Carbohydrate-Restricted Diet: A Successful Strategy for Short-Term Management in Youth with Severe Obesity—An Observational Study

PAULEY, MEGHAN E.; Mays, Chadd; Bailes, James R.; Schwartzman, Michal Laniado; Castle, Mark; McCoy, Marji; Patick, Casey; Preston, Deborah L.; Nudelman, Matthew; Denning, Krista L.; Bellner, Lars; Werthammer, Joseph

doi:10.1089/met.2020.0078

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…STEP, the HL version of LCHF eating, is a safe dietary intervention for a carefully selected subset of pediatric patients with obesity who are trying to lose weight. Research in the use of LCHF diets for the management of pediatric obesity is scarce [21 ▪▪ ,22 ▪ ], and programs like STEP need to be rigorously studied. The use of telehealth may prove to be an effective way to maintain needed patient engagement in advanced dietary interventions.…”

Section: Discussionmentioning

confidence: 99%

Ketogenic diet as an advanced option for the management of pediatric obesity

Favret

Wood

Panayotti

2021

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review The Duke Healthy Lifestyles Program (HL), established in 2006, has treated over 15,000 pediatric patients with obesity. A subset of patients with obesity do not respond to dietary and lifestyle changes. Development of the Staged Transitional Eating Plan (STEP) in 2012 provided a ketogenic advanced dietary option for these specific patients. Recent findings The goal of STEP is to facilitate weight loss, while assuring adequacy and the promotion of health through the abundant inclusion of vegetables, fatty fish, nuts, olive oil, and other foods consistent with the Mediterranean Diet. STEP is a three-phase eating plan, each with a defined carbohydrate limit. STEP is ideal for patients eager to try a low carbohydrate diet, those with good vegetable acceptance, and those with families who are able to participate in the same eating plan as them. Summary STEP, the HL version of low carbohydrate high fat eating, is a safe dietary intervention for a carefully selected subset of pediatric patients with obesity who are trying to lose weight.

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Section: Discussionmentioning

confidence: 99%

Ketogenic diet as an advanced option for the management of pediatric obesity

Favret

Wood

Panayotti

2021

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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“…Regarding obesity, plasma and tissue 20-HETE levels increased in animal models of obesity and metabolic syndrome and strongly correlated with BMI in humans [9][10][11][12][13][14][15]. Lipid accumulation was shown to be stimulated by 20-HETE during adipogenesis in vitro [16], and a role of 20-HETE in the pathogenesis of diabetes was suggested [17,18].…”

Section: Introductionmentioning

confidence: 99%

Gpr75‐deficient mice are protected from high‐fat diet–induced obesity

Hossain

Gilani

Pascale

et al. 2023

Obesity

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Objective: G-protein coupled receptor 75 (GPR75) has been identified as the highaffinity receptor of 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoactive and proinflammatory lipid, and mice overproducing 20-HETE have been shown to develop insulin resistance when fed a high-fat diet (HFD), which was prevented by a 20-HETE receptor blocker. Simultaneously, a large-scale exome sequencing of 640,000 subjects identified an association between loss-of-function GPR75 variants and protection against obesity.Methods: Wild-type (WT) and Gpr75-deficient mice were placed on HFD for 14 weeks, and their obesity phenotype was examined.Results: Male and female Gpr75 null (knockout [KO]) and heterozygous mice gained less weight than WT mice when placed on HFD. KO mice maintained the same level of energy expenditure during HFD feeding, whereas WT mice showed a significant reduction in energy expenditure. Diet-driven adiposity and adipocyte hypertrophy were greatly lessened in Gpr75-deficient mice. HFD-fed KO mice did not develop insulin resistance. Adipose tissue from Gpr75-deficient mice had increased expression of thermogenic genes and decreased levels of inflammatory markers. Moreover, insulin signaling, which was impaired in HFD-fed WT mice, was unchanged in KO mice.Conclusions: These findings suggest that GPR75 is an important player in the control of metabolism and glucose homeostasis and a likely novel therapeutic target to combat obesity-driven metabolic disorders.

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“…Subsequently , the decreased weight could be an approach to avoid potential risks for severe COVID-19 . (36) Importantly, a dietary approach that lowers serum glucose concentrations should be considered as a first choice, to avoid or diminish Sars-Cov-2 infection risks and complications (37). Furthermore , low glycemic index diets provide more stable profiles, lowering the postprandial hyperglycaemia and hyperinsulinaemia, and decreasing the late postprandial rebound in free fatty acids in the blood , all factors that exaggerate the metabolic syndromes .…”

Section: Introductionmentioning

confidence: 99%

Nutritional fat modulation as a non-pharmacological approach to children infected with COVID-19, a challenge in food biochemistry.

Atef

2021

Egypt. J. Chem.

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WHO confirmed that COVID-19 disease is a pandemic event on March 11, 2020. The causative organism is a new virus called SARS-CoV-2. The review aims to explore the effect of nutrition-in particular the fat component -on the COVID-19 course in pediatrics. In this review, I will explain the relationship between the dietary fat component and its role as a macronutrient in the modulation of the disease severity or the prevention. The modification could be in the type or the amount of the dietary fat. To illustrate, it is advisable to avoid the saturated and trans-fatty acids due to their links to obesity with subsequent raised risks for COVID -19. In addition, the amount of dietary fat can be ameliorated to yield better disease outcomes. To illustrate, the ketogenic diet (high fat diet) provides the betahydroxybutrate which has favorable effects on the immunity suppressing and delaying the cytokine storms.

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Carbohydrate-Restricted Diet: A Successful Strategy for Short-Term Management in Youth with Severe Obesity—An Observational Study

Cited by 7 publications

References 38 publications

Ketogenic diet as an advanced option for the management of pediatric obesity

Ketogenic diet as an advanced option for the management of pediatric obesity

Gpr75‐deficient mice are protected from high‐fat diet–induced obesity

Nutritional fat modulation as a non-pharmacological approach to children infected with COVID-19, a challenge in food biochemistry.

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