Caracterización Clínica y Epidemiológica de Dengue Hemorrágico en Neiva, Colombia, 2004

Salgado, Doris M.; Rodríguez, Jairo; Garzón, Marisol; Cifuentes, Gerson; Ibarra, Milton; Vega, Martha Rocío; Castro, Dolly

doi:10.1590/s0124-00642007000100006

Cited by 14 publications

(15 citation statements)

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“…We did not, however, observe a correlation between thrombocyte numbers and bleeding, as was also found in a study conducted in Brazil [13], since only one patient (patient #14) had thrombocytopenia (73,000/μl) upon presentation, while all of the patients who subsequently developed SDD each displayed conjunctival injection, petechia and veni-puncture bleeding. In another study, conducted in southern Colombia (Neiva), there was a correlation between thrombocytopenia (< 20,000/μl) on the day of hospitalization and the subsequent development of shock (DSS) [33]. However, we observed thrombocyte numbers of 152,000 and 267,000 in patient #9 and #28 on the day of presentation (day 2 and 3 respectively), which dropped to 49,000 and 23,000 on day 4 and 5 respectively after the onset of fever when they developed shock (DSS: DHF III).…”

Section: Discussionmentioning

confidence: 99%

Simple Prognostic Criteria Can Definitively Identify Patients Who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses

Falconar

Romero-Vivas

2012

J Clin Med Res

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BackgroundSevere dengue disease (SDD) (DHF/DSS: dengue hemorrhagic fever/dengue shock syndrome) results from either primary or secondary dengue virus (DENV) infections, which occur 4 - 6 days after the onset of fever. As yet, there are no definitive clinical or hematological criteria that can specifically identify SDD patients during the early acute febrile-phase of disease (day 0 - 3: < 72 hours). This study was performed during a SDD (DHF/DSS) epidemic to: 1) identify the DENV serotypes that caused SDD during primary or secondary DENV infections; 2) identify simple clinical and hematological criteria that could significantly discriminate between patients who subsequently developed SDD versus non-SDD (N-SDD), or had a non-DENV fever of unknown origin (FUO) during day 0 - 3 of fever; 3) assess whether DENV serotype co-infections resulted in SDD.MethodsFirst serum samples, with clinical and hematological criteria, were collected from 100 patients during the early acute febrile-phase (day 0 - 3: < 72 hours), assessed for DENV or FUO infections by IgM- and IgG-capture ELISAs on paired serum samples and by DENV isolations, and subsequently graded as SDD, N-SDD or FUO patients.ResultsIn this study: 1) Thirty-three patients had DENV infections, predominantly secondary DENV-2 infections, including each SDD (DHF/DSS) case; 2) Secondary DENV-2/-3 and DENV-2/-4 serotype co-infections however resulted in N-SDD; 3) Each patient who subsequently developed SDD, but none of the others, displayed three clinical criteria: abdominal pain, conjunctival injection and veni-puncture bleeding, therefore each of these criteria provided definitively significant prognostic (P < 0.001) values; 4) Petechia, positive tourniquet tests and hepatomegaly, and neutrophilia or leukopenia also significantly identified those who: a) subsequently developed SDD versus N-SDD, or had a FUO; b) subsequently developed SDD versus N-SDD; c) subsequently developed N-SDD versus FUOs, respectively.ConclusionsThis is the first report of simple definitively prognostic criteria for SDD patients, including the first assessment and confirmation of conjunctival injection. The three definitive clinical criteria used alone, or supported by the other four criteria, could be essential for specifically identifying those patients needing prompt hospital-based therapies to lessen or avert SDD, without unnecessary hospitalization of the other patients.KeywordsDengue virus; Severe dengue; Dengue fever; Diagnostic; Criteria; Hemorrhage; Shock

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Section: Discussionmentioning

confidence: 99%

Simple Prognostic Criteria Can Definitively Identify Patients Who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses

Falconar

Romero-Vivas

2012

J Clin Med Res

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“…Os sangramentos mais frequentemente observados foram os relacionados ao comprometimento da primeira fase da hemostasia, que propicia sangramentos preferencialmente cutâno-mucosos. Resultados similares foram relatados em estudo realizado em 105 pacientes pediátricos com dengue, em Neiva, Colômbia, no qual se verificou a ocorrência de manifestações hemorrágicas de pele e mucosas em 75% dos pacientes 10 . Não houve diferença quanto ao tipo de sangramento no DC e na FHD, sugerindo que ambos os grupos apresentaram como principal defeito de hemostasia o comprometimento de primeira fase.…”

Section: Discussionunclassified

Alterações hematológicas em pacientes com dengue

Oliveira¹,

Pontes

Cunha

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Dengue é uma doença negligenciada de alta morbidade e mortalidade em crianças e adultos, ocorrendo principalmente em regiões tropicais e subtropicais. O objetivo desse trabalho foi avaliar as alterações hematológicas de pacientes com quadro clínico de dengue. Foram estudados 543 prontuários de atendimentos referentes à epidemia pelo vírus tipo 3, ocorrida no ano de 2007, em Campo Grande, Mato Grosso do Sul. Houve predomínio de casos de dengue clássico (90,2%), com quadro clínico leve sem complicações. As principais alterações hematológicas observadas foram a leucopenia (68,3%), plaquetopenia (66,5%), linfocitopenia (67,2%) e presença de linfócitos atípicos (67%). A febre hemorrágica do dengue apresentou plaquetopenia mais prolongada e maior número de linfócitos atípicos, as demais alterações hematológicas apresentaram evolução diária semelhante às encontradas no dengue clássico. As alterações hematológicas observadas no dengue apresentaram-se de acordo com a evolução clínica e gravidade da doença.

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“…La frecuencia de compromiso de órganos encontrada fue de 18.1%, similar a la descrita en la serie de Salgado et al (7), constituyéndose en la segunda causa de DG, después del choque. La miocarditis, con 14 casos, ocupó el primer lugar dentro de las causas de organopatía, resaltando la importancia de su diagnóstico en dengue (7,14,15).…”

Section: Discussionunclassified

“…Estas manifestaciones contribuyen con la mortalidad y pueden ocurrir aún en ausencia de fuga vascular o choque (5,6), como ha sido mostrado en otro reporte realizado en Neiva, Colombia (7).…”

Section: Introductionunclassified

Análisis descriptivo del compromiso de órganos en niños con dengue grave en Neiva, Colombia

et al. 2017

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Análisis descriptivo del compromiso de órganos en niños con dengue grave en Neiva, Colombia Objective: To describe the affectation caused by dengue in organs such as the myocardium, the liver and the central nervous system (CNS) in children from Neiva, Colombia. Results: Out of 930 children, 105 were classified as severe dengue (SD) and, of these, 19 had affected organs. The myocardium was the most compromised organ (14 cases), followed by the liver (4 cases) and the CNS (1 case). Materials and methods: Conclusion:Clinical involvement of the myocardium, liver or CNS was observed in 18% of the cases of children with SD. A timely diagnosis and treatment of this pathology in children is necessary.

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Caracterización Clínica y Epidemiológica de Dengue Hemorrágico en Neiva, Colombia, 2004

Abstract: The clinical and epidemiological characteristics observed in this cohort evidenced differences in age, gender and organs affected compared to data described in the literature; there was a high incidence of myocarditis.

Cited by 14 publications

References 11 publications

Simple Prognostic Criteria Can Definitively Identify Patients Who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses

Simple Prognostic Criteria Can Definitively Identify Patients Who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses

Alterações hematológicas em pacientes com dengue

Análisis descriptivo del compromiso de órganos en niños con dengue grave en Neiva, Colombia

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