Carbohydrate metabolism in rats with chronic uremia

Abstract

In order to evaluate the effects of the chronic uremic syndrome upon some aspects of carbohydrate metabolism in vivo, determinations of gastric and intestinal glucose absorption, and of hepatic glycogen deposition were made in 39 chronically uremic rats and in 49 litter-mate controls. A surgical method for producing chronic uremia was developed. Rats fasted for 24 hours were given a glucose gavage of standard concentration. Three hours later residual gastric and intestinal glucose content and liver glycogen content were determined. No statistically significant difference between the two groups was found in either glucose absorption from the gastrointestinal tract or in glycogen deposition.

The effect of acute uræmia upon the survival of skin homografts. Histological changes in the regional lymph-nodes

“…None the less, it seems likely that the delayed immune response to skin homografts in acute uraemia is due principally to a depression of the metabolism of the antibody-forming cells in lymphoid tissue. There are differences of opinion as to whether carbohydrate metabolism is altered in uraemia (Kleeberg and Gitelson, 1956;Boucot, Nurser, and Merrill, 1960;Cummings and Zottu, 1960), and abnormalities of carbohydrate metabolism cannot be excluded as a cause of the impaired immune response in acute experimental uraemia. In this connexion it has been shown that certain adrenal cortical hormones markedly inhibit the glucose oxidation by suspensions of lymph-node cells in vitro (White, 1958).…”

Uremia and the Liver. III. Uremia and Hepatic Metabolism of Carbohydrates, Lipids and Proteins

“…No changes in glycogen synthesis or degradation have been reported in a number of studies carried out on liver slices from normal rats incubated with uremic serum [5] or in livers from uremic animals [8,[14][15][16]. However.…”