Capillary gas chromatographic method for determination of flumecinol in plasma and saliva

Klebovich, Imre; Kapás, Margit; Vereczkey, L.

doi:10.1016/s0378-4347(00)80940-8

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“…Numerous gas chromatography (GC) procedures have been reported for the analysis of BZP [10][11][12][13], including NPD and ECD detectors. Generally, capillary GC coupled to mass spectrometry (MS) is the method of choice for most of the toxicological analysis.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography–electrospray ionisation mass spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid

Quintela

Cruz

Castro

et al. 2005

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Liquid chromatography–electrospray ionisation mass spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid

Quintela

Cruz

Castro

et al. 2005

Journal of Chromatography B

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Metabolism of flumecinol in humans

et al. 1987

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1. The metabolism of 14C-flumecinol (3-trifluoromethyl-alpha-ethyl-benzhydrol) was studied in volunteers after a single oral dose of 100 mg (11.1 MBq; 300 microCi). Radioactivity excreted in urine was 78.8 +/- 6.0% of dose and in faeces was 12.0 +/- 5.3% dose in 120 h. 2. Unchanged flumecinol was not excreted in urine, but was present in faeces unconjugated (1.2% dose) and as conjugates of glucuronic and sulphuric acids (10.8% dose). 3. Enzymic hydrolysis showed that all urinary metabolites were conjugated with glucuronic and/or sulphuric acids (77.8% dose). Unconjugated urinary metabolites were not found. 4. The major route of flumecinol metabolism was hydroxylation of the alkyl side chain and/or the phenyl group followed by conjugation. 5. Both the CF3-group and the skeleton of the original compound remained intact during metabolism.

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Capillary gas chromatographic method for determination of flumecinol in plasma and saliva

Cited by 2 publications

References 3 publications

Liquid chromatography–electrospray ionisation mass spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid

Liquid chromatography–electrospray ionisation mass spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid

Metabolism of flumecinol in humans

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