Carbon nanotube/polysulfone screen-printed electrochemical immunosensor

Sánchez, Samuel; Pumera, Martin; Fàbregas, Esteve

doi:10.1016/j.bios.2007.04.021

Cited by 116 publications

(42 citation statements)

References 30 publications

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“…Several disposable electrochemical immunosensors using different electroactive materials such as conducting polymers, 43 graphite, 44 carbon nanotubes, 45 or metals 46 47 Delivered by Publishing 50 and Viswanathan et al 51 for the detection of the carcinoembryonic antigen, a tumor marker. In the former, the authors have proposed a sensitive electrochemical immunosensor based on a carbon nanoparticle-modified screen-printed graphite electrode covered with specific antibodies, using CdS nanocrystals as biotracers as a strategy for signal amplification.…”

Section: Disposable Immusensorsmentioning

confidence: 99%

Disposable Biosensors for Clinical Diagnosis

Janegitz¹,

Cancino²,

Zucolotto³

2014

j. nanosci. nanotech.

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We present an overview on the use of disposable electrochemical biosensors for diagnostics, focusing on the applications of these devices as immunosensors and DNA sensors in the point-of-care diagnostics. Analytical biosensors have emerged as efficient alternatives for the detection of innumerous diseases, because of their high specificity and the convenience of detecting the electrochemical signals produced by the presence of an analyte using a portable equipment. This review highlights the recently developed strategies toward immobilization of different biological molecules on disposable electrodes such as carbon nanotubes and metal nanoparticles. In the course of the review, we first introduced the disposable biosensors, followed by an overview of the immunosensors, and discussed the applications of DNA sensors and disposable biosensors in point-of-care diagnostics. We also have evaluated the prospects and future applications of these devices in the field of biomedical research.

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Section: Disposable Immusensorsmentioning

confidence: 99%

Disposable Biosensors for Clinical Diagnosis

Janegitz¹,

Cancino²,

Zucolotto³

2014

j. nanosci. nanotech.

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“…10 Advances in biomolecular detection have included use of nanomaterials, such as nanotubes, nanoparticles, and nanowires, as a medium of signal amplification. [11][12][13] In recent years, due to its interesting properties, including a large surface area, superior conductivity, biocompatibility, and high stability, nanoporous gold has attracted considerable attention. Several methods, including electrochemical deposition, 14 electrochemical erosion, 15 "direct freezing", 16 a voltage-induced dimension change method, 17 a "dealloying process", template synthesis, 21,22 and repetitive square-wave oxidationreduction cycle (SWORC) 23 were been used to prepare a three-dimensional gold (3D-Au) nanostructure.…”

Section: Introductionmentioning

confidence: 99%

Sensitive electrochemical immunosensor based on three-dimensional nanostructure gold electrode

Zhong¹,

Lan²,

Zhang³

et al. 2015

IJN

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A sensitive electrochemical immunosensor was developed for detection of alpha-fetoprotein (AFP) based on a three-dimensional nanostructure gold electrode using a facile, rapid, “green” square-wave oxidation-reduction cycle technique. The resulting three-dimensional gold nanocomposites were characterized by scanning electron microscopy and cyclic voltammetry. A “sandwich-type” detection strategy using an electrochemical immunosensor was employed. Under optimal conditions, a good linear relationship between the current response signal and the AFP concentrations was observed in the range of 10–50 ng/mL with a detection limit of 3 pg/mL. This new immunosensor showed a fast amperometric response and high sensitivity and selectivity. It was successfully used to determine AFP in a human serum sample with a relative standard deviation of <5% (n=5). The proposed immunosensor represents a significant step toward practical application in clinical diagnosis and monitoring of prognosis.

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“…1, 5 The effects of adsorption on the bioactive state of proteins are also of critical importance in many other applications, such as the development and optimization of surfaces for biosensors, 6,7 bioactive nanoparticles, [8][9][10][11][12] biocatalysis, [13][14][15][16] bioanalytical systems for diagnostics and detection, [17][18][19][20][21][22] and bioseparations. 13,15,23 Because of its importance, protein adsorption behavior has been intensively studied over the past several decades.…”

Section: Introductionmentioning

confidence: 99%

Molecular simulation of protein-surface interactions: Benefits, problems, solutions, and future directions (Review)

2008

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While the importance of protein adsorption to materials surfaces is widely recognized, little is understood at this time regarding how to design surfaces to control protein adsorption behavior. All-atom empirical force field molecular simulation methods have enormous potential to address this problem by providing an approach to directly investigate the adsorption behavior of peptides and proteins at the atomic level. As with any type of technology, however, these methods must be appropriately developed and applied if they are to provide realistic and useful results. Three issues that are particularly important for the accurate simulation of protein adsorption behavior are the selection of a valid force field to represent the atomic-level interactions involved, the accurate representation of solvation effects, and system sampling. In this article, each of these areas is addressed and future directions for continued development are presented.

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Carbon nanotube/polysulfone screen-printed electrochemical immunosensor

Cited by 116 publications

References 30 publications

Disposable Biosensors for Clinical Diagnosis

Disposable Biosensors for Clinical Diagnosis

Sensitive electrochemical immunosensor based on three-dimensional nanostructure gold electrode

Molecular simulation of protein-surface interactions: Benefits, problems, solutions, and future directions (Review)

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