Carbon dioxide laser treatment of extensive pigmented viral plaque lesions in a golden retriever dog

Knight, Evie C.; Munday, John S.; Stone, Brett M.; Shipstone, Michael A.

doi:10.1111/vde.12350

Cited by 16 publications

(19 citation statements)

References 20 publications

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“…Other options we considered in these patients included the use of conventional surgery (e.g. en bloc resection of the severely affected portion of skin, followed by reconstructive surgical techniques), cryosurgery (Krahwinkel 1980) or the application of a medical laser to destroy individual plaques (Persky 1984;Knight et al 2016). In terms of medical therapy, a-interferon, retinoids and 5-flourouracil could also be considered.…”

Section: Discussionmentioning

confidence: 99%

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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Cutaneous pigmented viral plaques is a disorder of epidermal growth caused by canine papillomavirus type 4 (CPV‐4). There is currently no standard of care for managing this condition and it has not been reported in the Hungarian Vizsla. This case series documents the clinical features of canine pigmented viral plaques in Hungarian Vizsla dogs and the treatment of a severe case using a novel topical agent tigilanol tiglate (EBC‐46). A 4‐year‐old spayed Hungarian Vizsla in Australia was presented for multiple cutaneous pigmented plaques extending from the ventral cervical region. Lesions were neither painful nor pruritic. The number and size of these sessile plaques increased over time, with the largest lesions eventually taking on an exophytic (wart‐like) appearance. These lesions did not affect the dog's wellbeing. Two much less severe cases in a 5‐year‐old Vizsla from the UK and a 7‐year‐old Vizsla from New Zealand were also diagnosed. Histology was consistent with papillomavirus‐induced pigmented plaques and CPV‐4 DNA sequences were amplified from paraffin‐embedded formalin‐fixed tissue using the polymerase chain reaction from the most severely affected patient. Topical imiquimod was ineffective although used for only a short time. Two topical applications of novel anti‐neoplastic diterpene ester tigilanol tiglate as a gel, 9 days apart, greatly reduced the size and number of lesions in a limited portion of skin treated, over the lateral hock. While CPV‐4 has been previously reported to cause pigmented plaques, most commonly on pug dogs, but sporadically on other breeds, this is the first report of this virus causing plaques in Hungarian Vizslas. The cases illustrate some of the difficulties in diagnosing papillomavirus‐induced disease in dogs, especially in its early stages. Topical tigilanol tiglate is a potentially useful topical therapy for this viral‐induced disorder of cell growth and represents a treatment deserving of further investigation.

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Section: Discussionmentioning

confidence: 99%

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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“…Jedynym pewnym sposobem leczenia wrodzonych brodawczaków jest ich chirurgiczne usunięcie. Stosowanie lasera CO 2 jest szeroko rozpowszechnione w medycynie człowieka, jak i małych zwierząt do usuwania zmian w chirurgii miękkiej, okulistyce, stomatologii czy dermatologii (2,4,12,15). Światło laserowe jest pochłaniane głównie przez wodę wewnątrzkomórkową i zewnątrzkomórkową, w wyniku fototermicznej interakcji laser-tkanka, co umożliwia precyzyjne cięcie tkanek (4,20).…”

Section: Opis Przypadkuunclassified

“…Zamknięcie naczyń krwionośnych skutkuje natomiast znacznym zmniejszeniem krwawienia, a co za tym idzie -mniejszym ryzykiem infekcji. W porównaniu do klasycznych zabiegów chirurgicznych, laserowa ekstrakcja jest mniej bolesna oraz pozwala na powstanie mniejszej blizny, co ma znaczenie zwłaszcza w przypadku zmian w okolicy głowy czy pyska u zwierząt pokazowych (4,8,11). W przypadku koni operowanych w pozycji stojącej, niezwykle ważne jest również ograniczenie ilości dodatkowego sprzętu, który może powodować dyskomfort i stres u zwierzęcia, zwłaszcza młodego (5,9).…”

Section: Opis Przypadkuunclassified

Congenital skin papilloma in a foal – a case of a surgical CO2 laser treatment

Siwińska

Żak

Słowikowska

et al. 2019

Medycyna Weterynaryjna

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Skin papilloma in humans and animals is a relatively common dermatological problem. The most common form of these changes are acquired papillomas, and while congenital ones are rare, they were most often described in humans and horses. The present article describes the first case in Poland of congenital single skin papilloma in a newborn thoroughbred foal, surgically removed using a CO2 laser. The treatment was carried out after 3 months from birth when the change began to progress. Removal was performed on the standing animal with pharmacological sedation. Histopathological examination confirmed the diagnosis. The convalescence process proceeded without complications, with quick healing and no scar remaining.

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“…In humans, CO 2 laser is considered one of the best treatment modalities for genital warts. 51 As this modality was recently used to successfully treat numerous large viral plaques on a dog, 52 CO 2 laser could be a useful treatment for larger lesions in cats.…”

Section: Treatment Approachesmentioning

confidence: 99%

Novel viruses: Update on the significance of papillomavirus infections in cats

Munday

Sharp

Beatty

2018

Journal of Feline Medicine and Surgery

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Practical relevance: Prior to 1990 papillomaviruses (PVs) were not recognised to infect or cause disease in domestic cats. Since this time, the use of histology, immunohistochemistry and, more recently, molecular techniques has revealed that PVs almost certainly cause feline viral plaques and Bowenoid in situ carcinomas, oral papillomas and feline sarcoids. In addition, there is increasing evidence that PVs play a significant role in the development of feline cutaneous squamous cell carcinomas, one of the most common skin cancers of cats. Recent studies have also revealed that most cats are asymptomatically infected with PVs. This raises a critical question that is currently unanswered: why do only a small proportion of infected cats develop disease? In the future it may be possible to prevent PV-induced diseases by using a vaccine to prevent PV infection. Alternatively, novel therapies may be developed that prevent PVs from causing clinical disease by stimulating the host immune response. Clinical challenges: A recognition of the skin diseases caused by PVs is important to more accurately predict disease progression. Unfortunately, there are currently no non-surgical treatments that have been proven to be beneficial in cats and clinical management of PV-induced skin disease in cats can be challenging. Global importance: PVs have a worldwide distribution and negatively impact feline health and welfare globally. Audience: This review is aimed at clinicians, especially those who regularly treat cats with skin disease. The review will also be useful to oncologists and researchers who have an interest in how cancer develops in cats. Evidence base: In producing this update the authors have drawn on recently published peer-reviewed literature.

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Carbon dioxide laser treatment of extensive pigmented viral plaque lesions in a golden retriever dog

Cited by 16 publications

References 20 publications

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Congenital skin papilloma in a foal – a case of a surgical CO2 laser treatment

Novel viruses: Update on the significance of papillomavirus infections in cats

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