Carbon nanotube for targeted drug delivery

Raval, Jignesh P.; Joshi, Parth; Chejara, Dharmesh R.

doi:10.1016/b978-0-12-813741-3.00009-1

Cited by 26 publications

(14 citation statements)

References 33 publications

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“…They are often used in many nanotechnological applications. But the main obstacle is the high manufacturing cost (Raval et al, 2018). Thus more research is needed to develop an affordable synthesis technique.…”

Section: Single-walled Nanotubesmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

137

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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Section: Single-walled Nanotubesmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

137

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“…Some properties of nanocarriers and nanoparticles which are crucial for their penetration across the BBB are summarized in Table 2. CNT 1 (diameter), >1000 (length) MWNTs-NH 3 + penetrates the brain and accumulates depending on crystalline order [116,140] Viral vectors are widely used for gene modification and delivery (Figure 7). This method can provide long-term expression of the transgene in non-dividing cells, especially with adeno-associated viral (AAV) vectors [141].…”

Section: Nanocarriers Nanoparticles and Vectorsmentioning

confidence: 99%

Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

2019

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Treatment of certain central nervous system disorders, including different types of cerebral malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs due to possible serious side effects and/or lack of the brain penetration and, therefore, the efficacy of the drugs is diminished. During the last decade, several new technologies were developed to overcome barrier properties of cerebral capillaries. This review gives a short overview of the structural elements and anatomical features of the blood–brain barrier. The various in vitro (static and dynamic), in vivo (microdialysis), and in situ (brain perfusion) blood–brain barrier models are also presented. The drug formulations and administration options to deliver molecules effectively to the central nervous system (CNS) are presented. Nanocarriers, nanoparticles (lipid, polymeric, magnetic, gold, and carbon based nanoparticles, dendrimers, etc.), viral and peptid vectors and shuttles, sonoporation and microbubbles are briefly shown. The modulation of receptors and efflux transporters in the cell membrane can also be an effective approach to enhance brain exposure to therapeutic compounds. Intranasal administration is a noninvasive delivery route to bypass the blood–brain barrier, while direct brain administration is an invasive mode to target the brain region with therapeutic drug concentrations locally. Nowadays, both technological and mechanistic tools are available to assist in overcoming the blood–brain barrier. With these techniques more effective and even safer drugs can be developed for the treatment of devastating brain disorders.

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“…They are made from graphene sheets rolled into a seamless cylinder ( Figure 1 ) that can be open ended or capped, having a high aspect ratio with diameters as small as 1 nm, and length of several micrometers [ 44 ]. In recent years, CNTs have emerged as excellent NDDPs owing to their excellent cell penetration aptitude, anisotropic conductivity/semi-conductivity, thermal properties, ultrahigh surface area (maximizes the ability of CNTs to talk with biological matter), hollow interior (provides an enormous cargo-carrying capacity for drug-loading) and their readily functionalized exteriors which permit the tailoring of solubility/biological recognition [ 45 , 46 ]. Based on layers of CNTs, they are generally divided into two categories ( Figure 1 ): single-walled carbon nanotubes (SWCNTs; consist of single layer of cylinder graphene) and multi-walled carbon nanotubes (MWCNTs; contain multiple layers of graphene sheets) [ 46 , 47 ].…”

Section: Inorganic Nddps Implicated In Anti-cancer Therapymentioning

confidence: 99%

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Naz

Shamoon

Wang

et al. 2019

IJMS

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Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

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Carbon nanotube for targeted drug delivery

Cited by 26 publications

References 33 publications

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

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