Carbon fibers for treatment of cancer metastasis in bone

Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Katsumi; Okamoto, Masato; Sobajima, Atsushi; Yoshida, Kazuhide; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsumi; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto

doi:10.1039/d0ra05992g

Cited by 5 publications

(3 citation statements)

References 38 publications

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Section: Progressively Advanced Clinical Applications Of Nanocarbon B...mentioning

confidence: 99%

“…To explain such an application, the use of CNFs supplemented with an anticancer agent for cancer-metastasized bone was examined, as described below. [53] When cancer has metastasized to the bone, the patient's quality of life decreases largely due to pain and functional impairment from bone destruction. [54][55][56][57][58][59][60][61][62][63][64][65] Traditionally, DDSs for cancer treatment have been prepared with biodegradable materials; however, the cancer-metastasized bone environment varies widely and lacks order, and the timing of sustained drug release and other factors cannot be controlled satisfactorily with the use of conventional materials.…”

Section: Administration Of Nanocarbon Particles Locally In Life-threa...mentioning

confidence: 99%

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Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

et al. 2022

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Over the past 15 years, numerous studies have been conducted on the use of nanocarbons as biomaterials towards such applications as drug delivery systems, cancer therapy, and regenerative medicine. However, the clinical use of nanocarbons remains elusive, primarily due to short‐ and long‐term safety concerns. It is essential that the biosafety of each therapeutic modality be demonstrated in logical and well‐conducted experiments. Accordingly, the fundamental techniques for assessing nanocarbon biomaterial safety have become more advanced. Optimal controls are being established, nanocarbon dispersal techniques are being refined, the array of biokinetic evaluation methods has increased, and carcinogenicity examinations under strict conditions have been developed. The medical implementation of nanocarbons as a biomaterial is in sight. With a particular focus on carbon nanotubes, these perspectives aim to summarize the contributions to date on nanocarbon applications and biosafety, introduce the recent achievements in evaluation techniques, and clarify the future prospects and systematic introduction of carbon nanomaterials for clinical use through practical yet sophisticated assessment methods.

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Section: Progressively Advanced Clinical Applications Of Nanocarbon B...mentioning

confidence: 99%

Section: Administration Of Nanocarbon Particles Locally In Life-threa...mentioning

confidence: 99%

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

et al. 2022

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“…TNs have unique physiochemical properties that can be customized to integrate into the bone ECM at the nanoscale. Particularly, carbon nanotubes (CNTs), 8,9 titanium oxide nanotubes (TNTs), 10,11 halloysite nanotubes (HNTs), 12,13 silica nanotubes (SiNTs), 14,15 and hydroxyapatite nanotubes (HANTs) 16,17 have been studied as bone regenerative biomaterials, as they can provide high aspect ratio ECM-like scaffold morphologies.…”

Section: Introductionmentioning

confidence: 99%