Carbon Tetrachloride-Induced Nephrotoxicity in Mice Is Prevented by Pretreatment with Zinc Sulfate

Yoshioka, Hiroki; Usuda, Haruki; Fukuishi, Nobuyuki; Nonogaki, Tsunemasa; Onosaka, Satomi

doi:10.1248/bpb.b16-00078

Cited by 34 publications

(31 citation statements)

References 30 publications

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“…Total malondialdehyde (MDA) levels were estimated by a colorimetric microplate assay (Oxford Biochemical Research, Oxford, MI, USA) according to the manufacturer's protocol and as previously described (Yoshioka et al, 2016a(Yoshioka et al, , 2016b.…”

Section: Measurement Of Malondialdehyde Levels and Total Antioxidant mentioning

confidence: 99%

Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice

et al. 2017

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-The expression levels or activities of biological defense factors can fluctuate daily following biological rhythms. We have focused on the relationship between injection timing and the degree of toxicity of cadmium (Cd) to promote the concept of "chronotoxicology," which introduces chronobiology to the field of toxicology. Our previous studies have clearly indicated that Cd may be subject to chronotoxicity. In this report, to confirm the character of the Cd-induced chronotoxicity, we performed multidirectional examinations. Male C57BL/6J mice that received a single intraperitoneal injection of CdCl 2 at ZT6 showed drastic hepatic injury estimated by histopathological analyses, i.e., nuclear condensations, fatty degenerations, and hemorrhages, but showed no injury when injected at ZT18. This difference was supported by several biochemical analyses that were indicators of hepatic injury (levels of alanine aminotransferase, aspartate aminotransferase, and malondialdehyde). The chronotoxicity of Cd was also observed in multiple strains (ICR and Balb/c), in a different injection route (subcutaneous), and in multiple injections (5 injections). Based on these results, we propose that chronotoxicology may provide important information not only for toxicology but also for occupational health, i.e., the importance of injection timing for toxicity evaluation tests, the reproducibility of animal experiments, and the improvement in the quality of risk assessments for night shift workers who may be exposed to toxic substances at various times of the day.

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Section: Measurement Of Malondialdehyde Levels and Total Antioxidant mentioning

confidence: 99%

Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice

et al. 2017

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“…15,16) In addition, Anjiki et al reported JTX induced MT in the liver and small intestines. 13) Our current study demonstrate i.p.…”

Section: +mentioning

confidence: 99%

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Yoshioka

Fukaya

Miura

et al. 2016

Biological & Pharmaceutical Bulletin

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“…In addition, not only APAP but also other hepatic injury chemicals such as Cd and bromobenzene reportedly show hepatoprotective effects by pretreatment with Zn or using MT-KO mice [28][29][30]. We also reported that Zn-induced MT expression has a protective effect against CCl 4 -induced hepato-and nephrotoxicity [17,18]. Our current study demonstrates that i.p.…”

Section: Resultsmentioning

confidence: 58%

“…Total malondialdehyde (MDA) levels in the liver were examined with a colorimetric TBARS microplate assay kit (FR40; Oxford Biochemical Research, Oxford, MI, USA) in accordance with the manufacturer's protocol and as previously described [18].…”

Section: Measurement Of Malondialdehyde Levels In Livermentioning

confidence: 99%

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

Yoshioka

Fukaya

Onosaka

et al. 2016

Environ Health Prev Med

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Objective The aim of this study was to investigate whether pretreatment with the Japanese herbal medicine ''Hochuekki-to'' (TJ-41) has an ameliorative effect on carbon tetrachloride (CCl 4 )-induced hepatotoxicity through anorexia prevention. Methods Twenty-four hours before CCl 4 injection, TJ-41 or saline solution was intraperitoneally administered. Furthermore, 24 h after TJ-41 injection, mice were intraperitoneally administered 1.6 g/kg CCl 4 or olive oil. Moreover, 24 h after CCl 4 /olive oil injection, mice from each group were euthanized and bled for plasma analysis. Results Mice injected with CCl 4 exhibited severe anorexia. Moreover, CCl 4 increased the plasma levels of hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase) as well as lipid peroxidation and hepatic Ca levels. Pretreatment with TJ-41 recovered the CCl 4 -induced anorexia and plasma levels of the hepatic injury markers. Moreover, CCl 4 -induced lipid peroxidation and hepatic Ca levels decreased upon TJ-41 pretreatment. In addition, hepatic metallothionein levels in the TJ-41 ? CCl 4 -treated group were decreased by [50 % compared with the levels in the TJ-41-treated group, implying that metallothionein was consumed by CCl 4 -induced radicals. ConclusionOur results suggest that TJ-41 attenuates CCl 4 -induced hepatotoxicity, presumably by the induction of metallothionein, which in turn scavenges radicals induced by CCl 4 exposure.

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Carbon Tetrachloride-Induced Nephrotoxicity in Mice Is Prevented by Pretreatment with Zinc Sulfate

Cited by 34 publications

References 30 publications

Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice

Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice

Suppressive Effect of Kampo Formula “Juzen-taiho-to” on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

Kampo formula “Hochu-ekki-to” suppressed carbon tetrachloride-induced hepatotoxicity in mice

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