2018
DOI: 10.1002/adhm.201800042
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Carbon‐Dot‐Decorated TiO2 Nanotubes toward Photodynamic Therapy Based on Water‐Splitting Mechanism

Abstract: The use of visible light to produce reactive oxygen species (ROS) from renewable water splitting is a highly promising means in photodynamic therapy (PDT). Up to date, diverse inorganic-organic hybrid materials developed as photosensitizers still undergo low therapeutic efficiency and/or poor stability. Herein, a kind of carbon-nanodot-decorated TiO nanotubes (CDots/TiO NTs) composite is developed and applied for photodynamic therapy. Upon 650 nm laser light excitation, the emissions with short wavelengths (32… Show more

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Cited by 58 publications
(36 citation statements)
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“…Interestingly, tumors often over‐express hydrogen peroxide (H 2 O 2 , usually at a generation rate of 5 nmol per 10 5 cells h −1 ), and H 2 O 2 could be a source for O 2 production within tumors . Thus, various kinds of nanoparticle‐based catalysts/enzymes have been constructed to catalyze the decomposition of H 2 O 2 to generate O 2 for ameliorating tumor hypoxia, including MnO 2 , CaO 2 , carbon nitride, carbon dots, biological catalase, and others . These reported nanoplatforms have shown outstanding catalytic activity for in situ endogenous O 2 generation, consequently leading to high therapeutic effect on account of the production of highly cytotoxic 1 O 2 under near‐infrared (NIR) light irradiation .…”
Section: Methodsmentioning
confidence: 99%
“…Interestingly, tumors often over‐express hydrogen peroxide (H 2 O 2 , usually at a generation rate of 5 nmol per 10 5 cells h −1 ), and H 2 O 2 could be a source for O 2 production within tumors . Thus, various kinds of nanoparticle‐based catalysts/enzymes have been constructed to catalyze the decomposition of H 2 O 2 to generate O 2 for ameliorating tumor hypoxia, including MnO 2 , CaO 2 , carbon nitride, carbon dots, biological catalase, and others . These reported nanoplatforms have shown outstanding catalytic activity for in situ endogenous O 2 generation, consequently leading to high therapeutic effect on account of the production of highly cytotoxic 1 O 2 under near‐infrared (NIR) light irradiation .…”
Section: Methodsmentioning
confidence: 99%
“…The produced electrons can reduce the absorbed molecular oxygen to superoxide radicals, and the holes are capable of oxidizing the water molecules into hydrogel radicals (•OH). Therefore, TiO 2 nanoparticles can function as the inorganic photosensitizers to produce large amounts of reactive oxygen species (ROS) for photodynamic therapy (PDT) . Especially, the semiconductor nature and unique photoresponsiveness of TiO 2 have been employed for the degradation of organic substrates and deactivation of microorganisms/viruses …”
Section: Introductionmentioning
confidence: 99%
“…These results demonstrate that TiO 2 sol plays a vital role in enhancing the antibacterial activity. TiO 2 has been reported to be a suitable material for antimicrobial activities and this effect of TiO 2 originates from the generation of reactive oxygen species (ROS) formed with light irradiation [23]. Photocatalytic antibacterial efficiency of TiO 2 is still not high due to the rapid recombination of the electron and hole.…”
Section: Antibacterial Studiesmentioning
confidence: 99%