Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

Liang, Ke; Zhao, Fanghao; Nan, Fangfang; Wang, Jian; Zhang, Yunxiu; Li, Jian; Xue, Xiaokuang; Chen, Tiejin; Kong, Lin; Ge, Jiechao; Wang, Pengfei

doi:10.1039/d3qm00008g

Cited by 7 publications

(1 citation statement)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results revealed the potential of Co‐HCS/D/A as a promising nanodrug for cancer treatment (Figure 4g). [ 33 ] In addition, the body weights of mice in all experimental groups increased and showed no obvious variation during 22 days of treatment, which could be attributed to the good biocompatibility of Co‐HCS/D/A (Figure 4f). [ 34 ] The H&E staining of major organ slices from the experimental groups exhibited no apparent alterations in physiological morphology compared to the control group (Figure S19, Supporting Information), further demonstrating the low biotoxicity of Co‐HCS/D/A.…”

Section: Resultsmentioning

confidence: 98%

A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption

Liang,

Nan,

Wang

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

Nanozyme‐based metabolic regulation triggered by tumor‐specific endogenous stimuli has emerged as a promising therapeutic strategy for tumors. The current efficacy, however, is constrained by the limited concentration of endogenous substrates and the metabolic plasticity of tumors. Consequently, the implementation of efficient metabolic regulation in tumor therapy is urgently needed. Herein, a versatile nanozyme‐based nicotinamide adenine dinucleotide (NADH) circulating oxidation nanoreactor is reported. First, the synthesized cobalt‐doped hollow carbon spheres (Co‐HCS) possess NADH oxidase (NOX)‐mimicking activity for the NADH oxidation to disrupt oxidative phosphorylation (OXPHOS) pathway of tumor cells. Second, the substrate‐cycle manner of Co‐HCS can be used for NADH circulating oxidation to overcome the limitation of substrate deficiency. Finally, 2‐Deoxy‐D‐glucose (2‐DG) and 6‐aminonicotinamide (6‐AN) are introduced to block glycolysis and pentose phosphate pathway (PPP), thus creating a versatile nanozyme‐based NADH circulating oxidation nanoreactor (Co‐HCS/D/A) for tumor therapy through triple cellular metabolism disruption. In vitro and in vivo results demonstrate that the designed nanoreactor not only enhances the catalytic efficiency but also disrupts the tumor metabolic homeostasis, leading to efficient therapy outcome. This study develops a novel NADH circulating oxidation nanoreactor for tumor therapy through triple cellular metabolism disruption, which addresses the limitations of current nanozyme‐based metabolism regulation for tumor therapy.

show abstract

Section: Resultsmentioning

confidence: 98%

A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption

Liang,

Nan,

Wang

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

show abstract

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Dong,

Wang,

Chen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving the ROS‐induced toxicity therapy mediated by ROS producers and antioxidant therapy by ROS scavengers. Nanotechnology advancements have led to the development of numerous nanomaterials with ROS‐modulating capabilities, among which carbon dots (CDs) standing out as noteworthy ROS‐modulating nanomedicines own their distinctive physicochemical properties, high stability, and excellent biocompatibility. Despite progress in treating ROS‐related diseases based on CDs, critical issues such as rational design principles for their regulation remain underexplored. The primary cause of these issues may stem from the intricate amalgamation of core structure, defects, and surface states, inherent to CDs, which poses challenges in establishing a consistent generalization. This review succinctly summarizes the recently progress of ROS‐modulated approaches using CDs in disease treatment. Specifically, it investigates established therapeutic strategies based on CDs‐regulated ROS, emphasizing the interplay between intrinsic structure and ROS generation or scavenging ability. The conclusion raises several unresolved key scientific issues and prominent technological bottlenecks, and explores future perspectives for the comprehensive development of CDs‐based ROS‐modulating therapy.

show abstract

Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase

Hao,

Zhang,

Zhang

et al. 2024

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

Abstract: The therapeutic efficacy of reactive oxygen species (ROS)-mediated cancer treatments is significantly limited by shortage of substrates, such as hypoxia in photodynamic therapy (PDT). The development of effective nanoplatform based...

Cited by 7 publications

References 83 publications

A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption

A Versatile Nanozyme‐Based NADH Circulating Oxidation Reactor for Tumor Therapy through Triple Cellular Metabolism Disruption

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase

Contact Info

Product

Resources

About