Características Morfocuantitativas de la Glándula Submandibular de Ratón (Mus musculus)

Ocampo, Juan; Vásquez, Bélgica; Sandoval, Cristian; Navarrete, Javiera; Haidar, Ziyad S.; Olate, Sérgio

doi:10.4067/s0717-95022020000300570

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Technology Promise in Translational Tissue Engineering and NanoMedicinethe interplay between tissue engineering, regenerative medicine, biomaterials, bionanotechnology and nanomedicine continues to be the hallmark of current scientific research World-wide, promising to change every aspect of human life via creating revolutionary materials of biological origin for use in the diagnosis and treatment of devastating human diseases, a multi-disciplinary approach to innovative and translational solutions, suitable for scale-up, safe, efficacious and cost-effective routine clinical use [137][138][139]. Whether conventional small-molecule agents or emerging protein and/or peptide-based macromolecular biopharmaceutics, therapeutic effect is of vital significance.…”

Section: Wnt/β-catenin Pathway: Radio-protective Role and Effect In Rt-induced Salivary Gland Damagementioning

confidence: 99%

Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies

Haidar¹

2021

Biomechanics and Functional Tissue Engineering

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Saliva has a critical role in the maintenance of oral, dental and general health and well-being. Alteration(s) in the amount/quantity and/or quality of secreted saliva may induce the development of several oro-dental variations, thereby negatively-impacting overall quality of life. Diverse factors may affect the process of saliva production and quantity/quality of secretion, including medications, systemic or local pathologies and/or reversible/irreversible damage. Indeed, chemo- and/or radio-therapy, particularly, in cases of head and neck cancer, for example, are well-documented to induce serious damage and dysfunction to the radio-sensitive salivary gland tissue, resulting in hypo-salivation, xerostomia (dry mouth) as well as numerous other adverse intra−/extra-oral, medical and quality-of-life issues. Although a single governing mechanism of radiation-induced salivary gland tissue damage and dysfunction has not been yet elucidated, the potential for a synergy in radio-protection (mainly, and possible -reparation) via a combinatorial approach of mechanistically distinct strategies, has been suggested and explored over the years. This is, undoubtfully, in parallel to the ongoing efforts in improving the precision, safety and efficacy of radiotherapy protocols/outcomes, as well as in developing new technological and pharmaceutical alternatives, topics covered in this chapter.

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Section: Wnt/β-catenin Pathway: Radio-protective Role and Effect In Rt-induced Salivary Gland Damagementioning

confidence: 99%

Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies

Haidar¹

2021

Biomechanics and Functional Tissue Engineering

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Morphology, glicohistochemistry and immunolocalization of Aquaporin 5 in the mandibular gland of the giant anteater (Myrmecophaga tridactyla)

Schimming,

Bordin,

Sasahara

et al. 2025

Annals of Anatomy - Anatomischer Anzeiger

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Radiation-induced salivary gland damage/dysfunction in head and neck cancer: Nano-bioengineering strategies and artificial intelligence for prevention, therapy and reparation

Haidar¹

2022

J Radiol Oncol

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Saliva is produced by and secreted from salivary glands. It is an extra-cellular fluid, 98% water, plus electrolytes, mucus, white blood cells, epithelial cells, enzymes, and anti-microbial agents. Saliva serves a critical role in the maintenance of oral, dental, and general health and well-being. Hence, alteration(s) in the amount/quantity and/or quality of secreted saliva may induce the development of several oro-dental variations, thereby the negatively-impacting overall quality of life. Diverse factors may affect the process of saliva production and quantity/quality of secretion, including medications, systemic or local pathologies and/or reversible/irreversible damage. Herein, chemo- and/or radio-therapy, particularly, in cases of head and neck cancer, for example, are well-documented to induce serious damage and dysfunction to the radio-sensitive salivary gland tissue, resulting in hypo-salivation, xerostomia (dry mouth) as well as numerous other adverse Intra-/extra-oral, medical and quality-of-life issues. Indeed, radio-therapy inevitably causes damage to the normal head and neck tissues including nerve structures (brain stem, spinal cord, and brachial plexus), mucous membranes, and swallowing muscles. Current commercially-available remedies as well as therapeutic interventions provide only temporary symptom relief, hence, do not address irreversible glandular damage. Further, despite salivary gland-sparing techniques and modified dosing strategies, long-term hypo-function remains a significant problem. Although a single governing mechanism of radiation-induced salivary gland tissue damage and dysfunction has not been yet elucidated, the potential for synergy in radio-protection (mainly, and possibly -reparation) via a combinatorial approach of mechanistically distinct strategies, has been suggested and explored over the years. This is, undoubtfully, in parallel to the ongoing efforts in improving the precision, safety, delivery, and efficacy of clinical radiotherapy protocols/outcomes, and in designing, developing, evaluating and optimizing (for translation) new artificial intelligence, technological and bio-pharmaceutical alternatives, topics covered in this review.

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Características Morfocuantitativas de la Glándula Submandibular de Ratón (Mus musculus)

Cited by 3 publications

References 26 publications

Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies

Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies

Morphology, glicohistochemistry and immunolocalization of Aquaporin 5 in the mandibular gland of the giant anteater (Myrmecophaga tridactyla)

Radiation-induced salivary gland damage/dysfunction in head and neck cancer: Nano-bioengineering strategies and artificial intelligence for prevention, therapy and reparation

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