Carbon monoxide poisoning

Raub, James A.; Mathieu-Nolf, M.; Hampson, Neil B.; Thom, Stephen R.

doi:10.1016/s0300-483x(99)00217-6

Cited by 629 publications

(462 citation statements)

References 69 publications

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“…[1] Exposure to the colorless, tasteless, and odorless gas is difficult to discern as the initial symptoms of poisoning (headache, dizziness, and confusion) are nonspecific. In the United States, the Occupational Safety and Health Administration (OSHA) has designated permissible exposure limits of 50 ppm over eight hours and 200 ppm over five minutes.…”

Section: Introductionmentioning

confidence: 99%

Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity

Savagatrup

Schroeder

et al. 2017

Angewandte Chemie

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Correspondence to: Timothy M. Swager. + These authors contributed equally to this work.Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.org/ 10.1002/anie.201707491. Conflict of interestThe authors declare the following competing financial interest(s): A patent has been filed on this technology. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptCarbon monoxide (CO) outcompetes oxygen when binding to the iron center of hemeproteins, leading to a reduction in blood oxygen level and acute poisoning. Harvesting the strong specific interaction between CO and the iron porphyrin provides a highly selective and customizable sensor. We report the development of chemiresistive sensors with voltage-activated sensitivity for the detection of CO comprising iron porphyrin and functionalized single-walled carbon nanotubes (F-SWCNTs). Modulation of the gate voltage offers a predicted extra dimension for sensing. Specifically, the sensors show significant increase in sensitivity toward CO when negative gate voltage is applied. The dosimetric sensors are selective to ppm levels of CO and functional in air. UV/Vis spectroscopy, differential pulse voltammetry, and density functional theory reveal that the in situ reduction of Fe III to Fe II enhances the interaction between the F-SWCNTs and CO. Our results illustrate a new mode of sensors wherein redox active recognition units are voltageactivated to give enhanced and highly specific responses. CommunicationsRevving up for sensing: A platform for voltage-activated, chemiresistive gas detection has been delveloped based on covalently functionalized single-walled carbon nanotubes decorated with voltage-responsive chemical selectors. The sensor is highly selective towards CO in the presence of oxygen, nitrogen, and carbon dioxide and is robust to humidity and remains operational in air. KeywordsCarbon monoxide; carbon nanotubes; iron porphyrin; sensors; voltage-activated Carbon monoxide (CO) is responsible for more than half of all fatal poisoning worldwide. [1] Exposure to the colorless, tasteless, and odorless gas is difficult to discern as the initial symptoms of poisoning (headache, dizziness, and confusion) are nonspecific. In the United States, the Occupational Safety and Health Administration (OSHA) has designated permissible exposure limits of 50 ppm over eight hours and 200 ppm over five minutes. [2] The affinity of iron porphyrin towards CO is well-documented for the enzymes cytochrome P450, [3][4][5] hemoglobin, [6] and myoglobin. [7] This high affinity for CO over O 2 of hemoglobin and myoglobin is the underlying mechanism of carbon monoxide poisoning in mammals. [8,9] Although detectors for CO are available, there remains a need for massively [16,17] Theoretical and experimental reports have suggested that CO does not engage in charge transfer with pristine SWCNTs, [18][19][20] indicating the a chemical reactive interface is necessary. Conductivity...

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Section: Introductionmentioning

confidence: 99%

Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity

Savagatrup

Schroeder

et al. 2017

Angewandte Chemie

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“…Patients who survive the initial poisoning can develop delayed neurologic dysfunction, which occurs in 14-40% of serious cases. At present CO is one of the commonly encountered poison in our environment and a leading cause of poisoning world wide [1][2][3]. Poisoning can be acute, subacute and chronic [4].…”

Section: Introductionmentioning

confidence: 99%

Mehta¹,

Das²,

Sn³

2007

Medical Journal Armed Forces India

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“…At moderate concentration, impaired vision and reduced brain function may occur. In pregnancy it results in low birth weight and prenatal death (USEPA, 1997, Raub et al, 2000WHO, 2004). Health effects of carbon monoxide are not only determined by its pollution level, but the time spent breathing polluted air.…”

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confidence: 99%

“…Health effects of carbon monoxide are not only determined by its pollution level, but the time spent breathing polluted air. There is paucity of information on indoor levels of carbon monoxide in Nigeria and in many developing countries (Raub et al, 2000). Therefore the aim of this paper is to provide a baseline data of carbon monoxide level in Kano city of Nigeria.…”

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confidence: 99%

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Carbon Monoxide as Indoor Pollutant in Kano Metropolis

Ayodele¹,

Adekiya²,

Yakubu³

2010

Journal of Applied Sciences and Environmental Management

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ABSTRACT:The level of carbon monoxide concentrations in three different residential areas of Kano municipality has been determined. Health effects of carbon monoxide are not only determined by its pollution level, but the time spent breathing polluted air. Samples of carbon monoxide gas in three different residential districts within the Kano Metropolis; the high (city), medium (Sabon gari) and low (Nassarawa) density residential districts were assessed. The frequency distribution pattern for the gas is skewed towards high frequency of low concentration with a mean and standard deviation of 4.93 ± 3.08µg/m 3 . Evidence linking high level of indoor carbon monoxide to low birth weight and increase in prenatal deaths necessitates the need to periodically check the levels of the gas within each house hold in the metropolis. @JASEM

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Carbon monoxide poisoning — a public health perspective

Cited by 629 publications

References 69 publications

Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity

Bio‐Inspired Carbon Monoxide Sensors with Voltage‐Activated Sensitivity

Carbon Monoxide Poisoning

Carbon Monoxide as Indoor Pollutant in Kano Metropolis

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