Capillary zone electrophoresis for the determination of dissociation constants

Enantiomeric analysis of baclofen analogs by capillary zone electrophoresis, using highly sulfated cyclodextrins: Inclusion ionization constant pKa determination

“…Furthermore, this method requires small amounts of sample at low solute concentration without the knowledge of its exact value. Potential impurities do not interfere with the calculation of pK a , which is based on the migration time exclusively without peak quantification [18]. In this study, the electrophoretic behavior of the series of GABA derivatives was investigated using CE with direct UV detection in a BGE adjusted to different pH values.…”

Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques

“…An intermediate mobility is a function of its dissociation equilibrium; pKa values can be determined by regression analysis. 14 In this study we aimed at measuring the pKa values of epiboxidine 2 and those of its structurally related compounds 4 -8, 8 as well as of epibatidine analogues 9 -11 and derivatives 12 -16, the latter belonging to a group of recently patented 2010 © The Japan Society for Analytical Chemistry † To whom correspondence should be addressed. E-mail: gabriella.roda@unimi.it analogues of ARR1779 10 ( Fig.…”

Determination of dissociation constants of amino acids by capillary zone electrophoresis

“…Less than a 0.07 difference between the determined pK a value with the corresponding literature value was obtained when the pK a value of the analyte is less than 9. There were significant differences between the literature pK a values and the determined pK a values for bases with dissociation constants above 9 [19]. An automated method for obtaining the pK a values of acids and bases using CE was described and is suitable for determining the pK a value of compound with low water solubility [20].…”