Carbon-based nanodots as effective electrochemical sensing tools toward the simultaneous detection of bioactive compounds in complex matrices

Montes, Cristina; Soriano, M. Laura; Llerena, M. J. Villaseñor; Ríos, Ángel

doi:10.1016/j.jelechem.2020.114573

Cited by 15 publications

(7 citation statements)

References 34 publications

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“…As shown in Figure b, the CV curves of K 3 [Fe(CN) 6 ] were measured for SPE, M-SPE, and C-SPE. The C-SPE showed the largest peak current and lowest oxidation potential, attributed to CQDs’ well-known excellent electrocatalytic activity in the reduction of oxidative reactions potential. − The k 0′ was utilized to study the kinetics of the electron transfer process, which was obtained using the Nicholson method in Table S1 (eq S1). The C-SPE showed much higher k 0′ (7.17 × 10 –3 cm/s) than that of M-SPE (3.95 × 10 –3 cm/s) and SPE (1.69 × 10 –3 cm/s).…”

Section: Resultsmentioning

confidence: 99%

An Integrated Sweat Sensor for Synchronous Detection of Multiple Atherosclerosis Biomarkers

Wei,

Zhang,

Chang

et al. 2023

Anal. Chem.

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Atherosclerosis conditions are often assessed in the clinic by measuring blood viscosity, blood flow, and blood lesion levels. In alignment with precision medicine, it is essential to develop convenient and noninvasive approaches for atherosclerosis diagnostics. Herein, an integrated electrochemical sensor was successfully demonstrated for simultaneously detecting cholesterol, transferrin, and K+ in sweat, all biomarker indicators of atherosclerosis. The sensing substrate was based on carbon quantum dots integrated within multiwalled carbon nanotubes, creating a hybrid framework with low electron transfer resistance and highly efficient electron transfer rate, yielding a highly electrochemical active platform for ultrasensitive detection of trace sweat biomarkers. To ensure specificity to corresponding targets, the sensing mechanisms were based on molecular recognition reactions of cholesterol and β-cyclodextrin, transferrin and molecular cavities, and K+ and ion-selective permeation membrane. Moreover, the integrated nonenzymatic sensor exhibited excellent long-term stability. Furthermore, the practical utility of the sensor was successfully demonstrated by the simultaneous detection of three atherosclerosis biomarkers in sweat from volunteers who underwent predesigned daily activities. The sensor shows promise for convenient indexing of atherosclerosis conditions in a noninvasive way.

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Section: Resultsmentioning

confidence: 99%

An Integrated Sweat Sensor for Synchronous Detection of Multiple Atherosclerosis Biomarkers

Wei,

Zhang,

Chang

et al. 2023

Anal. Chem.

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“…10,11 Because of excellent optical and electrochemical properties, non-toxicity, easy and green synthesis methods from a vast number of simple and cheap precursors, CQDs are becoming important parts of different chemical sensors. [12][13][14][15] As literature shows, application of CQDs as ECL luminophore was firstly reported by two studies in 2009; Zheng et al, synthesised CQDs from graphite by using an electrochemical method and showed that CQDs have cathodic ECL properties in phosphate buffer solution (PBS) solution. 16 Later Zhu and his coworkers reported anodic ECL properties of CQDs that were synthesised by a microwave-assisted method from saccharides and polyethylene glycol precursors.…”

Section: Electrogeneratedmentioning

confidence: 99%

Electrochemiluminescence Sensor Based on N-Doped Carbon Quantum Dots for Determination of Ceftazidime in Real Samples

Afshary

Amiri

Bezaatpour

et al. 2022

J. Electrochem. Soc.

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We report an electrochemiluminescence (ECL) sensor based on nitrogen doped carbon quantum dots (N-CQDs), which has been synthesized by a solvothermal method. The N-CQDs were characterized using various techniques such as high-resolution transmission electron microscopy, field emission scanning electron microscopy, UV-Vis absorption and photoluminescence spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The potential sweep range (−0.5 to −2.2 V) shows a stable and strong ECL signal. Interestingly, the ECL intensity only decreased by less than 20% after storing at 4°C for 10 months. The applicability of the N-CQD sensor in electroanalytical chemistry was identified by the linear ECL on–off response for ceftazidime in a concentration range from 1×10-7 to 5×10-4 mol L–1 and a detection limit of 2.3×10-8 mol L–1. The results suggest that the proposed ECL sensor is robustly applicable for analysis of ceftazidime in real samples such as human serum, bovine milk, and commercial milk powder.

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“…GQDs were prepared from graphene using the top-down methodology previously described elsewhere [26,27] with variations. Graphene (0.02 g) were refluxed in acid conditions (20 mL of a mixture of H 2 SO 4 /HNO 3 at 3:1 [v/v] ratio) at two reaction times, 1 and 5 h. Then, the resultant mixtures were cooled down and divided into two portions, being one portion of each synthesis treated with acetone (5 mL) for surface passivation.…”

Section: Preparation Of the Passivated And Nonpassivated Gqdsmentioning

confidence: 99%

Passivated graphene quantum dots for carbaryl determination in juices

Soriano

Jiménez-Sánchez

Cárdenas

2021

J of Separation Science

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This paper reports a simple method for the preparation of suitable graphene quantum dots after surface passivation, to be used for the determination of carbaryl in juice samples. A comparison of synthetic conditions for the preparation of graphene quantum dots following the top-down approach is described. In the one-step route selected, evaluation of diverse reaction time for cutting and modulating the oxidizing sites in the broken pieces of the initial graphene layer is conducted with a mixture of concentrated acids. Exploring the passivation effect on the purified graphene quantum dots, we demonstrated the suitability of the selected graphene quantum dots for practical application in the detection of carbaryl using fluorometric detection. Higher sensitivity was achieved after 8 min of contact, in which graphene quantum dots promotes the degradation of carbaryl into naphthol, being the latter responsible for the analytical signal. The detection and quantification limits were 0.36 and 1.21 μg/L, respectively, being the response linear up to 26 μg/L with excellent precision (better than 3.2% at the limit of detection). The recovery of the analyte from commercial juice samples (91.4-96.7%) testifies to the applicability of the proposal for the analytical problem selected.

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Carbon-based nanodots as effective electrochemical sensing tools toward the simultaneous detection of bioactive compounds in complex matrices

Cited by 15 publications

References 34 publications

An Integrated Sweat Sensor for Synchronous Detection of Multiple Atherosclerosis Biomarkers

An Integrated Sweat Sensor for Synchronous Detection of Multiple Atherosclerosis Biomarkers

Electrochemiluminescence Sensor Based on N-Doped Carbon Quantum Dots for Determination of Ceftazidime in Real Samples

Passivated graphene quantum dots for carbaryl determination in juices

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