Carbon Nanomaterials for Photothermal Therapies

Yu, Jiantao; Yang, Lingyan; Yan, Junyan; Wang, Wencheng; Chen, Yi‐Chun; Chen, Hung-Hsiang; Lin, Chia‐Hua

doi:10.1002/9781119373476.ch12

Cited by 8 publications

(9 citation statements)

References 156 publications

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“…It was reported that well‐dispersed CNTs alleviate in vivo solid tumors at very low NIR intensities. Moreover, the Raman scattering test has demonstrated that injected CNTs exhibit ultra‐high controllability for tumors [110] . Moon and other researchers developed a mouse model that showed remarkable in vivo biocompatibility of PEG‐functionalized single‐wall carbon nanotubes [111] .…”

Section: Emerging Applications Of Nanocarbonsmentioning

confidence: 99%

“…Moreover, the Raman scattering test has demonstrated that injected CNTs exhibit ultra-high controllability for tumors. [110] Moon and other researchers developed a mouse model that showed remarkable in vivo biocompatibility of PEG-functionalized single-wall carbon nanotubes. [111] These researches have proved the safety of carbon nanotubes in photothermal therapy.…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

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Nanostructured Carbons: Towards Soft‐Bioelectronics, Biosensing and Theraputic Applications

Marzana

Morsada

Faruk

et al. 2022

The Chemical Record

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Recently, nanostructured carbon‐based soft bioelectronics and biosensors have received tremendous attention due to their outstanding physical and chemical properties. The ultrahigh specific surface area, high flexibility, lightweight, high electrical conductivity, and biocompatibility of 1D and 2D nanocarbons, such as carbon nanotubes (CNT) and graphene, are advantageous for bioelectronics applications. These materials improve human life by delivering therapeutic advancements in gene, tumor, chemo, photothermal, immune, radio, and precision therapies. They are also utilized in biosensing platforms, including optical and electrochemical biosensors to detect cholesterol, glucose, pathogenic bacteria (e. g., coronavirus), and avian leucosis virus. This review summarizes the most recent advancements in bioelectronics and biosensors by exploiting the outstanding characteristics of nanocarbon materials. The synthesis and biocompatibility of nanocarbon materials are briefly discussed. In the following sections, applications of graphene and CNTs for different therapies and biosensing are elaborated. Finally, the key challenges and future perspectives of nanocarbon materials for biomedical applications are highlighted.

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Section: Emerging Applications Of Nanocarbonsmentioning

confidence: 99%

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Nanostructured Carbons: Towards Soft‐Bioelectronics, Biosensing and Theraputic Applications

Marzana

Morsada

Faruk

et al. 2022

The Chemical Record

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“…A wide range of carbon-based nanomaterials have been described for PTT because they present relatively high absorbance in the biological window, good biocompatibility, easy-to-modify surfaces, and good dispersibility in biological fluids ( 82 ). Robinson et al reported the use of single-layered non-covalently PEGylated reduced graphene oxide (rGO) nanosheets for GBM PTT ( 36 ).…”

Section: In Vitro Cellular Studies Concerning Nanoparticles-mentioning

confidence: 99%

Photothermal Therapy for the Treatment of Glioblastoma: Potential and Preclinical Challenges

2021

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Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. However, its development is hampered by the distinctive features of this tumor. Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. Subsequently, a near infrared light irradiating the head must cross multiple barriers to reach the tumor site without causing any local damage. Its power intensity needs to be within the safety limit and its penetration depth should be sufficient to induce deep and localized hyperthermia and achieve tumor destruction. To properly monitor the therapy, imaging techniques that can accurately measure the increase in temperature within the brain must be used. In this review, we report and discuss recent advances in nanoparticle-mediated plasmonic photothermal therapy for GBM treatment and discuss the preclinical challenges commonly faced by researchers to develop and test such systems.

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“…Studies have shown that different carbon nanomaterials could act as excellent NIR light-absorbing and PTT agents , such as graphene, carbon nanotubes, carbon onions, and so on. Very recently, a novel class of graphene oxide has been reported as a photothermal therapeutic agent for the ablation of lung cancer cells.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the total conversion of incident light to heat is a more complete parameter to evaluate materials efficiency. 22,23 Studies have shown that different carbon nanomaterials could act as excellent NIR light-absorbing and PTT agents 24,25 such as graphene, 26 carbon nanotubes, 27 carbon onions, 28 reported as a photothermal therapeutic agent for the ablation of lung cancer cells. Graphene nanosheets were fabricated using Memecylon edule.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Near-Infrared Photothermal Efficiency of Biocompatible Flame-Synthesized Carbon Nano-Onions with Metal Dopants and Silica Coating

Fragal

Silva

et al. 2020

ACS Appl. Bio Mater.

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As an alternative to eliminating cancer cells with minimal impacts on the nearby tissues, biocompatible nanoparticles based on silica-coated carbon nano-onions, with outstanding photothermal efficiency, are presented. Metal-doped carbon nano-onion@SiO2 materials are produced using flame synthesis. Metal complexes are injected in the flame to tune the carbon organization levels, which results in materials with excellent photostability and total photothermal conversion efficiency, regarding the incident light input, as higher as 48% for 785 nm laser. It was found that the metal dopant, even at a very low content, plays an interesting role in photothermal efficiency. We tested the effect of thin silica layers on the carbon nanosphere, first as a way to improve biocompatibility and provide a more reactive surface toward the modifications process to add vectorizing agents. Despite the primary goal of the silica shell, a notable increase in photothermal efficiency was observed. In vivo studies of the biological response to the materials as probed by the zebrafish model found that the as-prepared carbon nanospheres and the SiO2-coated particles are highly biocompatible. The SiO2-coated samples were found to be more suitable for photothermal application, due to the higher colloidal stability and higher photothermal efficiency.

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Carbon Nanomaterials for Photothermal Therapies

Cited by 8 publications

References 156 publications

Nanostructured Carbons: Towards Soft‐Bioelectronics, Biosensing and Theraputic Applications

Nanostructured Carbons: Towards Soft‐Bioelectronics, Biosensing and Theraputic Applications

Photothermal Therapy for the Treatment of Glioblastoma: Potential and Preclinical Challenges

Enhancing Near-Infrared Photothermal Efficiency of Biocompatible Flame-Synthesized Carbon Nano-Onions with Metal Dopants and Silica Coating

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