Caractéristiques épidémio-cliniques de l’hypertension artérielle résistante du sujet noir africain

Yaméogo, Nobila Valentin; Samadoulougou, A.K.; Kagambèga, L.J.; Millogo, Georges Rosario Christian; Yaméogo, Aimé Arsène; Kologo, Koudougou Jonas; Ilboudo, E.; Kaboré, Esther; Mandi, Germain; Kombassere, Karim; Toguyéni, B.J.Y.; Pignatelli, Salvatore; Simporé, J.; Zabsonré, Patrice

doi:10.1016/j.ancard.2014.01.002

Cited by 11 publications

(22 citation statements)

References 19 publications

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“… 13 26 27 At the end of the process, only five studies met the inclusion criteria and were thus retained for qualitative and quantitative analyses ( figure 1 ). 15 28–31 Agreement between reviewers was high (κ=0.88, p<0.001).…”

Section: Resultsmentioning

confidence: 97%

“…The prevalence of RH was 11.7% (95% CI 9.3% to 14.6%) in Cameroon, 4.9% (95% CI 3.4% to 7.1%) in Nigeria, 14.6% (95% CI 12.2% to 17.4%) in Burkina Faso, 14.3% (95% CI 7.9% to 24.6%) in Lesotho and 19.0% (95% CI 17.4% to 20.7%) in Algeria. 15 28–31 The I² statistic was 94.1% (p<0.001) and the estimation of between-study variance (τ²) was 0.234. Using a random-effects meta-analysis, the overall pooled prevalence was 12.1% (95% CI 8.0% to 17.7%; figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 summarises the characteristics of studies included in the review. The first study was conducted in Yaoundé (Cameroon, Central Africa) from January to December 1991, 28 the second in Ibadan (Nigeria, West Africa), 29 the third in Ouagadougou (Burkina Faso, West Africa) from 1 May 2010 to 31 May 2012, 15 the fourth in Maseru (Lesotho, Southern Africa) in April to May 2013, 30 and the last one in Blida (Algeria, North Africa) between June 2012 and June 2014. 31 This was a conference abstract, the full paper of which remains unpublished until now.…”

Section: Resultsmentioning

confidence: 99%

“…The study population comprised 565 patients in Cameroon, 566 in Nigeria, 692 in Burkina Faso, 70 in Lesotho and 2175 in Algeria, making a total of 4068 patients. 15 28–31 The male proportion of patients with RH ranged between 48.5% and 62.1% ( table 1 ). 15 28–30 The mean ages of participants across studies are presented in table 1 .…”

Section: Resultsmentioning

confidence: 99%

“… 15 28–31 The male proportion of patients with RH ranged between 48.5% and 62.1% ( table 1 ). 15 28–30 The mean ages of participants across studies are presented in table 1 .…”

Section: Resultsmentioning

confidence: 99%

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The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis

et al. 2016

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ObjectiveThe hypertension epidemic in Africa collectively with very low rates of blood pressure control may predict an incremented prevalence of resistant hypertension (RH) across the continent. The aim of this study was to determine the prevalence of RH and associated risk factors in Africa.Data sourcesWe conducted a comprehensive search of electronic databases (PubMed, EMBASE, Africa Wide Information and Africa Index Medicus) completed by manual search of articles, regardless of language or publication date.MethodsWe included studies which have reported the prevalence and/or risk factors for RH in Africa from inception to 19 May 2016. Forest plots were drawn to visualise the combined prevalence of RH and extent of statistical heterogeneity between studies.ResultsOut of 259 retrieved studies, only 5 from Cameroon, Nigeria, Burkina Faso, Lesotho and Algeria with a total population of 4 068 patients were finally included in this review. There was no study from the Eastern part of Africa. Though the definition of RH was not similar across studies, its prevalence was respectively 11.7%, 4.9%, 14.6%, 14.3% and 19.0%, with an overall pooled prevalence of 12.1% (95% CI 8.0% to 17.7%). Potential risk factors were: non-compliance to treatment, ageing, male sex, dyslipidaemia, metabolic syndrome, previous cardiovascular events, physical inactivity and stress, but not excessive salt intake, alcohol and coffee ingestions. Moreover, diabetes, smoking, obesity and renal insufficiency yielded discrepant results.ConclusionsThere is a huge dearth of research on the epidemiology of RH in Africa. Thereby, an extensive study of RH prevalence and risk factors is still largely warranted to curtail the high and continuously increasing burden of hypertension across Africa.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“… 15 28–31 The male proportion of patients with RH ranged between 48.5% and 62.1% ( table 1 ). 15 28–30 The mean ages of participants across studies are presented in table 1 .…”

Section: Resultsmentioning

confidence: 99%

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The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis

et al. 2016

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L’hypertension artérielle à Dakar : prévalence, connaissance, traitement et contrôle

Macia

Duboz

Guéye

2014

Bull. Soc. Pathol. Exot.

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The aim of this study was to determine prevalence, awareness, treatment, and control of hypertension, and its risk factors in Dakar. Six hundred people aged 20 and older, living in the city of Dakar were interviewed. This sample was constructed using the combined quota method in order to strive to representativeness of the target population. Prevalence of hypertension was 27.50%. Quarter of those suffering from high blood pressure were aware of their problem, and among the latter, 61% said they were on treatment. However, of these, only 32% had controlled arterial blood pressure, that is less than 6% of those suffering from hypertension. Two factors were associated with hypertension, awareness, and treatment: age and the frequency of doctor visits. These results indicate that hypertension already constitutes a major health concern in the Senegalese capital. Detection can be considerably improved given that only a quarter of the hypertensives are aware of this problem. Compliance with treatments also appears particularly problematic. Public health policies should be quickly set up to minimize the consequences of this emerging burden.

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Association of the genetic ancestry with resistant hypertension in the ReHOT (Resistant Hypertension Optimal Treatment) randomized study

Bueno

Pereira

Santos

et al. 2020

Sci Rep

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Resistant hypertension (RH) is defined as uncontrolled blood pressure despite treatment with three or more antihypertensive medications, including, if tolerated, a diuretic in adequate doses. it has been widely known that race is associated with blood pressure control. However, intense debate persists as to whether this is solely explained by unadjusted socioeconomical variables or genetic variation. in this scenario, the main aim was to evaluate the association between genetic ancestry and resistant hypertension in a large sample from a multicenter trial of stage ii hypertension, the ReHot study. Samples from 1,358 patients were analyzed, of which 167 were defined as resistant hypertensive. Genetic ancestry was defined using a panel of 192 polymorphic markers. The genetic ancestry was similar in resistant (52.0% European, 36.7% African and 11.3% Amerindian) and nonresistant hypertensive patients (54.0% European, 34.4% African and 11.6% Amerindian) (p > 0.05). However, we observed a statistically suggestive association of African ancestry with resistant hypertension in brown patient group. in conclusion, increased African genetic ancestry was not associated with RH in Brazilian patients from a prospective randomized hypertension clinical trial.likely to be black 8 . Some variables, such as advanced age, increased body mass index, male gender, genetic variants and others chronic diseases were also associated with RH or uncontrolled hypertension [28][29][30][31] .On the other hand, some studies, including the present study, did not find an association of self-reported race/ color with RH. A study with 9,361 hypertensive patients from the US, did not find differences in RH proportions according to race 32 . In addition, a meta-analysis, which analyzed the global prevalence of RH from data of 3.2 million patients, did not observe differences 33 . Some studies have observed genetic variants associated with risk for resistant hypertension 2,34,35 . However, to the best of our knowledge, studies of genetic ancestry and RH are not identified in the literature. Our hypothesis was that an increased proportion of African ancestry might be a risk factor for RH, in the overall group or even in subgroups among self-declared race/color, but this was not confirmed. However, in brown patient group, we identified a statistically suggestive association of African ancestry with resistant hypertension. This statistically suggestive association suggests that the criteria applied to segregate the race/color groups, according Brazilian Institute of Geography and Statistics, are possibly distorting the real distribution and, at least in part, leading a limitation for dividing into homogeneous groups. Thus, further investigations and new hypothesis should be tested to elucidate possible associations.The prevalence and incidence of RH will grow considerably because there is a large number of overweight/ obese individuals 36 . In addition, the cutoff blood pressure criteria for RH was reduced from 140/90 mmHg to < 130/80 mmHg 9 . Thus, prev...

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Caractéristiques épidémio-cliniques de l’hypertension artérielle résistante du sujet noir africain

Cited by 11 publications

References 19 publications

The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis

The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis

L’hypertension artérielle à Dakar : prévalence, connaissance, traitement et contrôle

Association of the genetic ancestry with resistant hypertension in the ReHOT (Resistant Hypertension Optimal Treatment) randomized study

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