Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for tissue engineering applications

Luo, Yu; Wang, Shige; Shen, Mingwu; Qi, Ruiling; Fang, Yi; Guo, Rui; Cai, Hong; Cao, Xueyan; Tomás, Helena; Zhu, Meifang; Shi, Xiangyang

doi:10.1016/j.carbpol.2012.08.069

Cited by 98 publications

(48 citation statements)

References 50 publications

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“…These porous structures include sponges, fiber matrices, hydrogels, and nanofiber matrices with varied pore properties and mechanical strength. These scaffolds were applied for a variety of soft tissue and hard tissue regeneration based on their mechanical properties . Pore properties and mechanical strength of scaffolds play a significant role in bone tissue engineering.…”

Section: Cellulosementioning

confidence: 89%

Polysaccharide biomaterials for drug delivery and regenerative engineering

Shelke

James

Laurencin

et al. 2014

Polymers for Advanced Techs

255

148

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Polymers derived from plant (polysaccharides) and animal (proteins) kingdoms have been widely used for a variety of biomedical applications including drug delivery and tissue regeneration. These polymers due to their biochemical similarity with human extracellular matrix components are readily recognized and accepted by the body. Natural polymers inherit numerous advantages including natural abundance, relative ease of isolation, and room for chemical modification to meet varying technological needs. In addition, these polymers undergo enzymatic and/or hydrolytic degradation in biologic environments into non-toxic degradation byproducts. Polysaccharides (carbohydrates) are often isolated and purified from renewable sources including plants, animals, and microorganisms. Majority of these polymers are found in the extracellular matrix components of organisms and participate in inter and intracellular cell signaling and contribute to their growth. All these features offer polysaccharide-based biomaterials much desired biological recognition, biocompatibility, and bioactivity. In spite of many merits as biomaterials, these polysaccharides suffer from drawbacks including variations in material properties based on source, microbial contamination, uncontrolled water uptake, poor mechanical strength, and unpredictable degradation patterns. These inconsistencies have limited the usage of polysaccharides and biomedical application related technology development. Many of these polysaccharides have been chemically modified to achieve consistent physicochemical properties including mechanical stability, degradation, and bioactivity and processed into microparticles, hydrogels, and 3D porous structures for tissue regeneration applications. Presence of multiple functionalities on the polymer backbone allows easy structure modifications for the required application. The current article focuses on the application of polysaccharide-based materials in regenerative engineering and delivery.

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Section: Cellulosementioning

confidence: 89%

Polysaccharide biomaterials for drug delivery and regenerative engineering

Shelke

James

Laurencin

et al. 2014

Polymers for Advanced Techs

255

148

View full text Add to dashboard Cite

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“…17 However, many of these polymers may not provide a cost effective substrate with appropriate degradation and mechanical properties required for wound healing scaffolds. In particular, it has been shown that cellulose acetate nanofibers do not have appropriate mechanical properties for tissue engineering applications, 18 and PLGA does not exhibit long term in vivo degradation required for the treatment of chronic wounds. 19 Therefore, the purpose of this study was to investigate the feasibility of using only biodegradable poly(L-lactic acid) (PLA) as a nanofibrous carrier for ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

et al. 2015

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This article presents successful incorporation of ibuprofen in polylactic acid (PLA) nanofibers to create scaffolds for the treatment of both acute and chronic wounds. Nanofibrous PLA scaffolds containing 10, 20, or 30 wt % ibuprofen were created and ibuprofen release profiles quantified. In vitro cytotoxicity to human epidermal keratinocytes (HEK) and human dermal fibroblasts (HDF) of the three scaffolds with varying ibuprofen concentrations were evaluated and compared to pure PLA nanofibrous scaffolds. Thereafter, scaffolds loaded with ibuprofen at the concentration that promoted human skin cell viability and proliferation (20 wt %) were evaluated in vivo in nude mice using a full thickness skin incision model to determine the ability of these scaffolds to promote skin regeneration and/or assist with scarless healing. Both acellular and HEK and HDF cell-seeded 20 wt % ibuprofen loaded nanofibrous bandages reduced wound contraction compared with wounds treated with Tegaderm™ and sterile gauze. Newly regenerated skin on wounds treated with cell-seeded 20 wt % ibuprofen bandages exhibited significantly greater blood vessel formation relative to acellular ibuprofen bandages. We have found that degradable anti-inflammatory scaffolds containing 20 wt % ibuprofen promote human skin cell viability and proliferation in vitro, reduce wound contraction in vivo, and when seeded with skin cells, also enhance new blood vessel formation. The approaches and results reported here hold promise for multiple skin tissue engineering and wound healing applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 327-339, 2017.

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“…[217] However, studies such as those by Zhu et al have inferred a significant degree of genotoxicity (DNA interference) in the use of MWCNTs as scaffolds, [218] symptomatic of a wider challenge presented by the use of nanomaterials. In addition, several metal NPs, including titanium oxide, zinc oxide, magnesium oxide, silver, iron oxide (Feo, Fe 2 O 3 , Fe 3 O 4 ), copper, copper oxide, aluminium oxide, (alumina, Al 2 O 3 ) and silicon oxide, highly interact with the cellular environment and cause serious health risks to neurons and brain function.…”

Section: Neurotoxicity Of Nanomaterials (Nanoneurotoxicity)mentioning

confidence: 99%

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Kumar

Tan

Wong

et al. 2017

Adv Funct Materials

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Unlocking the secrets of the brain is a task fraught with complexity and challenge – not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network-operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided.

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Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for tissue engineering applications

Cited by 98 publications

References 50 publications

Polysaccharide biomaterials for drug delivery and regenerative engineering

Polysaccharide biomaterials for drug delivery and regenerative engineering

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

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