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BackgroundThe aim of this study was to describe maternal and fetal outcomes after pregnancy complicated by peripartum cardiomyopathy (PPCM).MethodsWe included women that had subsequent pregnancy (SSP) after PPCM and assessed maternal prognosis and pregnancy outcomes, in-hospital up to one week after discharge. Clinical and echocardiographic data were collected comparing alive and deceased women. Factors associated with pregnancy outcomes were assessed.ResultsTwenty-nine patients were included, with a mean age of 26.7 ± 4.6 years and a mean gravidity number of 2.3 ± 0.5 of. At the last medical control before subsequent pregnancy, there was no congestive heart failure, the mean left ventricular diastolic diameter (LVDD) was 53 ± 4 mm and the left ventricular ejection fraction (LVEF) was ≥50% in 13 cases (44.8%).Maternal outcomes were marked by 14 deaths (48.3%). Among the factors tested in univariate analysis, LVEF at admission had an excellent receiver-operating characteristic (ROC) curve to predict maternal mortality (AUC = 0.95; 95% CI 0.87–1, p < 0.001), with a cut off value of < 40% (sensitivity = 93% and specificity = 87%). Concerning fetal outcomes, baseline LVEF had the best area under the curve (AUC) to predict abortion or prematurity among all variables (AUC = 0.75; 95% CI 0.58–092, p = 0.003), with a cut-off value of < 50% (sensitivity = 79%, specificity = 67%).ConclusionsSSP outcomes are still severe in our practice. Maternal mortality remains high and is linked to ventricular systolic function at admission (due to pregnancy), while fetal outcomes are linked to baseline LVEF before pregnancy.

IntroductionMorbidity and mortality from diabetes are compounded by associated cardiovascular risk factors. For this reason, taking care of these risk factors is a public health goal.In this study we evaluated the level of control of cardiovascular risk factors in black Africans with type 2 diabetes in Senegal.MethodsBetween March 2007 and July 2008, we recruited type 2 diabetes patients from outpatient care in a specialised hospital in Senegal. Data were collected on a survey form designed for this purpose. An electrocardiogram and laboratory examinations were also performed. The level of control of diabetes and associated cardiovascular risk factors were assessed, as recommended by the American Diabetes Association (ADA).ResultsA total of 318 type 2 diabetes subjects (237 women) were recruited. The average age was 58.2 ± 9.2 years (40–85). The mean duration of diabetes was 6.9 ± 5.9 years. The average glycaemic level was 1.4 ± 0.5 g/l and glycated haemoglobin was 7.6 ± 3.2%. The average length of patient follow up was 6.7 ± 6.1 years with a single annual consultation; 63.2% of the patients were on an insulin + biguanide combination, with good diabetes control (HbA1c < 7%) in 25% of cases. Antihypertensive drugs were prescribed in 28.1% of hypertensive patients. More than half (51.9%) of these hypertensive patients were treated with angiotensin converting enzyme inhibitors. Their blood pressure was well controlled (< 130/85 mmHg) in 5.4% of the hypertensive patients (10/185). The low-density lipoprotein (LDL) cholesterol goal was achieved in 18.5% of cases (5/27).ConclusionThis study shows that the prevalence of cardiovascular risk factors is higher among black Africans suffering from type 2 diabetes. The control of these factors was not optimal in our study.

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