Carbon Nanotubes Reinforced Hydroxyapatite Composite for Biomedical Application

Parwez, Khalid; Budihal, Suman V.

doi:10.1166/jbns.2014.1194

Cited by 7 publications

(5 citation statements)

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“…Higher stress may be attributed to the reinforcement of the polymer matrix and the exhibition of higher strain is complemented with the increase in ductility in the nanocomposites ( Table 1 ) with high MWCNT content. This strain behavior is ascribed to the longitudinal orientation and the thread-like formation of the MWCNT, observed in the TEM pictures in Figure 3 (b), which facilitates the effective transfer of stress from the matrix to the MWCNT [ 13 , 15 , 30 ]. High ductility coupled with higher stress ( Table 1 ) has resulted in a higher strain.…”

Section: Resultsmentioning

confidence: 99%

“…Carbon nanotubes or single layers of graphene rolled into a cylinder shape, have been commonly applied and evolved into diverse research directions including medical applications. CNT usually exists in 2 phases, single-walled and multiwalled, with different characteristics properties [28][29][30][31][32][33]. There are different types of techniques that have been improved for synthesizing CNT which mainly involve vapor phase routes.…”

Section: Introductionmentioning

confidence: 99%

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Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

et al. 2020

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Fracture in the hip joint is a major and quite common health issue, particularly for the elderly. The loads exploited by the lower limbs are very acute and severe; in the femur, they can be several folds higher than the whole weight of the body. Nanotechnology and nanocomposites offer great potential in biomedical applications. The organic materials are more biocompatible. Mechanical properties like strength and hardness are challenging parameters which control the selection of a joint. HDPE in its pure form has been successfully used as a prosthetic foot (external) but failed as an implant material due to limited mechanical properties. High-density polyethylene thermoplastic polymer (HDPE) and multi-walled carbon nanotubes (MWCNT)/Nano-Alumina is selected as a potential material for a biomedical implant and its mechanical properties and biocompatibility have been discussed. HDPE/MWCNT/Alumina (Al 2 O 3) nanocomposites have not been explored yet for prosthetic implants. These nanocomposites were prepared in this investigation in different compositions. Prepared material has been physiochemically characterized to check the morphology and the structure. MWCNTs enhanced hardness and elastic modulus of the HDPE. Optimization of the material composition revealed that hybrid composite with structure (2.4% Al 2 O 3 and 0.6% MWCNT) exhibits better mechanical properties compared to other ratios with 3% MWCNTs and 5% MWCNTs. Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding MWCNT to HDPE. The moisture absorption decreased to 90% with 5% MWCNT. Experimental results of Colorimetric assay (MTT) of a normal human epithelial cell line (1-BJ1) over Al 2 O 3 /MWCNT@HDPE showed <20% cytotoxic activity, proving its acceptance for medical use. HDPE/MWCNT/Al 2 O 3 nanocomposites emerged as a candidate material for artificial joints.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

et al. 2020

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“…Although HAp offers several advantageous features for bone TE, it has several limitations such as slow degradation, low fracture toughness, and high brittleness. These properties have restricted the use of solid HAp in scaffold design, especially for load-bearing bone defects. , To overcome these limitations, HAp ceramic-based and HAp polymer-based composite scaffolds have been investigated. − Carbon nanotubes and silica have been used to produce HAp ceramic composite scaffolds. − Natural polymers, such as gelatin, starch, collagen, bacterial cellulose, alginate, and chitosan, as well as the synthetic polymers polycaprolactone (PCL), polylactic acid (PLA), and poly(vinyl alcohol) (PVA), have been used to fabricate HAp polymer composite scaffolds. ,, …”

Section: Eggshellmentioning

confidence: 99%

Avian Egg: A Multifaceted Biomaterial for Tissue Engineering

Mahdavi

Amirsadeghi

Jafari

et al. 2021

Ind. Eng. Chem. Res.

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Avian eggs offer a natural and environmentally friendly source of raw materials, and many of their components hold great potential in tissue engineering. An avian egg consists of several beneficial elements: the protective eggshell, the eggshell membrane, the egg white (albumen), and the egg yolk (vitellus). The eggshell is mostly composed of calcium carbonate and has intrinsic biological properties that stimulate bone repair. It is a suitable precursor for the synthesis of hydroxyapatite and calcium phosphate, which are particularly relevant to bone tissue engineering. The eggshell membrane is a thin protein-based layer with a fibrous structure composed of several valuable biopolymers, such as collagen and hyaluronic acid, also found in the human extracellular matrix. As a result, the eggshell membrane has found several applications in skin tissue repair and regeneration. The egg white is a protein-rich material that is under investigation for the design of functional protein-based hydrogel scaffolds. The egg yolk, composed mainly of lipids, also contains diverse essential nutrients (e.g., proteins, minerals, and vitamins) and has potential applications in wound healing and bone tissue engineering. This review summarizes the advantages and status of egg components in tissue engineering and regenerative medicine as well as their current limitations and future perspectives.

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“…Carbon nanotubes or single layers of graphene rolled into a cylinder shape, have been commonly applied and evolved into diverse research directions: mechanics, and even medical applications. CNT usually exists in 2 phases, single-walled and multiwalled, with different characteristics properties [6][7][8][9][10][11]. There are different types of techniques that have been improved for synthesizing CNT which mainly involve vapor phase routes.…”

Section: Introductionmentioning

confidence: 99%

Experimental Design of AL2O3/MWCNT/HDPE Hybrid Nanocomposites for Hip Joint Replacement

Dabees

Kamel

Tirth

et al. 2020

Preprint

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Abstract A hip fracture can be considered a major health issue facing the elderly fraction of humans. The loads exploited by the lower limbs are very acute and severe; in the femur, they can be several folds higher than the whole weight of the body. Mechanical properties like strength and hardness are challenging parameters which control the selection of the joint. In this research work, a modification has been performed by adding multi-layer carbon nanotubes to the High-density polyethylene thermoplastic polymer together with alumina. Prepared material well physiochemically characterized to check the morphology and the structure. Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding Multi-wall carbon nanotubes (MWCNT)to the polymer. According to mechanical properties results, MWCNTs successfully increase in young’s module and hardness of the polymer. Optimization of the materials ration has been done and it has been found that hybrid composite with structure (2.4% AL 2 O 3 and 0.6% MWCNT) obtains high mechanical properties compared to other ratios with 3% MWCNTs and 5% MWCNTs. Also, moisture absorption decreased to 90% at with 5% MWCNT ratio. Experimental results of MTT assay of a normal human epithelial cell line (1- BJ1) over AL 2 O 3 /MWCNT@ HDPE showed a low value of cytotoxic activity, which proves that it is proper for medical use.AL 2 O 3 /MWCNT@HDPE composite showed promising results for further studies of artificial joints.

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Carbon Nanotubes Reinforced Hydroxyapatite Composite for Biomedical Application

Cited by 7 publications

References 0 publications

Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

Avian Egg: A Multifaceted Biomaterial for Tissue Engineering

Experimental Design of AL2O3/MWCNT/HDPE Hybrid Nanocomposites for Hip Joint Replacement

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Carbon Nanotubes Reinforced Hydroxyapatite Composite for Biomedical Application

Cited by 7 publications

References 0 publications

Experimental design of Al 2 O 3 /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

Experimental design of Al 2 O 3 /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

Avian Egg: A Multifaceted Biomaterial for Tissue Engineering

Experimental Design of AL2O3/MWCNT/HDPE Hybrid Nanocomposites for Hip Joint Replacement

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Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement

Experimental design of Al ₂ O ₃ /MWCNT/HDPE hybrid nanocomposites for hip joint replacement