Carbapenem-resistant Klebsiella pneumoniae harbouring blaKPC-3 and blaVIM-2 from central Italy

Perilli, Mariagrazia; Bottoni, Carlo; Grimaldi, Alessandro; Segatore, Bernardetta; Celenza, Giuseppe; Mariani, Maurizio; Bellio, Pierangelo; Frascaria, Patrizia; Amicosante, Gianfranco

doi:10.1016/j.diagmicrobio.2012.10.008

Cited by 23 publications

(17 citation statements)

References 16 publications

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“…In K. pneumonia , many of the VIM‐1/4 genes are carried on plasmids with Inc group N, whereas those genes carried by E. coli are often IncFI/II . Isolates of K. pneumoniae carrying both bla VIM‐1 and bla KPC‐2 were reported initially from Greece and, later, from other countries including Italy, Germany, and Colombia …”

Section: Metallo‐beta Lactamases: Ndm and Vimmentioning

confidence: 99%

“…84 Isolates of K. pneumoniae carrying both bla VIM-1 and bla KPC-2 were reported initially from Greece and, later, from other countries including Italy, Germany, and Colombia. [85][86][87][88][89] VIM-producing K. pneumoniae isolates from the SMART surveillance program were typed and 63% were found to belong to ST-147. 90 Clonal spread of the VIM-carrying ST-147 strains with IncF and IncA/C plasmids was shown to occur within and between hospitals, and even between countries (Greece, Italy, and Scandinavia).…”

Section: Ndm-1mentioning

confidence: 99%

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Carbapenem‐resistant Enterobacteriaceae: biology, epidemiology, and management

Temkin

Adler

Lerner

et al. 2014

Annals of the New York Academy of Sciences

196

167

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Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.

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Section: Metallo‐beta Lactamases: Ndm and Vimmentioning

confidence: 99%

Section: Ndm-1mentioning

confidence: 99%

Carbapenem‐resistant Enterobacteriaceae: biology, epidemiology, and management

Temkin

Adler

Lerner

et al. 2014

Annals of the New York Academy of Sciences

196

167

View full text Add to dashboard Cite

show abstract

“…The identification of b-lactamase genes was performed by PCR [8]. The identification of b-lactamase genes was performed by PCR [8].…”

mentioning

confidence: 99%

In vivo multiclonal transfer of blaKPC-3 from Klebsiella pneumoniae to Escherichia coli in surgery patients

Gona

Barbera

Pasquariello

et al. 2014

Clinical Microbiology and Infection

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During active surveillance at the Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT, Palermo, Italy) with the CARBA screening medium, five pairs of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae and Escherichia coli strains were isolated in each of five colonized patients. In each patient, lateral gene transfer was demonstrated by comparing K. pneumoniae and E. coli strains, both possessing KPC-3, Tn4401a and pKpQIL-IT elements. The isolates were found to be multiclonal by multilocus sequence typing (sequence type (ST) 512 related to ST258, and ST307 belonging to a clonal complex different from the habitual sequence clone ST258 isolated in Italy) and pulsed-field gel electrophoresis. The results of our study highlight the easy transfer of KPC among Enterobacteriaceae colonizing the human intestine, and the active and careful surveillance required to identify and prevent the spread of these multidrug-resistant microorganisms.

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“…(tableau III). [3,5,6,7] Les carbapénèmases KPC appartenant à la classe A peuvent être plasmidique ou chromosomique [2]. Ils étaient identifiés pour la première fois à la côte Est des Etats Unis chez Klebsiellapneumoniae.…”

Section: Résultats:-unclassified

“…Klebsiellapneumoniae est l'entérobactérie la plus retrouvée exprimant cette résistance aux carbapénèmes [1,3,5,6,7,13]. L'explication de la diffusion préférentielle de ces gènes de carbapénèmases chez K. pneumoniae en milieu hospitalier n'est pas connue [1].…”

Section: Résultats:-unclassified