Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Caetano, Brunno Felipe Ramos; Tablas, Mariana Baptista; Pereira, Natália Elias Ferreira; Moura, Nelci Antunes de; Carvalho, Robson Francisco; Rodrigues, Maria Aparecida Marchesan; Barbisan, Luı́s Fernando

doi:10.1016/j.taap.2017.11.008

Cited by 34 publications

(14 citation statements)

References 70 publications

(71 reference statements)

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“…Pre-clinical studies have demonstrated that capsaicin may be a chemopreventive agent in CRC through anti-proliferative, anti-genotoxic, induced expression of apoptotic genes, and up-regulation of genes involved in cell differentiation [177]. Since previous reports indicated that capsaicin might promote metastasis, acting as co-carcinogen in cancer skin [196] and promoting breast cells metastasis [197].…”

Section: In Vivo Studies In Crc Animal Modelsmentioning

confidence: 99%

Chemoprevention of Colorectal Cancer by Dietary Compounds

Costea

Hudiţă

Ciolac

et al. 2018

IJMS

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Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, obesity, chronic inflammatory bowel diseases). This review will discuss, in detail, the chemopreventive properties of some dietary compounds (phenolic compounds, carotenoids, iridoids, nitrogen compounds, organosulfur compounds, phytosterols, essential oil compounds, polyunsaturated fatty acids and dietary fiber) against colorectal cancer. We present recent data, focusing on in vitro, laboratory animals and clinical trials with the previously mentioned compounds. The chemopreventive properties of the dietary compounds involve multiple molecular and biochemical mechanisms of action, such as inhibition of cell growth, inhibition of tumor initiation, inhibition of adhesion, migration and angiogenesis, apoptosis, interaction with gut microbiota, regulation of cellular signal transduction pathways and xenobiotic metabolizing enzymes, etc. Moreover, this review will also focus on the natural dietary compounds’ bioavailability, their synergistic protective effect, as well as the association with conventional therapy. Dietary natural compounds play a major role in colorectal chemoprevention and continuous research in this field is needed.

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Section: In Vivo Studies In Crc Animal Modelsmentioning

confidence: 99%

Chemoprevention of Colorectal Cancer by Dietary Compounds

Costea

Hudiţă

Ciolac

et al. 2018

IJMS

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“…ACF are well known estimators for colon carcinogenesis which are used as end point marker in cancer chemoprevention interventions and indicators for carcinogenesis. They steadily appear in the normally-appearing colorectal mucosa of colon cancer patients (Ghosh et al, 2018) or after DMH administration in rodents (Caetano, 2018). On the other hand, the inhibitory effects of the ASCex here are accompanied with a significant inhibition in the PCNA-LI (%) in colonic mucosa and in tumors.…”

Section: Discussionmentioning

confidence: 86%

Attenuation of Rat Colon Carcinogenesis by Styela plicata Aqueous Extract. Modulation of NF-κB Pathway and Cytoplasmic Sod1 Gene Expression

Salim

El-Gamal

Mona

et al. 2020

Asian Pac J Cancer Prev

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Objective: In search for a unique natural combination of highly active biological components for treatment against colon cancer, we used aqueous extract of Ascidia, Styela plicata (ASCex), a marine invertebrate depending on its richness of high levels of biologically active components as indicated in our previous studies, against rat colon cancer, exploring its underlying mechanisms. Methods: Rats chemically initiated for colon cancer were either non-treated or post-treated with highly saturated ASCex for 32 weeks after initiation, other groups of rats were administered ASCex without cancer initiation or served as normal controls. Results: Rats treated with ASCex alone did not show any signs of non-favored health conditions. Treatment with ASCex after cancer initiation has significantly reduced the average incidences, multiplicities and volumes of colon tumors (adenomas and adenocarcinomas) as compared with the nontreated cancer group. ASCex has also significantly reduced the total numbers of aberrant crypt foci (ACF), surrogate biomarkers for colon cancer as compared with the non-treated cancer group. Moreover, anti-proliferative celluar nucular antigen (PCNA) immunohistochemical staining revealed that ASCex exerted significant antiproliferative characteristics in the carcinogen-treated colonic mucosa as compared with its corresponding control. Also, treatment with ASCex has markedly down-regulated the mRNA expression levels of Nuclear Factor-kappa B (NF-κB), a nuclear transcriptional activator as well as the mRNA expression of the cytoplasmic SOD1 gene which encodes Cu/Zn SOD, the first line defense against superoxide radicals. Conclusion: Collectively, ASCex could act as a potent chemotherapeutic drug against colon cancer, likely through the influence of its rich active metabolites which interfere with various biological pathways including inhibition of protein synthesis during cellular growth and marked induction of antioxidative capacity in the colonic mucosa. This role has been extensively discussed herein.

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“…Con icting reports exists on antitumoral or carcinogenic effects of capsaicin (Friedman et al, 2019). Some studies have shown that capsaicin at 50mg/kg reduced CRC risk in DMH-induced rats models by inhibiting the cytotoxicity, genotoxicity, proliferation, and apoptosis of cancer cell/tissue (Caetano et al, 2018). They also showed that high dose capsaincin decrease the proportion of tubular .…”

Section: Discussionmentioning

confidence: 99%

Effect of cold exposure and capsaicin on the expression of histone acetylation and Toll-like receptors in 1,2-dimethylhydrazine-induced colon carcinogenesis

Qin

et al. 2021

Environ Sci Pollut Res

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Previous studies have indicated that capsaicin-rich diet and cold weather have showed strong association with tumor incidence. Thus, we investigated the effects of capsaicin and cold exposure in 1,2-dimethylhydrazine-induced colorectal cancer as well as the mechanisms underlying capsaicin and cold induced CRC. Rats were randomly divided into four groups and received cold still water and capsaicin via intragastric gavage until the end of the experiment. The rat's body weight, thymus weight, and food intakes were assessed. Global levels of histone H3K9, H3K18, H3K27, H4K16 acetylation and, histone deacetylase (HDACs) in colon mucosa were assessed by western blot. Expression levels of Tolllike receptors 2 (TLR2) and Toll-like receptors 4 (TLR4) were measured by western-blot and reversetranscriptase quantitative polymerase chain reaction (qPCR). We found that cold and low-does capsaicin increased tumor numbers and multiplicity, although there were no differences in tumor incidence.Additionally, rat exposure of cold water and capsaicin display further higher levels of histone H3 lysine 9 (H3K9AC), histone H3 lysine 18 (H3K18AC), histone H3 lysine 27 (H3K27AC) and HDACs compared with the DMH and normal rats. In contrast, a considerable decrease of histone H4 lysine 16 (H4K16AC) was detected in the colon mucosa. Cold and low-dose capsaicin exposure group were also increased TLR2 and TLR4 proteins levels and mRNA levels. These results suggest that chronic cold exposure and capsaicin at a low-does intervention exacerbate ectopic expression of global histone acetylation and TLR level, which are crucial mechanisms responsible for the progression of colorectal cancer in rat.

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Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Cited by 34 publications

References 70 publications

Chemoprevention of Colorectal Cancer by Dietary Compounds

Chemoprevention of Colorectal Cancer by Dietary Compounds

Attenuation of Rat Colon Carcinogenesis by Styela plicata Aqueous Extract. Modulation of NF-κB Pathway and Cytoplasmic Sod1 Gene Expression

Effect of cold exposure and capsaicin on the expression of histone acetylation and Toll-like receptors in 1,2-dimethylhydrazine-induced colon carcinogenesis

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