Capillary leak syndrome: State of the art in 2021

Bichon, Amélie; Bourenne, Jérémy; Gainnier, Marc; Carvelli, Julien

doi:10.1016/j.revmed.2021.05.012

Cited by 26 publications

(38 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Capillary leak syndrome acute episode consists of three phases: first it begins with the prodromal phase which is characterized by conventional nonspecific symptoms and deterioration of the general status, i.e., flu-like symptoms including cough, myalgia, and rhinorrhea, in addition to digestive symptoms including abdominal pain, vomiting and diarrhea [ 15 ]. Subsequently, a sudden and a conceivably fatal hypovolemia occurs during the leak phase which is portrayed by weight gain and generalized edema.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, a sudden and a conceivably fatal hypovolemia occurs during the leak phase which is portrayed by weight gain and generalized edema. The consequences are numerous and serious, ranging from hypovolemic shock and cardiac arrest to multiple organ dysfunction syndrome and systemic inflammatory response syndrome [ 15 ]. Ultimately, a post-leak phase with restoration of blood pressure and abolishment of edema with massive polyuria commences.…”

Section: Discussionmentioning

confidence: 99%

“…Ultimately, a post-leak phase with restoration of blood pressure and abolishment of edema with massive polyuria commences. However, a distinguishable pulmonary edema, which is often fatal, is elicited by the iatrogenic fluid overload used in the management [ 15 ]. The diagnosis of SCLS is purely clinical since there are no specific biomarkers or diagnostic tests [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…SCLS can be idiopathic which is generally known as Clarkson’s disease. Yet, it can be secondary to multiple factors, including drugs, malignancies, infections, and autoimmune diseases, with 44% of cases having a recognizable cause behind the attacks [ 13 , 15 ]. Multiple drugs have been found to provoke SCLS, Mertz et al.…”

Section: Discussionmentioning

confidence: 99%

“…Incidentally, SCLS can be the presenting manifestation of a malignancy, e.g., in the literature, cases of anaplastic large cell lymphoma, large B‑cell lymphoma, and T‑cell lymphoma have been reported as initially presenting with SCLS [ 25 – 27 ]. Viral infections explicitly have been linked to SCLS including Ebola, dengue, Hantaviruses, Marburg, influenza A and more recently SARS-CoV‑2 (severe acute respiratory syndrome coronavirus 2) [ 15 ]. Concerning autoimmune and autoinflammatory diseases, psoriasis has been the most commonly reported, followed by systemic lupus erythematosus and antiphospholipid syndrome [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Systemic capillary leak syndrome following granulocyte colony-stimulating factor therapy in a T-lymphoblastic leukemia/lymphoma patient: a case report

Sharie

Zu’bi

Sharie

et al. 2022

memo

View full text Add to dashboard Cite

Introduction Systemic capillary leak syndrome (SCLS) is a rare and often fatal clinical entity used to describe a generalized increase in vascular permeability leading to fluid extravasation toward the interstitial compartment. SCLS could be an idiopathic disease or secondary to infections, malignancies or drugs. Case We present a case of presumably granulocyte colony-stimulating factor (G-CSF)-induced SCLS in a 21-year-old man diagnosed with T‑lymphoblastic leukemia/lymphoma. He received the 6th cycle (part B) of the hyper-CVAD chemotherapeutic regimen followed by the initiation of neutropenic fever prophylaxis protocol which included antibiotics and G‑CSF. In a course of hours, the patient became dyspneic, hypotensive, and edematous which required intensive care unit admission and was stabilized accordingly. In the following days the patient’s anasarca progressively increased which was associated with hypoalbuminemia, hypotension and anemia with pericardial and bilateral plural effusions. As a diagnosis of exclusion augmented by the acuity of such clinical event, observed concomitantly with the administration of the prophylaxis protocol, the suspicion of G‑CSF-induced SCLS was established. Consequently, G‑CSF was discontinued and treatment with dexamethasone and intravenous immunoglobulins (IVIG) was started. The patient’s condition improved significantly illustrated by hemodynamic stability in addition to improvement regarding the anasarca, hypoalbuminemia, and anemia. Follow-up scans suggest resolution of the pericardial and plural effusions. Conclusion SCLS remains a serios and potentially fatal complication of G‑CSF administration which should be taken into consideration, since such medication is widely utilized in oncology wards.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Systemic capillary leak syndrome following granulocyte colony-stimulating factor therapy in a T-lymphoblastic leukemia/lymphoma patient: a case report

Sharie

Zu’bi

Sharie

et al. 2022

memo

View full text Add to dashboard Cite

show abstract

Microfluidics as a Powerful Tool to Investigate Microvascular Dysfunction in Trauma Conditions: A Review of the State‐of‐the‐Art

Bathrinarayanan,

Hallam,

Grover

et al. 2024

Advanced Biology

View full text Add to dashboard Cite

Skeletal muscle trauma such as fracture or crush injury can result in a life‐threatening condition called acute compartment syndrome (ACS), which involves elevated compartmental pressure within a closed osteo‐fascial compartment, leading to collapse of the microvasculature and resulting in necrosis of the tissue due to ischemia. Diagnosis of ACS is complex and controversial due to the lack of standardized objective methods, which results in high rates of misdiagnosis/late diagnosis, leading to permanent neuro‐muscular damage. ACS pathophysiology is poorly understood at a cellular level due to the lack of physiologically relevant models. In this context, microfluidics organ‐on‐chip systems (OOCs) provide an exciting opportunity to investigate the cellular mechanisms of microvascular dysfunction that leads to ACS. In this article, the state‐of‐the‐art OOCs designs and strategies used to investigate microvasculature dysfunction mechanisms is reviewed. The differential effects of hemodynamic shear stress on endothelial cell characteristics such as morphology, permeability, and inflammation, all of which are altered during microvascular dysfunction is highlighted. The article then critically reviews the importance of microfluidics to investigate closely related microvascular pathologies that cause ACS. The article concludes by discussing potential biomarkers of ACS with a special emphasis on glycocalyx and providing a future perspective.

show abstract