Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction

Weng, Xuexiang; Wang, Meiyan; Ge, Jing; Yu, Shaoning; Liu, Baohong; Zhong, Jun; Kong, Jilie

doi:10.1039/b906948h

Cited by 52 publications

(30 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Weng et al 103 proposed recombined ricin A chain (RTA)-induced selective destruction of tumor cells through CNT transporters. The conjugate of MWCNTs and toxin protein RTA was translocated into the cytoplasm of various cell lines, which induced cell death.…”

Section: Cnts As Carriers Of Proteins and Immunoactive Componentsmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

228

106

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

show abstract

Section: Cnts As Carriers Of Proteins and Immunoactive Componentsmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

228

106

View full text Add to dashboard Cite

show abstract

“…Kam and coworkers [12] have used a conjugate of streptavidin with SWNTs-biotin, which resulted in internalization of the protein into model cancer cells by adsorption-mediated endocytosis. Transmission electron and confocal microscopy have shown that MWNTs can act as transporters of the recombinant ricin A chain protein, resulting in high death rates of cancer cells (e.g., up to 75% of HeLa cells were killed) [46].…”

Section: Cnts As Carriers Of Immunoactive Compounds Proteinsmentioning

confidence: 99%

Carbon Nanotubes in Cancer Therapy and Drug Delivery

Elhissi

Ahmed

Dhanak

et al. 2012

Emerging Nanotechnologies in Dentistry

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. CNTs can be functionalized (i.e., surface engineered) with certain functional groups in order to manipulate their physical or biological properties. In addition to the ability of CNTs to act as carriers for a wide range of therapeutic molecules, their large surface area and possibility to manipulate their surfaces and physical dimensions have been exploited for use in the photothermal destruction of cancer cells. This paper paper will discuss the therapeutic applications of CNTs with a major focus on their applications for the treatment of cancer.

show abstract

“…The nanometer size and unique physical properties of CNTs make them attractive for anticancer drug delivery [4][5][6][7][8], molecular transport [9][10][11], and new therapeutic mechanisms [12,13]. CNTs have been activated to target various cancer cells using folic acid (FA).…”

Section: Introductionmentioning

confidence: 99%

Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered NMR spectroscopy

Castillo

Torres

Molina

et al. 2012

Carbon

View full text Add to dashboard Cite

Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered nmr spectroscopy, Carbon (2012), doi: 10.1016/j.carbon. 2012.02.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered nmr spectroscopy ABSTRACTA conjugate between single-walled carbon nanotubes, chitosan and folic acid has been prepared. It was characterized by diffusion ordered two-dimensional hydrogen-1 nuclear magnetic resonance and hydrogen-1 nuclear magnetic resonance spectroscopy which revealed the presence of a conjugate that was generated by the linkage between the carboxyl moiety of the folic acid and the amino group of the chitosan, which in turn was non-covalently bound to the single-walled carbon nanotubes. The obtained diffusion coefficient values demonstrated that free folic acid diffused more rapidly than the folic acid conjugated to single-walled carbon nanotubes-chitosan. The values of the proton signal of hydrogen-1 nuclear magnetic resonance spectroscopy and two-dimensional hydrogen-1 nuclear magnetic resonance spectroscopy further confirmed that the folic acid was conjugated to the chitosan, wrapping the single-walled carbon nanotubes.

show abstract

Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction

Cited by 52 publications

References 22 publications

Carbon nanotubes as cancer therapeutic carriers and mediators

Carbon nanotubes as cancer therapeutic carriers and mediators

Carbon Nanotubes in Cancer Therapy and Drug Delivery

Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered NMR spectroscopy

Contact Info

Product

Resources

About