Características clínicas de pacientes internados en el Hospital de Apoyo de Iquitos "César Garayar García" durante la epidemia de dengue, enero-febrero de 2011

Solórzano, Víctor Fiestas; Maldonado, Moisés Sihuincha; Toscano, Fernando Donaires; Velazco, Salomón Durand; M, María García; Mamani, Enrique; Pretell, Juan Gómez de la Torre

doi:10.1590/s1726-46342011000100012

Cited by 6 publications

(8 citation statements)

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“…DENV-2 predominated in 2011 (41% of all dengue cases analyzed) [36] and cocirculated mainly with DENV-1 [40, 41]. The highest incidence of DENV-4 occurred between 2006 and 2011, with a 53% overall seroconversion to DENV-4 among 2,997 participants of a cohort study during this period [42].…”

Section: Resultsmentioning

confidence: 99%

“…Other studies found that the risk for severe dengue was increased in patients under the age of 15 years, those with a history of dengue [35], and those needing repeated treatment for recurrent dengue symptoms [44], demonstrating that dengue was more common and generally more severe in young people [36]. …”

Section: Resultsmentioning

confidence: 99%

“…While dengue affects all age groups, available data on burden or severity of dengue by age group in Latin America and English-speaking and Hispanic Caribbean Islands are inconsistent, with some studies suggesting a greater burden or severity of disease among children [25, 35, 36, 44] and others suggesting the burden or severity of disease to be the same or higher among older children (aged ≥ 15 years) and adults [37, 57]. In Southeast Asia, where dengue has been circulating for much longer, there is evidence of an increase in the incidence of dengue towards older age groups [90] and that this age shift has led to dengue primarily affecting the adult population in some countries [91].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Torres

Orduña²,

Piña-Pozas

et al. 2017

Journal of Tropical Medicine

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Dengue, an important mosquito-borne virus transmitted mainly by Aedes aegypti, is a major public health issue in Latin America and the Caribbean. National epidemiological surveillance systems, usually based on passive detection of symptomatic cases, while underestimating the true burden of dengue disease, can provide valuable insight into disease trends and excess reporting and potential outbreaks. We carried out a systematic review of the literature to characterize the recent epidemiology of dengue disease in Latin America and the English-speaking and Hispanic Caribbean Islands. We identified 530 articles, 60 of which met criteria for inclusion. In general, dengue seropositivity across the region was high and increased with age. All four virus serotypes were reported to circulate in the region. These observations varied considerably between and within countries and over time, potentially due to climatic factors (temperature, rainfall, and relative humidity) and their effect on mosquito densities and differences in socioeconomic factors. This review provides important insight into the major epidemiological characteristics of dengue in distinct regions of Latin America and the Caribbean, allowing gaps in current knowledge and future research needs to be identified.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Torres

Orduña²,

Piña-Pozas

et al. 2017

Journal of Tropical Medicine

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“…This was reported as total number of days and/or average length of hospital stay in days, rather than as an association between length of stay and health outcomes [ 11 , 69 , 103 ]. Some documents described a rapid occurrence of death (at arrival or within the first 24 h) [ 30 , 32 , 40 , 65 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

Why are people with dengue dying? A scoping review of determinants for dengue mortality

Hernández²,

et al. 2015

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BackgroundDengue is a viral disease whose clinical spectrum ranges from unapparent to severe forms and fatal outcomes. Although dengue death is 99 % avoidable, every year around 20,000 deaths are estimated to occur in more than 100 countries. We consider that, along with biological factors, social determinants of health (SDHs) are related to dengue deaths as well.MethodsA scoping review was conducted to explore what has been written about the role of SDHs in dengue mortality. The inclusion criteria were that documents (grey or peer-reviewed) had to include information about dengue fatal cases in humans and be published between 1997 and 2013 and written in English, Spanish, Portuguese or French. The search was conducted using a set of key words related to dengue mortality in several electronic databases: PubMed, LILACS, COCHRANE, Scielo, Science Direct, WHOLIS, OpenGrey, OpenSingle and Google Scholar. Information on SDHs was categorized under individual, social and environmental, and health systems dimensions. A summative content analysis using QDA Miner was conducted to assess the frequency of information on SDHs and its contextual meaning in the reviewed literature. The role of each SDH in dengue mortality was assessed using content analysis results.ResultsFrom a total of 971 documents retrieved, 78 met the criteria. Those documents were published in the Americas region (50.0 %), Asia (38.4 %), Europe (9.0 %) and Africa (2.6 %). The described SDHs related to dengue deaths included, in the individual dimension: age, ethnicity, education, type of infection and immunological status; and in the social dimension: poverty and care-seeking behavior. The health systems dimension included access, opportunity, and quality of care, as well as health staff knowledge. Ethnicity was considered a determinant that depends on cultural and socioeconomic conditions.ConclusionsAlong with biological factors, there are several SDHs related to dengue mortality. However, only a few of these have been systematically analyzed, suggesting the need for more studies on this subject to inform the design and implementation of sustainable interventions to decrease dengue mortality. These findings nevertheless provide a better understanding of the non-biological factors involved in dengue mortality.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-015-1058-x) contains supplementary material, which is available to authorized users.

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“…Algunos estudios han informado resultado de la trombocitopenia y de la pérdida de plasma (26,27), y que las células intersticiales de la médula renal están implicadas en la regulación de la presión sanguínea mediante la secreción de una hormona con actividad antihipertensiva (28); sin embargo, no se sabe si existe o no una relación entre la infección por el virus del dengue y la disfunción de la médula renal en la regulación de la presión sanguínea.…”

Section: Discussionunclassified

Detección de antígenos del virus dengue en tejidos post mortem

et al. 2014

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El panorama epidemiológico del dengue ha empeorado durante la última década. Las dificultades para prevenir su transmisión, así como la ausencia de una vacuna o tratamiento específico, lo convierten en un riesgo que desafía las medidas de salud pública y desborda la capacidad de los centros de salud y los sistemas de investigación a muchos niveles. Actualmente, la mayoría de los estudios sobre la patogenia de la infección centran su atención en la respuesta inmunitaria de las células T casi exclusivamente en infecciones secundarias y están dirigidos a identificar los mecanismos implicados en el desarrollo de la permeabilidad vascular y de los eventos hemorrágicos que lo acompañan. En este reporte se describe el caso de una menor de 45 días de edad con signos clínicos de dengue grave, cuyo diagnóstico se confirmó por reacción en cadena de la polimerasa de transcripción inversa en muestras de tejido post mórtem y por herramientas de apoyo diagnóstico de inmunohistoquímica, las cuales detectaron antígenos virales en todos los órganos obtenidos en la necropsia. Este caso subraya la importancia del estudio de las infecciones primarias asociadas a dengue grave, particularmente en niños, en quienes es más probable el desarrollo de la forma grave de la enfermedad sin una infección previa, y, además, pone de relieve la importancia de un diagnóstico que no se limite a las muestras de tejido hepático en el estudio de la patogenia de la infección viral.Palabras clave: dengue, antígenos, inmunohistoquímica. doi: http://dx.doi.org/10.7705/biomedica.v34i4.2169 Detection of dengue virus antigen in post-mortem tissuesThe epidemiological situation of dengue has worsened over the last decade. The difficulties in preventing its transmission and the absence of a vaccine or specific treatment have made dengue a serious risk to public health, health centers and research systems at different levels. Currently, most studies on the pathogenesis of dengue infection focus on the T-cell immune response almost exclusively in secondary infections and are aimed at identifying the mechanisms involved in the development of vascular permeability and bleeding events that accompany the infection. This report describes the case of a baby girl less than 45 days of age with clinical signs of severe dengue, whose diagnosis was confirmed by reverse transcription polymerase chain reaction in postmortem tissue samples and by the ancillary diagnostic use of immunohistochemistry, which detected viral antigens in all organs obtained at autopsy. This case highlights the importance of studying primary infections associated with severe dengue, particularly in children, who are more likely to develop the severe form of the disease without previous infection, and it further stresses the importance of a diagnosis that should not be based solely on the examination of liver tissue samples when studying the pathogenesis of the viral infection.

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Características clínicas de pacientes internados en el Hospital de Apoyo de Iquitos "César Garayar García" durante la epidemia de dengue, enero-febrero de 2011

Cited by 6 publications

References 6 publications

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Why are people with dengue dying? A scoping review of determinants for dengue mortality

Detección de antígenos del virus dengue en tejidos post mortem

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