Carbon Dots From An Immunomodulatory Plant for Cancer Cell Imaging, Free Radical Scavenging and Metal Sensing Applications

Mohapatra, Debadatta; Alam, Bayazeed; Pandey, Vivek; Pratap, Ravi; Dubey, Pawan K.; Parmar, Avanish Singh; Naik, Gaurav Gopal

doi:10.2217/nnm-2021-0190

Cited by 14 publications

(2 citation statements)

References 43 publications

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“…Fresh DPPH methyl alcohol solution (100 μM) was produced in the dark. Varying quantities of Chl‐CQD were diluted with DI water and volume was produced up to 1 ml to prepare primary working solutions of different concentrations [35] . Then, 1 mL of each of the preceding primary working solutions was added to 2 mL of produced DPPH solution to obtain Chl‐CQDs samples ranging in concentration from 0 to 100 μg/ml in a total amount of 3 ml.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Chlorophyll Functionalized Carbon Quantum Dots against Cervical Cancer

et al. 2022

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Cervical cancer is an emerging gynecological disorder that affects the morbidity and mortality of the females worldwide. In 2018, according to the World Health Organization, 570,000 women were diagnosed with cervical cancer and 311,000 women died from the condition. Various anticancer agents are in the run to combat cervical cancer but overall results are still demoralizing. Various reports suggest that Quantum dots are being used as promising agents against several types of cancer.In the current study, we synthesized high-quantum yield chlorophyll functionalized carbon quantum dots (Chl-CQDs) from banana leaves with a simple and environment friendly hydrothermal process. The free radical activity of Chl-CQDs was measured using diphenyl picrylhydrazyl (DPPH) and azino-bis (ethylbenzothiazoline sulphonic acid) diammonium salt (ABTS * + ), as well as their cytotoxic, bioimaging, and apoptogenic properties were also evaluated on normal cell line HEK-293 and human cancer cell lines SiHa. Our results of dimethylthiazol diphenyltetrazolium bromide tetrazolium reduction (MTT) assay showed that Chl-CQDs have profound effect on SiHa cells with an IC 50 of approximately 100 μg/ml after 24 hours and no effect HEK-293 cells. Bioimaging and apoptogenic assays confirmed that Chl-CQDs exhibited strong therapeutic potential against SiHa cells and no cytotoxic potential against HEK-293 cells. The cumulative findings suggested that Chl-CQDs exhibited non-cytotoxic nature against HEK-293 cells whereas cytotoxic nature against SiHa cells.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Chlorophyll Functionalized Carbon Quantum Dots against Cervical Cancer

et al. 2022

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“…7b). The zeta potential moderately stable, and values greater than ± 30 mV represent high colloidal stability [91]. The value of zeta potential was found to be 0.894 mV in pH 1.2 (Fig.…”

Section: In-vitro Dissolution and Release Kineticsmentioning

confidence: 91%

Quality by design-based development and optimization of fourth-generation ternary solid dispersion of standardized Piper Longum extract for melanoma therapy

Mohapatra

Kumar

Shreya

et al. 2023

Preprint

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The study aimed to enhance the solubility, dissolution, and oral bioavailability of standardized Piper longum fruits ethanolic extract (PLFEE) via fourth-generation ternary solid dispersion (SD) for melanoma therapy. With the use of solvent evaporation method, the standardized PLFEE was formulated into SD, optimized using Box-Wilson's Central Composite Design (CCD), and evaluated for pharmaceutical performance and in-vivo anticancer activity against melanoma (B16F10) bearing C57BL/6 mice. The optimized SD showed good accelerated stability, high yield, drug content, and content uniformity for bioactive marker piperine (PIP). The X-ray diffraction (XRD), Differential scanning calorimetry (DSC), Polarized Light Microscopy (PLM), and selected area electron diffraction (SAED) analysis revealed its amorphous nature. The Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and High-Performance Thin Layer Chromatography (HPTLC) revealed the compatibility of excipients with the PLFEE. The contact angle measurement and in-vitro dissolution study revealed good wetting of SD and improved dissolution profile as compared to the plain PLFEE. The in-vivo oral bioavailability of SD reflected a significant (p<0.05) improvement in bioavailability (Frel = 188.765%) as compared to plain extract. The in-vivo tumor regression study revealed the improved therapeutic activity of SD as compared to plain PLFEE. Further, the SD also improved the anticancer activity of Dacarbazine (DTIC) as an adjuvant therapy. The overall result revealed the potential of developed SD for melanoma therapy either alone or as an adjuvant therapy with DTIC.

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In Vitro Cancer Cell Imaging, Free Radical Scavenging, and Fe3+ Sensing Activity of Green Synthesized Carbon Dots from Leaves of Piper longum

et al. 2022

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Carbon Dots From An Immunomodulatory Plant for Cancer Cell Imaging, Free Radical Scavenging and Metal Sensing Applications

Cited by 14 publications

References 43 publications

Therapeutic Potential of Chlorophyll Functionalized Carbon Quantum Dots against Cervical Cancer

Therapeutic Potential of Chlorophyll Functionalized Carbon Quantum Dots against Cervical Cancer

Quality by design-based development and optimization of fourth-generation ternary solid dispersion of standardized Piper Longum extract for melanoma therapy

In Vitro Cancer Cell Imaging, Free Radical Scavenging, and Fe3+ Sensing Activity of Green Synthesized Carbon Dots from Leaves of Piper longum

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