Carbon dot-based biosensors for the detection of communicable and non -communicable diseases

Barrientos, Kaory; Arango, Juan Pablo; Moncada, Manuel Santiago; Plácido, Jersson; Patiño, Juliana; Macías, Sara Legny; Maldonado, Camilo; Torijano, Sandra; Bustamante, Sandra; Londoño, Martha Elena; Jaramillo, Marisol

doi:10.1016/j.talanta.2022.123791

Cited by 29 publications

(8 citation statements)

References 222 publications

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“…For example, various chemical substances, ions, biomolecules, and even whole cells or tissues can be detected with biosensors specifically designed for use in cancer research. Because carbon dots enhance fluorescence or enable measurement of lower enzyme concentrations, carbon dot-based biosensors can be used as a platform to improve the measurement of enzyme activities associated with cancer and other diseases 200,201. Colorectal cancer detection has benefited greatly from nanomedicine's increased sensitivity, lower cost, and reduced over-and underdiagnosis.…”

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confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

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In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach to improve the drug delivery system for tumour and cancer diseases. In this article, we review current strategies to improve tumour and cancer drug delivery, which mainly focuses on sustaining biocompatibility, biodistribution, and active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, and paclitaxel has its own challenges especially not being able to discriminate between tumour versus normal cells which eventually led to toxicity and side effects in the patients. In contrast to the conventional approach, nanoparticle-based drug delivery provides target-specific delivery and controlled release of the drug, which provides a better therapeutic window for treatment options by focusing on the eradication of diseased cells via active targeting and sparing normal cells via passive targeting. Additionally, treatment of tumours associated with the brain is hampered by the impermeability of the blood-brain barriers to the drugs, which eventually led to poor survival in the patients. Nanoparticle-based therapy offers superior delivery of drugs to the target by breaching the blood-brain barriers. Herein, we provide an overview of the properties of nanoparticles that are crucial for nanotechnology applications. We address the potential future applications

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mentioning

confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

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“…Additionally, the repeatability, stability, and selectivity of optical fiber probes were evaluated with promising results. CQDs-based biosensors have recently been primarily developed for use in clinical analysis and disease detection [35][36][37][38]. Building on the exceptional photoluminescence, electro-chemiluminescence, and electrochemical behavior of GQD, these have been widely used to detect biological macromolecules, such as DNA, RNA, protein, or glucose molecules, with improved selectivity and sensitivity.…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

“…Carbon dots (CD) are an alternative to QDs in biosensing applications due to their low toxicity and biocompatibility. Most sensor platforms with CD are based on biological solution [35,42]. CD aqueous solution is unstable for a long time, and enzymes denature in water when stored for a long time.…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Optically Active Nanomaterials and Its Biosensing Applications—A Review

et al. 2023

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This article discusses optically active nanomaterials and their optical biosensing applications. In addition to enhancing their sensitivity, these nanomaterials also increase their biocompatibility. For this reason, nanomaterials, particularly those based on their chemical compositions, such as carbon-based nanomaterials, inorganic-based nanomaterials, organic-based nanomaterials, and composite-based nanomaterials for biosensing applications are investigated thoroughly. These nanomaterials are used extensively in the field of fiber optic biosensing to improve response time, detection limit, and nature of specificity. Consequently, this article describes contemporary and application-based research that will be of great use to researchers in the nanomaterial-based optical sensing field. The difficulties encountered during the synthesis, characterization, and application of nanomaterials are also enumerated, and their future prospects are outlined for the reader’s benefit.

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“…C-dots can be synthesized using either top-down or bottom-up approaches [ 43 ]. Top-down techniques turn larger materials into nanoparticles by reducing them.…”

Section: Carbon Dots (C-dots)mentioning

confidence: 99%

Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies

Sharma

Choi

Lee

2023

Oxidative Medicine and Cellular Longevity

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In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory properties of C-dots against inflammation-associated diseases have not been systematically reviewed. Hence, this review discusses the anti-inflammatory effects of C-dots in in vivo and in vitro models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. The compiled studies demonstrate the promising potential of C-dots as anti-inflammatory agents for the development of new drugs.

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Carbon dot-based biosensors for the detection of communicable and non -communicable diseases

Cited by 29 publications

References 222 publications

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Optically Active Nanomaterials and Its Biosensing Applications—A Review

Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies

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