Carbamylated Hemoglobin as an Indicator of Hemodialysis Adequacy and Complications

Abdelwhab, Saeed; Ahmed, Hayam

doi:10.1007/s00596-008-0037-2

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…There are some limitations in this study that require comment. First, the average molecular weight of Hb could be slightly increased in HD patients due to the presence of glycated and carbamylated Hb 42–45 . This may result in a minor (−0.5%) underestimation of the effect of HD on PV.…”

Section: Discussionmentioning

confidence: 99%

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Intravascular albumin loss is strongly associated with plasma volume withdrawal in dialysis patients

Haider

Díaz-Cañestro

Pentz

et al. 2020

Hemodialysis International

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Introduction Low circulating albumin closely predicts mortality in end‐stage renal disease (ESRD) patients. The cause(s) of hypoalbuminemia (hALB) in ESRD patients remains to be elucidated. The aim of the present study was to determine the role of plasma volume (PV) withdrawal in the reduction of total circulating albumin and essential blood solutes induced by hemodialysis (HD). Methods PV determined with high‐precision automated carbon monoxide‐rebreathing, total circulating as well as concentration of plasma albumin and electrolytes were assessed prior to and after 4‐hour HD in 10 ESRD patients. Findings Baseline PV ranged from 3.5 to 6.2 l. After HD, PV was decreased by 689 ± 566 mL (−16%) (P = 0.004). Total circulating albumin was largely reduced after HD (170.8 ± 35.1 vs. 146.1 ± 48.9 g, P = 0.008), while albumin concentration was unaltered. According to a strong linear relationship (r = 0.91, P < 0.001), one‐third of total circulating albumin is lost from the intravascular compartment for every liter of PV removed. Similar results were found regarding Na+ and Ca2+ electrolytes. Discussion Total circulating albumin, but not albumin concentration, is substantially reduced by HD in proportion to the amount of PV removed from the circulation. This study highlights the potential contributing role of PV withdrawal to hALB in ESRD patients.

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Section: Discussionmentioning

confidence: 99%

“…First, the average molecular weight of Hb could be slightly increased in HD patients due to the presence of glycated and carbamylated Hb. [42][43][44][45] This may result in a minor (−0.5%) underestimation of the effect of HD on PV. Likewise, the CO affinity of Hb might be altered by potential alterations in blood pH.…”

Section: Discussionmentioning

confidence: 99%

Intravascular albumin loss is strongly associated with plasma volume withdrawal in dialysis patients

Haider

Díaz-Cañestro

Pentz

et al. 2020

Hemodialysis International

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Respiratory Function of Hemoglobin: From Origin to Human Physiology and Pathophysiology

Hsia

2021

Cardiopulmonary Monitoring

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Carbamylated Hemoglobin as an Indicator of Hemodialysis Adequacy and Complications

Cited by 2 publications

References 23 publications

Intravascular albumin loss is strongly associated with plasma volume withdrawal in dialysis patients

Intravascular albumin loss is strongly associated with plasma volume withdrawal in dialysis patients

Respiratory Function of Hemoglobin: From Origin to Human Physiology and Pathophysiology

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