Carbendazim-induced androgen receptor expression antagonized by flutamide in male rats

Hsu, Yuan-Ming; Chang, Chiung-Wei; Chen, Min-Chen; Yuan, Chao-Yun; Chen, Jing-Huei; Ma, Jui-Ti; Ueng, Tzuu-Huei; Lu, Shui-Yuan

doi:10.38212/2224-6614.2198

Cited by 5 publications

(5 citation statements)

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“…[6] CBZ is commercially used as fungicide, pesticide [7] and industrially used as preservative in textile, leather, paper, paints and several other industries. [8][9][10] CBZ has been found in varying amounts (ranging from 0.003 to 156 µg/L) in surface water, groundwater, municipal waste-water, marine water, and even drinking water. [11][12][13][14] Human exposure to CBZ can occur via direct routes including oral, inhalation and dermal contact as well as indirect pathways such as ingestion of fungicide-treated cereals and fruits, drinking contaminated water, residential and occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

Carbendazim toxicity in different cell lines and mammalian tissues

Sharma

Maheshwari

Khan

et al. 2022

J Biochem & Molecular Tox

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The extensive production and use of harmful pesticides in agriculture to improve crop yield has raised concerns about their potential threat to living components of the environment. Pesticides cause serious environmental and health problems both to humans and animals. Carbendazim (CBZ) is a broad spectrum fungicide that is used to control or effectively kill pathogenic microorganisms. CBZ is a significant contaminant found in food, soil and water. It exerts immediate and delayed harmful effects on humans, invertebrates, aquatic animals and soil microbes when used extensively and repeatedly. CBZ is a teratogenic, mutagenic and aneugenic agent that imparts its toxicity by enhancing generation of reactive oxygen species generation. It elevates the oxidation of thiols, proteins and lipids and decreases the activities of antioxidant enzymes. CBZ is cytotoxic causing hematological abnormalities, mitotic spindle deformity, inhibits mitosis and alters cell cycle events which lead to apoptosis. CBZ is known to cause endocrine-disruption, embryo toxicity, infertility, hepatic dysfunction and has been reported to be one of the leading causes of neurodegenerative disorders. CBZ is dangerous to human health, the most common side effects upon chronic exposure are thyroid gland dysfunction and oxidative hepato-nephrotoxicity. In mammals, CBZ has been shown to disrupt the antioxidant defense system. In this review, CBZ-induced toxicity in different cells, tissues and organisms, under in vitro and in vivo conditions, has been systematically discussed.

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Section: Introductionmentioning

confidence: 99%

Carbendazim toxicity in different cell lines and mammalian tissues

Sharma

Maheshwari

Khan

et al. 2022

J Biochem & Molecular Tox

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“…The rats in the co-treatment group were given either 400 mg/kg of carbendazim and 0, 0.78, 3.13, 12.5 and 50 mg/kg/day of flutamide, or 50 mg/kg/day of flutamide and 0, 6.25, 25, 100 and 400 mg/kg/day of carbendazim for 7 days. All animal care and experimental procedures were approved by the Institution Animal Care and Use of Committee (IACUC) of TCATRI [30].…”

Section: Methodsmentioning

confidence: 99%

Androgen Receptor Plays a Vital Role in Benomyl- or Carbendazim-Induced Reproductive and Developmental Toxicity and Endocrine-Disrupting Activity in Rats

Lu¹

2018

Endocrine Disruptors

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Benomyl and its metabolite carbendazim were reported to induce reproductive and developmental toxicity and endocrine-disrupting activity in rats. The exactly underlying mechanism of reproductive and developmental toxicity and endocrine-disrupting activity still remain unclear. Based on our unpublished data it showed that the antiandrogen flutamide can completely recover the reproductive and developmental toxicity including embryolethality induced by benomyl and carbendazim in rats. This manuscript aimed to review and generalize the results based on our previous reports. Androgen receptor might play an important role in benomyl-and carbendazim-induced reproductive and developmental toxicity and endocrine-disrupting activity. The evidences were (1) androgen-and androgen receptor-dependent mechanisms are possibly involved in carbendazim-induced toxicity; (2) carbendazim exposure in utero displays a transient and weak androgenic effect and reduces flutamide antiandrogenicity in male rats; (3) antagonistic effect of flutamide on the carbendazim-androgenic effect on mRNA and protein levels; (4) benomyl and carbendazim exhibit an androgenic effect, leading to increase weight of ventral prostate and seminal vesicles and uterine fluid retention in young adult rats.The molecular underlying mechanism of reproductive and developmental toxicity and endocrine-disrupting activity induced by benomyl and carbendazim through androgen receptor need to be further investigated.

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“…Carbendazim has been also reported to induce dysfunction of the somatic Sertoli cells cell by inhibiting microtubule assembly in a colchicine-like manner [75,[82][83][84]. However, the mechanism of action of carbendazim was not fully elucidated, especially at low doses, even if its status of endocrine disruptor has been raised [85,86]. We tested 3 low concentrations of carbendazim: 50 nM, 500 nM and 5 μM.…”

Section: We Then Tested Pesticides Selected On the Basis Of Their Per...mentioning

confidence: 99%

An In Vitro Method to Study Male Reproductive Toxicology: A Review on the Bio-AlteR® Technology Allowing a “Physio-Toxicology” Approach

2022

J Pharmacol Pharm Res

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Carbendazim-induced androgen receptor expression antagonized by flutamide in male rats

Cited by 5 publications

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Carbendazim toxicity in different cell lines and mammalian tissues

Carbendazim toxicity in different cell lines and mammalian tissues

Androgen Receptor Plays a Vital Role in Benomyl- or Carbendazim-Induced Reproductive and Developmental Toxicity and Endocrine-Disrupting Activity in Rats

An In Vitro Method to Study Male Reproductive Toxicology: A Review on the Bio-AlteR® Technology Allowing a “Physio-Toxicology” Approach

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