Carbapenem resistance in the food supply chain

Huang, En; Xu, Yang; Leighton, Elizabeth; Li, Xinhui

doi:10.1016/j.jfp.2023.100108

Cited by 8 publications

(3 citation statements)

References 120 publications

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“…To date, bla NDM -positive Enterobacterales have been identified in various sources, including food animals, pets, human beings, animal foods, vegetables, and the environment (Zhai et al, 2020;Huang et al, 2023;Ma et al, 2023). However, there are few reports of NDM-producing bacteria in egg sources, except for one study, which reported the presence of bla NDM -positive Salmonella enterica in eggs from Iraq (Kanaan et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Occurrence and characterization of NDM-5-producing Escherichia coli from retail eggs

Liu,

Li,

Yue

et al. 2023

Front. Microbiol.

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The New Delhi Metallo-β-lactamase (NDM) producing Enterobacterales has been detected from diverse sources but has rarely been reported in retail eggs. In this study, 144 eggshell and 96 egg content samples were collected in 2022 from Guangdong province and were screened for NDM-producing strains. Four Escherichia coli strains (ST3014, ST10, ST1485, and ST14747) recovered from two (1.39%, 2 of 144) eggshells and two (2.08%, 2 of 96) egg content samples were identified as blaNDM−5-positive strains. Oxford Nanopore MinION sequencing and conjugation assays revealed that the blaNDM−5 gene was carried by IncX3 (n = 1), IncI1 (n = 1), and IncHI2 (n = 2). The IncI1-plasmid-carrying blaNDM−5 displayed high homology with one plasmid pEC6563-NDM5 from the human clinic, while the IncHI2 plasmid harboring blaNDM−5 shared highly similar structures with plasmids of animal origin. To the best of our knowledge, this is the first report on the identification of blaNDM−5-positive bacteria in retail eggs. NDM-producing E. coli could be transmitted to humans by the consumption of eggs or direct contact, which could pose a potential threat to human health.

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Section: Discussionmentioning

confidence: 99%

Occurrence and characterization of NDM-5-producing Escherichia coli from retail eggs

Liu,

Li,

Yue

et al. 2023

Front. Microbiol.

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“…Studies conducted in Faisalabad, Pakistan, have identified VIM (Verona integron‐encoded metallo‐β‐lactamase) and GES (Guiana extended‐spectrum β‐lactamase) as two carbapenemase genes in S . Typhi (Ain et al., 2022; Huang et al., 2023).…”

Section: Mechanisms Of Drug Resistance In Salmonellamentioning

confidence: 99%

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

Chowdhury,

Mukherjee,

Chatterjee

et al. 2023

Molecular Microbiology

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Salmonella Typhi, the invasive serovar of S. enterica subspecies enterica, causes typhoid fever in healthy human hosts. The emergence of antibiotic‐resistant strains has consistently challenged the successful treatment of typhoid fever with conventional antibiotics. Antimicrobial resistance (AMR) in Salmonella is acquired either by mutations in the genomic DNA or by acquiring extrachromosomal DNA via horizontal gene transfer. In addition, Salmonella can form a subpopulation of antibiotic persistent (AP) cells that can survive at high concentrations of antibiotics. These have reduced the effectiveness of the first and second lines of antibiotics used to treat Salmonella infection. The recurrent and chronic carriage of S. Typhi in human hosts further complicates the treatment process, as a remarkable shift in the immune response from pro‐inflammatory Th1 to anti‐inflammatory Th2 is observed. Recent studies have also highlighted the overlap between AP, persistent infection (PI) and AMR. These incidents have revealed several areas of research. In this review, we have put forward a timeline for the evolution of antibiotic resistance in Salmonella and discussed the different mechanisms of the same availed by the pathogen at the genotypic and phenotypic levels. Further, we have presented a detailed discussion on Salmonella antibiotic persistence (AP), PI, the host and bacterial virulence factors that can influence PI, and how both AP and PI can lead to AMR.

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“…In addition, the overuse of drugs observed in recent years has certainly contributed to the whole reality. The prevalence of antibiotics in the environment, e.g., use in veterinary medicine, agriculture, and animal nutrition, as well as unjustified use and inappropriate dosage, i.e., in viral infections and bacterial carriage, has also become an additional factor [34]. This has led to the emerging resistance of bacterial strains to drugs of last resort, i.e., carbapenems, glycopeptides, or colistin [35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

Pacyga,

Topola

et al. 2024

IJMS

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The rising prevalence of drug-resistant bacteria underscores the need to search for innovative and nature-based solutions. One of the approaches may be the use of plants that constitute a rich source of miscellaneous compounds with a wide range of biological properties. This review explores the antimicrobial activity of seven bioactives and their possible molecular mechanisms of action. Special attention was focused on the antibacterial properties of berberine, catechin, chelerythrine, cinnamaldehyde, ellagic acid, proanthocyanidin, and sanguinarine against Staphylococcus aureus, Enterococcus spp., Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Serratia marcescens and Pseudomonas aeruginosa. The growing interest in novel therapeutic strategies based on new plant-derived formulations was confirmed by the growing number of articles. Natural products are one of the most promising and intensively examined agents to combat the consequences of the overuse and misuse of classical antibiotics.

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Carbapenem resistance in the food supply chain

Cited by 8 publications

References 120 publications

Occurrence and characterization of NDM-5-producing Escherichia coli from retail eggs

Occurrence and characterization of NDM-5-producing Escherichia coli from retail eggs

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

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