.g., as solid-phase extraction materials, ion chromatography separating phases, modifiers for capillary electrophoresis, etc., and in industry (fuel cells, catalysis, water softening). Also brought into focus is the potential of NIEs for controlled drug and contrast agent delivery.

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“…By applying voltage, the EOF is generated and it carries the mobile phase with analytes through the capillary. The charged compounds are separated not only by their different electrophoretic mobilities but also due to their distribution between the mobile and the liposomal stationary phases [ 60 – 62 ]. To coat the capillary wall with liposomes, the capillary can be simply flushed by them, or the avidin–biotin technique can be used.…”

Section: Liposomes and Capillary Electrophoresismentioning

confidence: 99%

Liposomes: preparation and characterization with a special focus on the application of capillary electrophoresis

2022

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Liposomes are nowadays a matter of tremendous interest. Due to their amphiphilic character, various substances with different properties can be incorporated into them and they are especially suitable as a model system for controlled transport of bioactive substances and drugs to the final destination in the body; for example, COVID-19 vaccines use liposomes as a carrier of mRNA. Liposomes mimicking composition of various biological membranes can be prepared with a proper choice of the lipids used, which proved to be important tool in the early drug development. This review deals with commonly used methods for the preparation and characterization of liposomes which is essential for their later use. The alternative capillary electrophoresis methods for physico-chemical characterization such as determination of membrane permeability of liposome, its size and charge, and encapsulation efficiency are included. Two different layouts using liposomes to yield more efficient separation of various analytes are also presented, capillary electrochromatography, and liposomal electrokinetic chromatography. Graphical abstract

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Capillary Electrochromatography

Cited by 6 publications

References 137 publications

Recent Applications of Capillary Electrophoresis in the Determination of Active Compounds in Medicinal Plants and Pharmaceutical Formulations

Recent Applications of Capillary Electrophoresis in the Determination of Active Compounds in Medicinal Plants and Pharmaceutical Formulations

Nanoscale Ion-Exchange Materials: From Analytical Chemistry to Industrial and Biomedical Applications

Liposomes: preparation and characterization with a special focus on the application of capillary electrophoresis

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