Carbon nanotubes in cancer diagnosis and therapy

Ji, Shun rong; Liu, Chen; Zhang, Bo; Yang, Feng; Xu, Jin; Jiang, Long; Jin, Chen; Fu, De Liang; Ni, Quan Xing; Lei, Yu

doi:10.1016/j.bbcan.2010.02.004

Cited by 220 publications

(140 citation statements)

References 81 publications

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“…their small size, large surface area, high reactivity, and high aspect ratio, are also the main factors of potential cytotoxicity. It is thought that, although there may be several mechanisms of causing cell damage, the main way would be due to DNA damage (Ji et al, 2010). The study suggests that SWCNTs can induce adverse cellular responses through activation of molecular signaling associated with oxidative stresses (cancer inducing).…”

Section: Toxicity Of Carbon Nanotubesmentioning

confidence: 98%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

116

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Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

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Section: Toxicity Of Carbon Nanotubesmentioning

confidence: 98%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

116

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“…İn vitro çalışmalarda KNT'lere maruz bırakılan hücrelerin farklı derecelerde toksisite gös-terdiği tespit edilmiştir (90)(91)(92)(93)(94)(95)(96). Bununla beraber bu toksisitenin sadece konsantrasyona bağlı olmadığı; bunun yanı sıra KNT'lerin fiziksel şekli, aglomerasyon durumu ya da fonksiyonalizasyon derecesine bağlı olabildiği de rapor edilmiştir (90)(91)(92)(93)(94). KNT'lerin fare ve sıçanlara uygulandığı birkaç çalışmada, akciğer, karaciğer ya da dalak gibi majör organlarda KNT birikiminden kaynaklanan olumsuz etkiler görülmüş-tür.…”

Section: İlaç Taşinmasinda Nanotaşiyicilarin Dezavantajlariunclassified

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Coşan¹,

Ak²,

Dag³

et al. 2016

Tuberk Toraks

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“…A particularly interesting is their use in the field of biomedicine: in biosensors [6,7], medical diagnostics [8,9], transplantology [10,11], tissue engineering [12] or in pharmacology -including the field of targeted therapies [13][14][15][16].…”

Section: Methods Of Dispersing Carbon Nanotubes -The Search For Optimmentioning

confidence: 99%

Congo Red Interactions with Single-Walled Carbon Nanotubes

Jagusiak

Piekarska

Chłopaś

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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A new method of dispersion of single-wall carbon nanotubes (SWNT) in aqueous solution using supramolecular compounds is proposed in this chapter. The described system consists of SWNT overlaid by Congo red. SWNT are formed from a rolled layer of graphene, providing a large surface area for binding compounds with planar, aromatic structures (including drugs). Congo red is able to associate with proteins in the form of supramolecular, ribbon-like structures, and may bind various drugs by intercalation.The study reveals strong interactions between Congo red and the surface of SWNT. The authors' aim was to explain the mechanism driving this interaction. Spectral analysis of the SWNT-CR complex, effects of sonication on CR binding, microscopic imaging and molecular modelling analyses are all discussed. Results indicate that binding of supramolecular Congo red to the surface of nanotubes is based on face-to-face stacking. Having attached itself to the surface of a nanotube, a dye molecule may attract other similarly oriented molecules, giving rise to a protruding supramolecular appendage. This explains the high affinity of CR for nanotubes and the resulting system's capability to bind drugs.Analysis of complexes formed by SWNT-CR with the model drug (DOX) and with other planar compounds (EB, TY) indicates that it may be possible to construct complexes capable of binding multiple compounds simultaneously.

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Carbon nanotubes in cancer diagnosis and therapy

Cited by 220 publications

References 81 publications

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Congo Red Interactions with Single-Walled Carbon Nanotubes

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