Carbohydrate-restricted diet alters the gut microbiota, promotes senescence and shortens the life span in senescence-accelerated prone mice

He, Chaoqi; Wu, Qiming; Hayashi, Naohito; Nakano, Fumika; Nakatsukasa, Eriko; Tsuduki, Tsuyoshi

doi:10.1016/j.jnutbio.2019.108326

Cited by 16 publications

(11 citation statements)

References 48 publications

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“…Frontiers in Pharmacology | www.frontiersin.org January 2021 | Volume 11 | Article 600219 functions will be degraded, and the heart, liver, spleen, and kidney indexes will decline to some extent (He et al, 2020;. Parallel research results appeared in this study.…”

Section: Discussionsupporting

confidence: 77%

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Yang

Tan

et al. 2021

Front. Pharmacol.

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Ilex kudingcha C.J. Tseng tea and insect tea, as traditional Chinese teas, are favored for their original craftsmanship, unique flavor, and biological functionality. In this study, ultra high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS) was used to analyze the bioactive components of the extracts of Ilex kudingcha and insect tea, and D-galactose-induced aging mice were used to compare the in vivo anti-aging effects of Ilex kudingcha and insect tea extracts. The results were remarkable, UHPLC-QqQ-MS analysis showed that ITP contains 29 ingredients, while IKDCP contains 26 ingredients. However, due to the large differences in the content of the main chemical components in IKDCP and ITP, the effects are equally different. At the same time, the in vivo research results suggesting that the anti-aging effects of IKDCP and ITP (500 mg/kg) include the regulation of viscera indices of major organs; improvement in liver, skin, and spleen tissue morphology; decreased production of inflammatory cytokines; up regulation of SOD, CAT, GSH, GSH-PX, and T-AOC and down regulation of NO and MDA levels in serum and liver tissue; reductions in the concentration of pro-inflammatory factors, and increases in the concentration of anti-inflammatory factor. RT-qPCR and western blot assay also showed that IKDCP and ITP affect anti-aging by regulating the gene and protein expression of GSH-PX, GSH1, SOD1, SOD2, and CAT. The overall results indicate that ITP is more effective in treating oxidative damage in aging mice induced by D-galactose. Thus, ITP appears to be an effective functional drink owing to its rich nutritional components and anti-aging activities.

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Section: Discussionsupporting

confidence: 77%

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Yang

Tan

et al. 2021

Front. Pharmacol.

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“…(20) These effects are mediated by the activation of stress kinase c-jun N-terminal kinase 2 via generation of ROS and lipid peroxidation by the ion-driven Fenton reaction. (10) Therefore, to eliminate the effects of ROS generated by UVB, antioxidants, such as superoxide dismutase (SOD), glutathione peroxidase (Gpx), catalase, and forkhead box O1 (Foxo1) are expressed in the skin tissue.…”

Section: Discussionmentioning

confidence: 99%

“…(6,7) Moreover, the administration of LC diets has also been reported to accelerate aging and cause heart disease, hence raising questions about their safety. (8)(9)(10)(11)(12) In recent years, many media outlets have promoted LC diets for the maintenance of good health (i.e., to prevent aging and obesity), causing a subsequent increase in the number of people following these diets, even among nonobese individuals. Meanwhile, a decrease in dietary carbohydrate levels has been found to be accompanied by an increase in dietary fat and protein levels.…”

mentioning

confidence: 99%

Low-carbohydrate diets adversely impact the skin of a mouse model of photoaging exposed to ultraviolet B radiation

Kanaki

Otsuka

Hino

et al. 2022

J. Clin. Biochem. Nutr.

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The study results regarding the effects of low-carbohydrate (LC) diets remain controversial; hence further research is required to assess their safety. Here, we examined whether LC diets cause skin damage in C57BL/6J mice. Six-week-old female mice (n = 20) were fed an LC (protein/fat/carbohydrate energy ratio = 35:45:20) or control diet ad libitum for eight weeks, after which their backs were shaved, and a subset of the mice were exposed to ultraviolet B radiation thrice per week. Ultraviolet B irradiation induced wrinkle formation on the skin surface, and thickening of the epidermis, which was also noticeable in the LC diet-fed mice in the absence of ultraviolet B radiation. Meanwhile, the number of epidermal melanocytes and degree of horny layer keratosis increased in the LC diet-fed mice following ultraviolet B irradiation. mRNA expression analysis of the liver and skin showed decreased levels of the antioxidant enzyme superoxide dismutase 1 following ultraviolet B irradiation only in the LC diet-fed mice. Alternatively, the expression of pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, increased in response to ultraviolet B radiation and LC diet intake. Hence, LC diets may adversely affect skin morphology and exacerbate the effects of ultraviolet B irradiation, which may be associated with antioxidant dysfunction.

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“…Increasing research in humans and other vertebrates have shown that the intestinal microbiota plays an important role in carbohydrate degradation and fermentation [26,27]. In aquaculture, how to increase the carbohydrate utilization efficiency and alleviate the metabolic syndrome caused by an HCD is vitally important.…”

Section: Discussionmentioning

confidence: 99%

A strain affiliated to Bacillus amyloliquefaciens alleviates high-carbohydrate diet- induced metabolic syndrome by restoration of acetate-producing bacteria in fish intestines

Xu¹,

Li²,

Wang³

et al. 2020

Preprint

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Background: Increasing the utilization efficiency of high-carbohydrate diet has the potential to promote “protein sparing effects” in farmed fish; however, many fish utilize carbohydrates poorly. The intestinal microbiota plays an important role in carbohydrate degradation. Whether the addition of functional bacteria could increase the carbohydrate utilization efficiency and alleviate high-carbohydrate diet-induced adverse effects is unknown.Results: A bacterial strain that could degrade starch in vitro was isolated from the intestines of Nile tilapia (Oreochromis niloticus). The bacterium was affiliated to Bacillus amyloliquefaciens (designated as B. amy SS1) based on 16S rRNA gene sequencing. Three diets, including control diet (CON), high-carbohydrate diet (HCD), and high-carbohydrate diet supplemented with B. amy SS1 (HCB), were used to feed Nile tilapia for 10 weeks. The beneficial effects of B. amy SS1 on weight gain and protein accumulation were observed. The HCB decreased blood glucose levels and reduced lipid deposition compared with the HCD group. To detect the possible mechanism, the intestinal microbiota composition was characterized using high-throughput sequencing. The HCB increased the abundance of short-chain fatty acid-producing bacteria. Gas chromatographic analysis indicated that theconcentration of acetate increased dramatically in the HCB group compared with that in the HCD group. Glucagon-like peptide-1 (GLP-1) levels increased in the intestine and serum of the HCB group. Different concentrations of sodium acetate (low (HLA), 900 mg/kg; medium (HMA), 1800 mg/kg, and high (HHA), 3600 mg/kg) were added to the HCD to feed the fish for eight weeks. The HMA and HHA groups mirrored the effects of the HCD supplemented with B. amy SS1 by increasing serum GLP-1 levels. Increased acetate concentrations stimulated GLP-1 production, which might account for the effects caused by the addition of B. amy SS1 to the HCD.Conclusions: This study systematically analyzed the influence of B. amy SS1 on fish metabolism, suggesting that B. amy SS1 treatment alleviates the metabolic syndrome caused by HCD by enriching acetate-producing bacteria in fish intestines. Regulating the intestinal microbiota and their metabolites might represent a powerful strategy for fish nutrition modulation and health maintenance in future.

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Carbohydrate-restricted diet alters the gut microbiota, promotes senescence and shortens the life span in senescence-accelerated prone mice

Cited by 16 publications

References 48 publications

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Low-carbohydrate diets adversely impact the skin of a mouse model of photoaging exposed to ultraviolet B radiation

A strain affiliated to Bacillus amyloliquefaciens alleviates high-carbohydrate diet- induced metabolic syndrome by restoration of acetate-producing bacteria in fish intestines

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