Carbon-based SERS biosensor: from substrate design to sensing and bioapplication

Liang, Xiu; Li, Ning; Zhang, Runhao; Yin, Ping; Zhang, Chenmeng; Yang, Nan; Liang, Kang; Kong, Biao

doi:10.1038/s41427-020-00278-5

Cited by 195 publications

(106 citation statements)

References 245 publications

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“…Although the prospects for the use of CDs in nanomedicine are broad, the potential risks arising from interactions between CDs and biological systems must also be considered [50,55,56]. We have already published several papers focusing on the biological use and cytotoxicity of different types of carbon dots [46,53,57].…”

Section: Biocompatibility Of Carbon Dotsmentioning

confidence: 99%

Carbon dots for virus detection and therapy

2021

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Recent experience with the COVID-19 pandemic should be a lesson learnt with respect to the effort we have to invest in the development of new strategies for the treatment of viral diseases, along with their cheap, easy, sensitive, and selective detection. Since we live in a globalized world where just hours can play a crucial role in the spread of a virus, its detection must be as quick as possible. Thanks to their chemical stability, photostability, and superior biocompatibility, carbon dots are a kind of nanomaterial showing great potential in both the detection of various virus strains and a broad-spectrum antiviral therapy. The biosensing and antiviral properties of carbon dots can be tuned by the selection of synthesis precursors as well as by easy post-synthetic functionalization. In this review, we will first summarize current options of virus detection utilizing carbon dots by either electrochemical or optical biosensing approaches. Secondly, we will cover and share the up-to-date knowledge of carbon dots’ antiviral properties, which showed promising activity against various types of viruses including SARS-CoV-2. The mechanisms of their antiviral actions will be further adressed as well. Finally, we will discuss the advantages and distadvantages of the use of carbon dots in the tangled battle against viral infections in order to provide valuable informations for further research and development of new virus biosensors and antiviral therapeutics. Graphical abstract

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Section: Biocompatibility Of Carbon Dotsmentioning

confidence: 99%

Carbon dots for virus detection and therapy

2021

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“…Owing to the unique structural characteristics of carbon, since 2000, carbon-based nanomaterials such as carbon nanotubes, carbon nanofibers, graphene, and graphene oxide have been used for the development of electrochemical, electrical, and spectroscopic biosensors [ 80 , 81 , 82 , 83 ]. Recently, a new type of structural layer called MXene was developed, which improved the scalability of the applicability of biosensors [ 52 , 84 ].…”

Section: Carbon Nanomaterial-based MC Biosensormentioning

confidence: 99%

Improving Biosensors by the Use of Different Nanomaterials: Case Study with Microcystins as Target Analytes

et al. 2021

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The eutrophication of lakes and rivers without adequate rainfall leads to excessive growth of cyanobacterial harmful algal blooms (CyanoHABs) that produce toxicants, green tides, and unpleasant odors. The rapid growth of CyanoHABs owing to global warming, climate change, and the development of rainforests and dams without considering the environmental concern towards lakes and rivers is a serious issue. Humans and livestock consuming the toxicant-contaminated water that originated from CyanoHABs suffer severe health problems. Among the various toxicants produced by CyanoHABs, microcystins (MCs) are the most harmful. Excess accumulation of MC within living organisms can result in liver failure and hepatocirrhosis, eventually leading to death. Therefore, it is essential to precisely detect MCs in water samples. To date, the liquid chromatography–mass spectrometry (LC–MS) and enzyme-linked immunosorbent assay (ELISA) have been the standard methods for the detection of MC and provide precise results with high reliability. However, these methods require heavy instruments and complicated operation steps that could hamper the portability and field-readiness of the detection system. Therefore, in order for this goal to be achieved, the biosensor has been attracted to a powerful alternative for MC detection. Thus far, several types of MC biosensor have been proposed to detect MC in freshwater sample. The introduction of material is a useful option in order to improve the biosensor performance and construct new types of biosensors. Introducing nanomaterials to the biosensor interface provides new phenomena or enhances the sensitivity. In recent times, different types of nanomaterials, such as metallic, carbon-based, and transition metal dichalcogenide-based nanomaterials, have been developed and used to fabricate biosensors for MC detection. This study reviews the recent advancements in different nanomaterial-based MC biosensors.

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“…To date, an enormous number of electrochemical sensors and biosensors are reported based on CNMs that have superior performance in terms of sensitivity, stability, reusability, and reproducibility. However, the functionalization or modification with metal nanoparticles, enzymes, polymers, and heteroatom doping can improve their physiochemical properties and offers a great platform for diverse electrochemical biosensor methods [ 54 , 55 ]. On the other hand, the integration of CNMs with the functional ILs can turn to high-performance, hybrid nanostructured materials with superior properties even compared to the pure ILs and CNMs.…”

Section: Introductionmentioning

confidence: 99%

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

et al. 2021

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Ionic liquids are gaining high attention due to their extremely unique physiochemical properties and are being utilized in numerous applications in the field of electrochemistry and bio-nanotechnology. The excellent ionic conductivity and the wide electrochemical window open a new avenue in the construction of electrochemical devices. On the other hand, carbon nanomaterials, such as graphene (GR), graphene oxide (GO), carbon dots (CDs), and carbon nanotubes (CNTs), are highly utilized in electrochemical applications. Since they have a large surface area, high conductivity, stability, and functionality, they are promising in biosensor applications. Nevertheless, the combination of ionic liquids (ILs) and carbon nanomaterials (CNMs) results in the functional ILs-CNMs hybrid nanocomposites with considerably improved surface chemistry and electrochemical properties. Moreover, the high functionality and biocompatibility of ILs favor the high loading of biomolecules on the electrode surface. They extremely enhance the sensitivity of the biosensor that reaches the ability of ultra-low detection limit. This review aims to provide the studies of the synthesis, properties, and bonding of functional ILs-CNMs. Further, their electrochemical sensors and biosensor applications for the detection of numerous analytes are also discussed.

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Carbon-based SERS biosensor: from substrate design to sensing and bioapplication

Cited by 195 publications

References 245 publications

Carbon dots for virus detection and therapy

Carbon dots for virus detection and therapy

Improving Biosensors by the Use of Different Nanomaterials: Case Study with Microcystins as Target Analytes

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

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