Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action

Chen, Kuo-Shuen; Chen, Pei‐Ni; Hsieh, Yih‐Shou; Chen, Lin; Lee, Yi-Hsun; Chu, Shu‐Chen

doi:10.1016/j.cbi.2015.01.007

Cited by 41 publications

(22 citation statements)

References 28 publications

(55 reference statements)

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“…Numerous studies have demonstrated that CAP has extensive bioactivities, such as analgesic [8], antioxidant [9], anti-inflammatory, anti-cancer [10], and anti-obesity properties [11,12]. In addition, the CAP is known to increase energy metabolism by proposed mitochondrial function via activation of the TRPV1 (transient receptor potential vanilloid 1) [12].…”

Section: Introductionmentioning

confidence: 99%

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

et al. 2016

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Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge. Female Institute of Cancer Research (ICR) mice from four groups (n = 8 per group) were orally administered CAP for 4 weeks at 0, 205, 410, and 1025 mg/kg/day, which were respectively designated the vehicle, CAP-1X, CAP-2X, and CAP-5X groups. The anti-fatigue activity and exercise performance was evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, BUN (blood urea nitrogen) and creatine kinase (CK) after a 15-min swimming exercise. The grip strength and exhaustive swimming time of the CAP-5X group were significantly higher than other groups. CAP supplementation dose-dependently reduced serum lactate, ammonia, BUN and CK levels, and increased glucose concentration after the 15-min swimming test. In addition, CAP also increased hepatic glycogen content, an important energy source for exercise. The possible mechanism was relevant to energy homeostasis and the physiological modulations by CAP supplementation. Therefore, our results suggest that CAP supplementation may have a wide spectrum of bioactivities for promoting health, performance improvement and fatigue amelioration.

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Section: Introductionmentioning

confidence: 99%

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

et al. 2016

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“…It has also been observed that anti-inflammatory capsaicin can protect against endothelial injury. 44 In this study, anti-inflammatory CUR was embedded in the liposomal bilayer and improved the viability of HBMECs, HAs, and HBVPs, showing a difference between this work and a recent publication. 23 Permeability of NgF and cUr across hBMec/ha using Wga-cl-NgF-cUrliposomes Figure 8 shows the permeability of NGF and CUR across HBMEC/HA.…”

mentioning

confidence: 55%

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

Kuo¹,

Lin²

2015

IJN

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Liposomes with cardiolipin (CL) and wheat germ agglutinin (WGA) were developed to permeate the blood–brain barrier and treat Alzheimer’s disease. WGA-conjugated and CL-incorporated liposomes (WGA-CL-liposomes) were used to transport nerve growth factor (NGF) and curcumin (CUR) across a monolayer of human brain-microvascular endothelial cells regulated by human astrocytes and to protect SK-N-MC cells against apoptosis induced by β-amyloid 1–42 (Aβ 1–42 ) fibrils. An increase in the CL mole percentage in lipids increased the liposomal diameter, absolute zeta potential value, entrapment efficiency of NGF and CUR, release of NGF, biocompatibility, and viability of SK-N-MC cells with Aβ 1–42 , but decreased the atomic ratio of nitrogen to phosphorus and release of CUR. In addition, an increase in the WGA concentration for grafting enhanced the liposomal diameter, atomic ratio of nitrogen to phosphorus, and permeability of NGF and CUR across the blood–brain barrier, but reduced the absolute zeta potential value and biocompatibility. WGA-CL-liposomes carrying NGF and CUR could be promising colloidal delivery carriers for future clinical application in targeting the blood–brain barrier and inhibiting neurotoxicity.

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“…They thereby play an important role in the pathogenesis and progression of atherosclerosis by facilitating inflammation and lipid deposition (Trpkovic et al, 2015;Lundqvist et al, 2015). Macrophages can differentiate into the M1 and M2 types, which can be inter-transformed depending on the body's microenvironment (Medbury et al, 2014;Chen et al, 2015). In atherosclerotic plaques, both M1 and M2 macrophages exist, although they are responsible for distinct functions (Fadini et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis

et al. 2016

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ABSTRACT.As an anti-inflammatory cytokine, interleukin-37 (IL-37) provides certain protective effects against inflammatory and autoimmune diseases. Recent reports indicate that IL-37 is expressed in foam cells of atherosclerotic plaques in both the coronary and carotid arteries of humans, suggesting the possible involvement of IL-37 in the pathogenesis and progression of atherosclerosis. Current evidence supports the protective role that IL-37 plays against atherosclerosis via the regulation of different subtypes of macrophage. Atherosclerosis was induced in apolipoprotein E -/-mice through diet, and the mice were then given IL-37 to observe patterns in the aorta plaque. Furthermore, human peripheral blood-derived monocytes were cultured for seven days to induce the differentiation of macrophages. Specifically, we observed the effect of IL-37 on oxygenated low density lipoprotein (ox-LDL)-induced macrophage polarity, in addition to conducting an expressional assay of the M1 cell markers tumor necrosis factor (TNF)-α and CD86 and the M2 marker CD206. IL-37 effectively decreased the area ratio between the aorta plaque and vascular cavity. We also observed that M1 macrophages can be induced from peripheral monocytes by ox-LDL, with significant elevation of marker molecules TNF-α and CD86. The co-stimulation of IL-37 and ox-LDL, however, inhibited the induction of M1 cells and facilitated the transformation of macrophages into M2 cells, as supported by the elevation of cellspecific marker CD206. These results indicate that IL-37 can prevent atherosclerosis by modulating macrophage polarity.

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Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action

Cited by 41 publications

References 28 publications

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis

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Capsaicin protects endothelial cells and macrophage against oxidized low-density lipoprotein-induced injury by direct antioxidant action

Cited by 41 publications

References 28 publications

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Rescuing apoptotic neurons in Alzheimer&rsquo;s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis

Contact Info

Product

Resources

About

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin