Carbon Nanotube Strain Sensor Based Hemoretractometer for Blood Coagulation Testing

Li, Zida; Wang, Yi–Ze; Xue, Xufeng; McCracken, Brendan; Ward, Kevin R.; Fu, Jianping

doi:10.1021/acssensors.7b00971

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…, resistance and capacitance) or optical − characteristics. Nanomaterials such as carbon nanotubes, − metallic nanowires, − nanoparticles (NPs), − and two-dimensional materials ( e.g. , graphene) , were generally used as sensing materials.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Durable Sea-Urchin-Shaped Silver Nanoparticles Strain Sensors for Human-Activity Monitoring

Zou

Ouyang

et al. 2021

ACS Appl. Mater. Interfaces

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High-performance strain sensors, composed of various artificial sensing materials on/in stretchable substrates, show great promise for applications in flexible electronic devices. Here, we demonstrated a highly sensitive and durable strain sensor consisting of a ribbon of close-packed sea-urchin-shaped silver nanoparticles (SUSNs) sandwiched between two layers of poly(dimethylsiloxane) (PDMS). Each of SUSNs possesses highdensity and spherically distributed sharp spines over the body, which promotes electron transduction and further improves signal detection. This SUSN-based sensor possesses a desirable integration of high sensitivity (a gauge factor of 60) and large stretchability (up to 25%) at tensile sensing, broadening its application in wearable devices. Moreover, it also shows fast response (48 ms), good reproducibility, and long-term stability (>2500 cycles at 20% strain). It can also be used to detect compressing (sensitivity up to 31.5) and folding-type bending deformations. The sensing mechanism, the resistance of the sensors varying as the deformation load, results from the inter-spine contacts change and the microcracks evolution caused by variation in the gap between SUSNs. The sensor's sensitivity at different degrees of strain was also achieved by controlling the width of the closepacked SUSNs ribbon. For practical demonstration, the SUSN-based sensors could be used as wearable devices for monitoring human activities ranging from subtle deformations to substantial movements.

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Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Durable Sea-Urchin-Shaped Silver Nanoparticles Strain Sensors for Human-Activity Monitoring

Zou

Ouyang

et al. 2021

ACS Appl. Mater. Interfaces

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“…In this regard, researchers have explored different polymer matrixes and conductive nanofillers. The literature encompasses various polymer matrixes such as poly(vinylidene difluoride) (PVDF), − poly(methyl methacrylate) (PMMA), , polydimethylsiloxane (PDMS), − epoxy, polyvinyl alcohol (PVA), polyaniline (PANI), and polyethylene terephthalate (PET) to cite a few. Among the various polymers, PVDF is an inherent piezo material with good mechanical strength and hydrophobic in nature .…”

Section: Introductionmentioning

confidence: 99%

Waterproof Flexible Polymer-Functionalized Graphene-Based Piezoresistive Strain Sensor for Structural Health Monitoring and Wearable Devices

et al. 2020

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In recent times, flexible piezoresistive polymer nanocomposite-based strain sensors are in high demand in wearable devices and various new age applications. In the polymer nanocomposite-based strain sensor, the dispersion of conductive nanofiller remains challenging due to the competing requirements of homogenized dispersion of nanofillers in the polymer matrix and retaining of the inherent characteristics of nanofillers. In the present work, waterproof and flexible poly(vinylidene difluoride) (PVDF) with a polymer-functionalized hydrogenexfoliated graphene (HEG)-based piezoresistive strain sensor is developed and demonstrated. The novelty of the work is the incorporation of polystyrene sulfonate sodium salt (PSS) polymer-functionalized HEG in a PVDF-based flexible piezoresistive strain sensor. The PSS-HEG provides stable dispersion in the hydrophobic PVDF polymer matrix without sacrificing its inherent characteristics. The electrical conductivity of the PVDF/PSS-HEG-based strain sensor is 0.3 S cm −1 , which is two orders of magnitude higher than the PVDF/HEG-based strain sensor. Besides, near the percolation region, the PVDF/PSS-HEG shows a maximum gauge factor of 10, which is about two times higher than the PVDF/HEG-based flexible strain sensor and 5-fold higher than the commercially available metallic strain gauge. The enhancement in the gauge factor is due to the stable dispersion of PSS-HEG in the PVDF matrix and electron conjugation caused by the adherence of negatively charged sulfonate functional groups on the HEG. The developed waterproof flexible strain sensor is demonstrated using portable wireless interfacing device for various applications. This work shows that the waterproof flexible PVDF/ PSS-HEG-based strain sensor can be a potential alternative to the commercially available metallic strain gauge.

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“…Another type of the electrical measurement based on carbon nanotube strain sensors has been reported as well. These strain sensors are embedded within the micropillars which can sense mechanical force due to clotting blood droplet and the resulting force is transferred to the resistive nanotube strain sensor (Li et al, 2018).…”

Section: Poc Tests Based On Electrical and Electrochemical Measurementsmentioning

confidence: 99%

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Aria

Erten

Yalçın

2019

Front. Bioeng. Biotechnol.

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In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-effective point of care (POC) devices. These devices measure electrochemical, optical, and mechanical parameters of clotting blood. Which can be correlated to light transmission/scattering, electrical impedance, and viscoelastic properties. In this regard, this paper discusses the working principles of blood coagulation monitoring, physical and sensing parameters in different technologies. In addition, we discussed the recent progress in developing nanomaterials for blood coagulation detection and treatments which opens up new area of controlling and monitoring of coagulation at the same time in the future. Moreover, commercial products, future trends/challenges in blood coagulation monitoring including novel anticoagulant therapies, multiplexed sensing platforms, and the application of artificial intelligence in diagnosis and monitoring have been included.

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Carbon Nanotube Strain Sensor Based Hemoretractometer for Blood Coagulation Testing

Cited by 8 publications

References 28 publications

Highly Sensitive and Durable Sea-Urchin-Shaped Silver Nanoparticles Strain Sensors for Human-Activity Monitoring

Highly Sensitive and Durable Sea-Urchin-Shaped Silver Nanoparticles Strain Sensors for Human-Activity Monitoring

Waterproof Flexible Polymer-Functionalized Graphene-Based Piezoresistive Strain Sensor for Structural Health Monitoring and Wearable Devices

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

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