Carbon dots; the smallest photoresponsive structure of carbon in advanced drug targeting

Ridha, Abbas Amer; Pakravan, Parvaneh; Azandaryani, Abbas Hemati; Zhaleh, Hossein

doi:10.1016/j.jddst.2019.101408

Cited by 36 publications

(16 citation statements)

References 139 publications

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“…The chemical ablation method produces dots with poor control over size. 55,70,71 In 2012 Fang et al 70 used acetic acid, water, and phosphorus pentoxide (P 2 O 5 ) and required no external heat source to synthesize fluorescent CDs. Water and P 2 O 3 exothermically reacted to produce heat and polyphosphoric acid (PPA).…”

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confidence: 99%

“…This method is highly tunable in terms of size, composition, and crystallinity, but suffers from complexity and difficulty in purifying the produced dots. 64,65,55 An example of the template method was outlined by Liu et al using silica spheres as carriers for the aqueous synthesis of CDs. 72 The satellite-like polymer/F127/ silica composite templates were prepared by an aqueous route using silica colloid spheres functionalized with amphiphilic triblock copolymer F127 (EO 106 PO 70 EO 106, M w = 12 600; EO = ethylene oxide, PO = propylene oxide) as carriers and resols (phenol/formaldehyde resins, M w < 500) as carbon precursors.…”

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confidence: 99%

“…The disadvantage is that this method is complex. 67,55,67 Kwon et al used the reverse micelle method to produce graphene CDs. 67 The method used sugar as the carbon source and was highly tunable in terms of size and controlled by the water surfactant molar ratios.…”

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confidence: 99%

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Biomass-Based Carbon Dots: Current Development and Future Perspectives

2021

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Carbon dots have been considered as a solution to the challenges that semiconductor quantum dots have encountered because they are more biocompatible and can be synthesized from abundant and nontoxic materials such as biomass. This review will highlight the advantages of these biomass-based carbon dots in terms of synthesis, properties, and applications in the biomedical field. Furthermore, future applications especially in the biomedical field of biomass-based carbon dots as well as the challenges of semiconductor quantum dots such as biocompatibility, photobleaching, environmental challenges, toxicity, and poor solubility will be discussed in detail. Biomass-derived quantum dots, a subsection of carbon dots that are the most desirable for future research, will be focused upon including from synthesis to applications. Finally, the future development of biomass derived quantum dots in the biomedical field will be discussed and evaluated to unlock the potential for their applications.

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Biomass-Based Carbon Dots: Current Development and Future Perspectives

2021

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“…126 Carbon quantum dots (CQDs) are produced generally by bottom up methods. [127][128][129][130][131] There are characterized by the following properties: quasi-spherical shape with lateral dimension smaller than 10 nm, amorphous structure-dominantly composed of sp 3 hybridized carbon, good chemical stability, tunable photoluminescence and optical band gap, resistance to photo-bleaching and low cytotoxicity under ambient light conditions. [132][133][134][135][136][137][138][139][140][141][142][143][144] Graphene quantum dots (GQDs) are photoactive nanomaterials produced by top down method from graphite or carbon nanotubes.…”

Section: O N L I N E F I R S Tmentioning

confidence: 99%

Self-assembly of carbon based nanoparticles films by Langmuir-Blodgett method

Stanković

Todorovic-Markovic

Marković

2020

JSCS

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It must be stressed that the manuscript still has to be subjected to copyediting, typesetting, English grammar and syntax corrections, professional editing and authors' review of the galley proof before it is published in its final form. Please note that during these publishing processes, many errors may emerge which could affect the final content of the manuscript and all legal disclaimers applied according to the policies of the Journal.

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“…The use of nanosciences in nanomedicine and more specifically in the field of pharmaceutical science for innovation of drug nanocarriers in the management of disease as well as a cancer therapy is set to spread rapidly. [1][2][3][4][5] In this field, targeted drug delivery have been explored for nominal cancer therapy by exploration of several carriers and methods. [6][7][8] Solid lipid nanoparticles (SLNs) as cost-effective and significant drug carriers has been fabricated for liposomes replacement two decades ago.…”

Section: Introductionmentioning

confidence: 99%

Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

et al. 2020

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Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient's health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles (SLNs) were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. DSC proved the conjugation of amino acid to the surface of carriers. The in vitro epirubicin (EPI) release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated SLNs of EPI on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier has a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug.

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Carbon dots; the smallest photoresponsive structure of carbon in advanced drug targeting

Cited by 36 publications

References 139 publications

Biomass-Based Carbon Dots: Current Development and Future Perspectives

Biomass-Based Carbon Dots: Current Development and Future Perspectives

Self-assembly of carbon based nanoparticles films by Langmuir-Blodgett method

Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

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