Carbon Quantum Dots Based Chemosensor Array for Monitoring Multiple Metal Ions

Abstract

The simultaneous identification of multiple metal ions in water has attracted enormous research interest in the past few decades. We herein describe a novel method for multiple metal ion detection using a carbon quantum dots (CQDs)-based chemosensor array and the CQDs are functionalized with different amino acids (glutamine, histidine, arginine, lysine and proline), which act as sensing elements in the sensor array. Eleven metal ions are successfully identified by the designed chemosensor array, with 100% classification accuracy. Importantly, the proposed method allowed the quantitative prediction of the concentration of individual metal ions in the mixture with the aid of a support vector machine (SVM). The sensor array also enables the qualitative detection of unknown metal ions under the interference of tap water and local river water. Thus, the strategy provides a novel high-throughput approach for the identification of various analytes in complex systems.

Optical chemo sensors based on nanocellulose for selective detection of hazardous pollutants: A review

“…The sensor array also allows for the qualitative detection of unidentified metal ions in presence of ordinary water. As a result, the method offers unique high-throughput approach for identifying different analytes in complex systems [71].…”

New Amino Acid-Based Thiosemicarbazones and Hydrazones: Synthesis and Evaluation as Fluorimetric Chemosensors in Aqueous Mixtures

“…These features allow for higher detection sensitivity and lower detection and quantification limits, and their intrinsic biological nature also allows for prospective use in fluorescence-based biological assays, such as targeting peptides for molecular imaging; enzyme activity; or site-specific protein labelling for the in vivo tracking of protein localization, dynamics and concentration [4][5][6][7][8]. From a survey of the most recent literature, examples of amino acids and peptides involved in solution-or material-based fluorescent sensing were found to be highly varied and included a tryptophan-quinoline conjugate for the turn-off detection of Fe 2+ [9]; dipeptide receptors with aggregation-induced emission properties for the recognition of methylmercury and Hg 2+ [10]; cellulose nanofibers modified with L-histidine for the detection of Cr 6+ and Hg 2+ [11]; gold-silver bimetallic nanoclusters capped with tryptophan for the detection of histamine [12]; a near-infrared fluorophore based on a methionine attached to a chromenylium-cyanine for the analysis of Hg 2+ in the environment and living cells [13]; a phenylalanine-based dual-channel probe for the detection of Fe 3+ ; Cu 2+ and F − [14]; pyrene-phenylalanine conjugates for Cu 2+ analysis [15]; a derivative of tyrosine as a turn-off fluorescent sensor for Hg 2+ [16]; carbon quantum dots functionalized with different amino acids (glutamine, histidine, arginine, lysine and proline), capable of monitoring multiple metal ions in water [17]; and a series of pentapetides bearing tyrosine for the detection of Cu 2+ at the nanomolar level [18]. These are only a few examples that confirm the growing interest in and application of amino acids/peptides as bio-inspired systems for sensing.…”