Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose

Porto, Laura Cristina Jardim; Savergnini, Sílvia Silveira Quintão; Castro, Carlos H.; Mario, Érica Guilhen; Ferreira, Adaliene Versiani Matos; Santos, Sérgio Henrique Sousa; Andrade, Sílvia Passos; Santos, Robson A; Almeida, Alvair P.; Botion, Leida Maria

doi:10.1177/1753944710386282

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…The extracts were then assayed enzymatically using spectrophotometric methods (Pôrto et al, 2011). The total glycogen content was quantified by the anthrone assay (Pôrto et al, 2011). Serum triglycerides, total cholesterol and glycerol were assayed by conventional enzymatic methods using kits produced by Katal (Belo Horizonte, MG).…”

Section: Biochemical Analysismentioning

confidence: 99%

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Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid

et al. 2012

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Thus, in orotic acid hearts there was a simultaneous stimulus of fatty acid oxidation and glycolytic pathway, reflected in increased energetic content even in pre-ischemia. The analysis of the cardiac contractility index showed a positive inotropic effect of orotic acid due, at least in part, to the increased availability of energy. The result allows us to suggest that the metabolic changes induced by orotic acid result in appreciable alterations on myocardial contractile function.

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Section: Biochemical Analysismentioning

confidence: 99%

“…The extracts were then assayed enzymatically using spectrophotometric methods (Pôrto et al, 2011). The total glycogen content was quantified by the anthrone assay (Pôrto et al, 2011).…”

Section: Biochemical Analysismentioning

confidence: 99%

Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid

et al. 2012

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Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

et al. 2020

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Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. For the HCHD we found a mild effect on body weight gain and fasting blood glucose levels (FBG), but significant increases in triglycerides, fasting insulin, insulin resistance and visceral fat accumulation. HFD had the greater increase in the parameters previously mentioned, followed by HCHHFD, which had a modest effect on FBG levels. Therefore, to study early stages of MS a HCHD is recommended, while HFD and HCHHFD better reproduce more severe stages of MS. We recommend the assessment of visceral fat accumulation as a good estimate for obesity in the rat.

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Cellular Protection During Oxidative Stress: A Potential Role for D-ribose and Antioxidants

Addis

Shecterle²,

Cyr³

2012

Journal of Dietary Supplements

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A healthy cellular system involves the maintenance of an intracellular metabolic balance. Reactive oxygen species (ROS) are constantly produced as a normal product of cellular metabolism; however, during situations of cellular stress, these levels can increase dramatically with the potential to cause deleterious cellular structural and/or functional consequences. There is a significant elevation in these ROS following stressful situations, such as ischemia, hypoxia, high-intensity exercise, and in many diseases. To combat these ROS, neutralizing endogenous enzymes, as well as exogenous antioxidants, can aid in minimizing their potential untoward cellular effects. Exogenous reducing antioxidant agents, such as vitamin C and/or E, play a role in addressing these formed species; however, recent research has suggested that fruit seed extracts may provide additional cellular benefits beyond their antioxidant features. Furthermore, supplemental D-ribose enhances the recovery of high-energy phosphates following stress and appears to potentially offer additional benefits by reducing radical formation. Specifically, during periods of hypoxia/ischemia, supplemental D-ribose may play an inhibitory role in the breakdown of adenine nucleotides, influencing the subsequent formation of xanthine and uric acid compounds; and thereby affecting the release of superoxide anion radicals. The combination of D-ribose with reducing antioxidants may provide a more optimal state of cellular protection during and following times of oxidative stress.

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Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose

Abstract: Our data suggest that a high-carbohydrate diet can damage myocardial contractile function by decreasing the cardiac utilization of glucose and fatty acids and, consequently, the ATP pool.

Cited by 4 publications

References 45 publications

Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid

Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid

Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

Cellular Protection During Oxidative Stress: A Potential Role for D-ribose and Antioxidants

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