Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

Abstract

The overview presented here has the goal of examining whether carbon disulfide (CS 2 ) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro-and reproductive system toxicity of CS 2 has been documented from its long-term use in the viscose rayon industry. CS 2 is also used in the production of dithiocarbamates (DTCs), which are potent fungicides and pesticides, thus raising concern that CS 2 may be an environmental toxin. However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings as well as having potency for reducing inflammation. Three known small molecule bioregulators (SMBs) nitric oxide, carbon monoxide, and hydrogen sulfide were initially viewed as environmental toxins. Yet each is now recognized as having intricate, though not fully elucidated, biological functions at concentration regimes far lower than the toxic doses. The literature also implies that the mammalian chemical biology of CS 2 has broader implications from inflammatory states to the gut microbiome. On these bases, we suggest that the very nature of CS 2 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es), much like other SMBs. TOC Image 1 CONTENTS

Kinetic Insights into Hydrogen Sulfide Delivery from Caged-Carbonyl Sulfide Isomeric Donor Platforms

“…Recent studies suggest that CS 2 may have has specific protective activities in biological systems, and may be an emerging biologically-relevant sulfur-containing small molecule. 76 Aligned with this idea, we prepared PeroxyDTCM-1 and 2 , both of which cage CS 2 into dithiocarbamate compounds. Much like H 2 O 2 -labile PeroxyTCMs and PeroxyTCNs , the PeroxyDTCMs should be activated by H 2 O 2 to generate anionic dithiocarbamate intermediates, which could release CS 2 instead of COS. (Scheme 3).…”

Pengujian H2S dan CS2 Dalam Emisi Sumber Tidak Bergerak Industri Rayon

“…CS 2 diproduksi secara industrial melalui proses pemanasan karbon seperti arang atau gas alam dengan sulfur sejak abad ke 19 (17). Saat itu efek merugikan pada pekerja yang terpajan di industri rayon viskos mulai teridentifikasi (17).…”

Cleavage of Carbon Disulfide by n‐Propyldiphenylphosphine and Nickel(II) Bromide

“…Industrially, carbon disulfide is used to produce viscose rayon in bulk quantities, which can be used in apparel and in cellophane production . Carbon disulfide is reacted with a primary or secondary alcohol and a metal hydroxide to form a xanthate, which is then decomposed via an acid catalyzed disproportionation to produce viscose rayon, water, and regenerated carbon disulfide . Measures are in place to recover the carbon disulfide used in the manufacturing process, as it is has been found to be harmful to human health and the environment.…”

“…[2,3] Carbon disulfide is reacted with ap rimary or secondary alcohol and am etal hydroxide to form ax anthate, which is then decomposed via an acid catalyzed disproportionation to produce viscoser ayon, water,a nd regenerated carbon disulfide. [4] Measures are in place to recover the carbon disulfideu sed in the manufacturing process, as it is has been found to be harmful to human health and the environment. The most common trace precursor to sulfur dioxide in the stratosphere and troposphere is carbonyl sulfide, COS, which is an intermediate speciesi nt he hydrolysis of carbon disulfide.…”

“…[22] In another case shown in reaction(3), carbon disulfide can insert into the metal phosphine bond to form az witterion (R 3 P + -CS 2 À )a sabidentate ligand. [23,24] Additionally,c arbon disulfide can also react with a phosphine to cleave the carbon-sulfur bond to form at erminally bound CS ligand and ap hosphine sulphide as depicted in reaction (4). [25,26] Some nickel-phosphine complexese xhibit unusualr eactivity with carbon disulfide.…”