Características clínicas y epidemiológicas de pacientes con paracoccidioidomicosis diagnosticados en un hospital de Resistencia, Chaco

Abstract

In order to describe the clinical and epidemiological characteristics of paracoccidioidomycosis, a descriptive study of all the cases diagnosed by the Clinical Microbiology Service at Dr. Julio C. Perrando hospital in the city of Resistencia (Chaco Province, Argentina) was conducted. Between 2011 and 2014, 46 cases were detected. In the period 2013-2014, an almost 4-fold increase in the incidence rate was detected. The chronic form of the disease was predominant with an average age of 53 years. Serological tests in 39 out of 46 patients were performed. In 15 of 39 patients, serological tests were the only diagnostic tool while in 4 patients with a microbiological diagnosis serological tests were non-reactive. In patients from endemic areas with non-specific infectious syndrome it is important to include paracoccidioidomycosis in the differential diagnosis and to apply all available diagnostic tools to reach a timely diagnosis and to reduce the long-term sequelae and their socio-economic impact.

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

“…About demographic features, 80.67% of patients were males in a 4:1 ratio in comparison with female affection, as previously reported in other endemic countries such as Brazil (93.4%), Colombia (80%) and Argentina (70%); in Brazil, there is a wide range of male-female ratio reported from 3:1 to 10:1 according to the population studied. 31 , 32 , 33 , 34 In Venezuela, highly endemic areas such as Miranda can have a higher male-female proportion. Another study cohort with Venezuelan patients reports a similar male-female ratio 6,5:1 in the studied population.…”

Updates in Paracoccidioides Biology and Genetic Advances in Fungus Manipulation

“…The disease is widely distributed in Latin American countries, such as Brazil [4], Argentina [5], Uruguay [6], Paraguay [7], Peru [8], Ecuador [9], Colombia [10], Venezuela [11], and Mexico [12]. However, there are reports of imported cases in such countries as Japan [13], the Netherlands [14], Germany [15], and Austria [16] (Figure 1).…”

Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil

“…Additionally, differences in virulence between species [ 69 , 70 ] and the presence of distinct genetic profiles with variable capacity to infect mice have also been reported [ 71 ]. However, the correlation between clinical isolates and the geographic origin of patients must be interpreted with caution, as these isolates may have been acquired in regions different from those where the patient originated or was diagnosed with PCM [ 72 ].…”