Carbon quantum dots functionalized tapered optical fiber for highly sensitive and specific detection of Leptospira DNA

Zainuddin, Nurul Hida; Chee, Hui Yee; Rashid, Suraya Abdul; Ahmad, Muhammad Zamharir; Bakar, M. H. Abu; Mahdi, Mohd Adzir; Yaacob, Mohd Hanif

doi:10.1016/j.optlastec.2022.108696

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…[20]. Furthermore, the LOD of our biosensor is much smaller than that of in previous works [19][20][21]37]. The proposed SMF microcavity biosensor has the advantages of simple structure, low cost, and high sensitivity; it has a broad application prospect in the field of biosensors.…”

Section: Results Of Complementary Dna Hybridization Detectionmentioning

confidence: 87%

“…Optical fiber sensors have recently gained more and more attention because of their ability to serve as label-free, real-time, highly sensitive, and rapidly responsive DNA hybridization sensors. Currently, various optical fiber sensors are available for in situ DNA hybridization detection, including optical fiber surface plasmon resonance (SPR) sensors [ 14 , 15 , 16 ], optical fiber gratings [ 11 , 17 , 18 ], and optical fiber interferometers [ 19 , 20 , 21 , 22 ]. Leung A et al reported on gold-coated tapered optical fiber sensors for DNA detection.…”

Section: Introductionmentioning

confidence: 99%

“…However, its reliance on tilted gating and SPR makes the fabrication complex, requiring a special polarization light source to excite the SPR effect. Zainuddin et al proposed a DNA hybridization detection method utilizing a carbon quantum dots-functionalized tapered optical fiber [ 19 ]. This sensor achieved an LOD of 1.0 fM and exhibited substantial affinity and high sensitivity of 1.8295 nm/nM.…”

Section: Introductionmentioning

confidence: 99%

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Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

Wu,

Wang,

et al. 2024

Sensors

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A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.

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Section: Results Of Complementary Dna Hybridization Detectionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

Wu,

Wang,

et al. 2024

Sensors

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“…In 2019, Zhang et al [122] employed a single-layer poly-L-lysine and single-stranded DNA probe for functionalizing double-S tapered optical fibers based on microcore fibers, demonstrating excellent specificity and reproducibility in label-free DNA hybridization detection. In 2023, Zainuddin et al [123] further developed a carbon quantum dot-enhanced sensor for the detection of Helicobacter pylori DNA, as shown in Figure 21. With a detection limit of 1.0 fM, the sensor exhibited a favorable sensitivity of 1.8295 nm/nM and a low dissociation constant.…”

Section: Dna Hybridizationmentioning

confidence: 99%

The Structure and Applications of Fused Tapered Fiber Optic Sensing: A Review

Ban,

Lian

2024

Photonics

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Tapered optical fibers have continuously evolved in areas such as distributed sensing and laser generation in recent years. Their high sensitivity, ease of integration, and real-time monitoring capabilities have positioned them as a focal point in optical fiber sensing. This paper systematically introduces the structures and characteristics of various tapered optical fiber sensors, providing a comprehensive overview of their applications in biosensing, environmental monitoring, and industrial surveillance. Furthermore, it offers insights into the developmental trends of tapered optical fiber sensing, providing valuable references for future related research and suggesting potential directions for the further advancement of optical fiber sensing.

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A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing

Han,

Zhang,

Zhang

et al. 2024

Analytica Chimica Acta

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Carbon quantum dots functionalized tapered optical fiber for highly sensitive and specific detection of Leptospira DNA

Cited by 7 publications

References 30 publications

Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

The Structure and Applications of Fused Tapered Fiber Optic Sensing: A Review

A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing

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