Captopril: a free radical scavenger.

Chopra, Mridula; Scott, N.; McMurray, John J.; McLay, JS; Bridges, A. B.; Smith, W. Ewen; Belch, J. J. F.

doi:10.1111/j.1365-2125.1989.tb05384.x

Cited by 107 publications

(49 citation statements)

References 10 publications

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“…Other studies have also reported the ability of captopril to scavenge -OH radicals, 31 as well as exhibit general free radical scavenging activity. 32 In our present study, we also found that in contrast to captopril, the non-SH-containing ACE inhibitor enalaprilat exhibited only slight (nonsignificant) protection, indicating the ACE inhibition may not be the only mechanism of protection by captopril.…”

Section: Discussionsupporting

confidence: 55%

Captopril protects against myocardial injury induced by magnesium deficiency.

1991

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We have previously reported that antioxidant drug intervention protects against magnesium deficiency-induced myocardial lesions. In the present study, Golden Syrian male hamsters were fed either a magnesium-deficient diet or a magnesium-supplemented diet Animals from each group received sulfhydryl-containing angiotensin converting enzyme inhibitors: captopril, epi-captopril (a stereoisomer of captopril), and zofenopril* (arginine blend of zofenopril containing a free SH group); another group of animals received the non-sulfhydryl-containing angiotensin converting enzyme inhibitor enalaprilat The animals were killed after 14 days, and their hearts were isolated for morphological and morphometric analyses. Hematoxylin and eosin-stained sections were examined by a computer image analysis system for a morphometric determination of the severity of myocardial injury. Captopril reduced both the density of lesions, from 0.32 to 0.08 lesions/(mm 2 ) (p<0.01), and the area fraction of lesions, from 7.42xlO" 4 to 2.03 xlO" 4 lesion area/(mm 2 ) (p<0.01), as well as the degree of inflammatory infiltration around the blood vessels. Epi-captopril and zofenopril* were virtually equipotent to captopril, but enalaprilat afforded only slight (nonsignificant) protection. These results indicate that a significant component of the protective effect of captopril in this model was attributable to its sulfhydryl moiety, rather than solely due to the inhibition of the angiotensin converting enzyme. These data further support our previous findings of possible free radical participation in cardiomyopathy due to magnesium deficiency. {Hypertension 1991;18:142-147)

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Section: Discussionsupporting

confidence: 55%

Captopril protects against myocardial injury induced by magnesium deficiency.

1991

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“…ACE inhibitors are applicable in the prevention of hypertension as mentioned by Mark and Davis (2000), which proposed for the treatment of cancer (Lever et al 1999). Consequently, the urgency for natural food-born ACE inhibitors compared to the adverse effects (hypotension, cough, hyperkalemia, headache, dizziness, fatigue, nausea, and renal impairment) of clinically used synthetic ACE inhibitors such as Captopril, have guided to this research (Chopra et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Preparation of bioactive peptides with high angiotensin converting enzyme inhibitory activity from winged bean [Psophocarpus tetragonolobus (L.) DC.] seed

et al. 2013

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Winged bean [Psophocarpus tetragonolobus (L.) DC.] seed is a potential underexploited source of vegetable protein due to its high protein content. In the present work, undefatted and defatted winged bean seed hydrolysates, designated as UWBSH and DWBSH, respectively were produced separately by four proteolytic enzymes namely Flavourzyme, Alcalase, Bromelain, and Papain using pHstat method in a batch reactor. Enzymatic hydrolysis was carried out over a period of 0.5 to 5 h. UWBSH and DWBSH produced were tested for their ACE inhibitory activity in relation to the hydrolysis time and degree of hydrolysis (DH). Maximum ACE inhibitory activity, both for UWBSH and DWBSH, were observed during 3 to 5 h of hydrolysis. Both, UWBSH (DH 91.84 %), and DWSBH (DH 18.72 %), produced by Papain at 5 h hydrolysis, exhibited exceptionally high ACE inhibitory activity with IC 50 value 0.064 and 0.249 mgmL −1 , respectively. Besides, papain-produced UWBSH and DWBSH were further fractionated into three fractions based on molecular weight (UWBSH-I, <10 kDa; UWBSH-II, <5 kDa; UWBSH-III, <2 kDa) and (DWBSH-I, <10 kDa; DWBSH-II, <5 kDa; DWBSH-III, <2 kDa). UWBSH-III revealed the highest ACE inhibitory activity (IC 50 0.003 mgmL . The results of the present investigation revealed that winged bean seed hydrolysates can be explored as a potential source of ACE inhibitory peptides suggesting their uses for physiological benefits as well as for other functional food applications.

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“…Some reported a high superoxide scavenging activity, whereas others found that captopril removed superoxide inefficiently. Chopra et al [5], using the technique described by Misra and Fridovich [15], demonstrated that captopril specifically scavenges O 2 -. On the other hand, Winterbourn & Metodiewa [16] as well as Kukreja et al [17], using a number of superoxide-generating systems such as xanthine-xanthine oxidase, phorbol myristate acetate-activated neutrophils, auto-oxidizing dihydroxyfumarate, and auto-oxidation of epinephrine to adrenochrome, asserted that captopril does not scavenge superoxide anion.…”

Section: Discussionmentioning

confidence: 99%

“…Much of it is carried as adsorbed captopril or as disulphydes with endogenous sulphydril-containing compounds such as glutathione and plasma proteins [4]. In this way, it can serve as the depot of the drug and could function as recyclable antioxidant agent [5].…”

Section: Introductionmentioning

confidence: 99%