Capillary supercritical fluid chromatography

Fjeldsted, John C.; Lee, Milton L.

doi:10.1021/ac00268a004

Cited by 115 publications

(45 citation statements)

References 16 publications

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“…The helium carrier gas flow rate was 15 mL/min, the injector temperature was 300 OC, and the flame ionization detector temperature was 350 "C. analyzed according to the procedure outlined above. The SFC apparatus (21,22) used in this study was a Lee Scientific Model 501 (Salt Lake City, UT) equipped with a flame ionization detector (FID). Supercritical fluid grade carbon dioxide (Scott Specialty Gases, Plumsteadville, PA) was used as the mobile phase.…”

Section: Analysis Of Solanesol Collected On Quartz Filtersmentioning

confidence: 99%

Solanesol: a tracer for environmental tobacco smoke particles

Tang¹,

Richards²,

Benner³

et al. 1990

Environ. Sci. Technol.

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Concern about the health effects of passive smoking and exposure of a large population to environmental tobacco smoke have generated the need for a quantitative tracer of environmental tobacco smoke. Solanesol, a trisesquiterpenoid alcohol, has been shown to be present in environmental tobacco smoke. Results from the determination of particulate-phase solanesol in environmental tobacco smoke in both chamber and indoor environments show that solanesol is a suitable tracer for the particulate phase of environmental tobacco smoke.

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Section: Analysis Of Solanesol Collected On Quartz Filtersmentioning

confidence: 99%

Solanesol: a tracer for environmental tobacco smoke particles

Tang¹,

Richards²,

Benner³

et al. 1990

Environ. Sci. Technol.

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“…The researcher should also be aware of new technology such as micro-HPLC [15] and supercritical fluid chromatographic [16], as these will have obvious applications in the future nca radiolabeling of compounds. It is an essential tool in the developmental stage of nca radiolabeled compounds.…”

Section: Discussionmentioning

confidence: 99%

Development of No-Carrier-Added Radiopharmaceuticals with the Aid of Radio-HPLC

Wilbur¹

1986

Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry

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INTRODUCTIONThe single most important tool for the development of high specific activity or no-carrier-added (nca) radiopharmaceuticals is a radio-HPLC. The reason for making such a strong statement in favor of HPLC rather than other chromatographic methods is that HPLC offers many advantages over other chromatographic methods. For example, the columns employed in HPLC are much more efficient than conventional thin-layer chromatography (TLC) plates, and the isolation of the products is simpler, more convenient, and safer than either TLC or gas chromatography.Radiolabeling molecules to obtain compounds with very high specific activities is of particular interest for receptor-binding radiopharmaceuticals [1]. Unfortunately, radiolabeling molecules with high specific activity (e.g., nocarrier-added) radionuclides can often be difficult and frustrating. Reactions that are quite facile using stoichiometric quantities of reagents can, and often do, give significantly different results when no-carrier-added levels of a radionuclide are used. Thus, it nearly always takes a large amount of work changing reaction conditions to optimize a no-carrier-added radiolabeling reaction yield. The use of radio-HPLC can shorten the time required for optimizing the reaction conditions by rapid monitoring of the results of a Abbreviations: High performance liquid chromatography, HPLC; Thin-layer chromatography,

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“…Swelling factor, SF, will be defined as the relative expansion of the stationary-phase volume (2) where V,* is the volume of swollen stationary phase and V, is the original stationary-phase volume.…”

Section: Methodsmentioning

confidence: 99%

Stationary-phase phenomena in capillary supercritical fluid chromatography

Springston¹,

David²,

Steger³

et al. 1986

Anal. Chem.

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1) Giddings, J. C.; Myers, M. N . Sep. Sci. Techno/. 1978, 73, 637. (2) Giddings, J. C.; Myers, M. N.; Caldwell, K. D.; Pav, J . W. J . Chroma-(3) Caldwell, K. D.; Nguyen, T. T.; Myers, M. N.; Giddings, J. C. Sep. Sci. fogr. 1979, 785, 261.Caplllary supercritical fluid chromatography was used to facllltate physlcochemlcal measurements assoclated with statlonary-phase effects. A technique Is described for determlnatlon of swelling of nonextractable polymer fllms In the presence of a supercritlcal fluid. Appreciable swelllng factors were measured for the stationary-phase SE-30 In supercritical butane, while decreased swelllng was observed when carbon dloxide was used. Addltional swelling measurements In butane at a varlety of temperatures and densltles are reported. Impllcatlons of these phenomena are discussed In terms of kinetic column effects and chromatographic performance.

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Capillary supercritical fluid chromatography

Cited by 115 publications

References 16 publications

Solanesol: a tracer for environmental tobacco smoke particles

Solanesol: a tracer for environmental tobacco smoke particles

Development of No-Carrier-Added Radiopharmaceuticals with the Aid of Radio-HPLC

Stationary-phase phenomena in capillary supercritical fluid chromatography

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